Category: 80-32-0

Wang, Fan;Chen, Yangwu;Wang, Lin;Meng, Dan;Zhu, Rongxia;Li, Yong;Tan, Zhouliang;Deng, Qinwen published 《Fates of antibiotic resistance genes during upgrading process of a municipal wastewater treatment plant in southwest China》 in 2022. The article was appeared in 《Chemical Engineering Journal (Amsterdam, Netherlands)》. They have made some progress in their research.Category: pyridine-derivatives The article mentions the following:

This study comprehensively analyzed the fates of antibiotics, antibiotic resistance genes (ARGs) and microbial community during upgrading process of municipal wastewater treatment plant (MWTP) of Anaerobic/Anoxic/Oxic-membrane bioreactor (A2/O-MBR) from regulation to stable operation phase. The factors most affecting ARGs profile were investigated, and the potential hosts for ARGs were further determined Results showed that the removal rate of total antibiotics and the reduction of ARGs increased by 10.49% and 1.37 logs in A2/O-MBR during upgrading process, resp. The most prevalent ARG was sul1 in both water and sludge phase. Mobile genetic elements (MGEs) and microbial community were the most significant factors affecting ARGs distribution in water phase and sludge, resp. Notably, the abundance of potential antibiotic resistance bacteria (ARB) was significantly decreased during upgrading process. Therefore, sul1and intI1 proliferation as well as microbial community succession should be emphasized in ARGs pollution management and control. This study expected to provide a theor. basis for the application of MBR process to remove antibiotics and ARGs in upgrading of MWTPs. To complete the study, the researchers used 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) .

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) is a sulfonamide antibiotic that is usually used as antibacterial anti-inflammatory drug, which has been applied in the treatment of acute urinary tract infections in childhood.Category: pyridine-derivativesDue to its antibiotic activity, this chemical has been selected as an ingredient to prepare antibacterial composition.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Jian, Ningge;Dai, Yuanyuan;Liu, Li-e;Wu, Di;Qi, Feifei;Wu, Yongjun published 《Simultaneous extraction of multi-antibiotic residues in environmental water by DTPA-modified polyaniline nanofibers membrane》 in 2022. The article was appeared in 《Separation and Purification Technology》. They have made some progress in their research.Product Details of 80-32-0 The article mentions the following:

In this study, novel diethylenetriaminepentaacetic acid modified polyaniline nanofibers membrane (DTPA-PANI NFsM) was designed and fabricated. By the synergistic effect of PANI and DTPA, the DTPA-PANI NFsM demonstrated superior sorption performance towards three classes of antibiotics with very different properties: phenicols, tetracyclines and sulfonamides. The mass transfer efficiency of DTPA-PANI NFsM was particularly high. From the isotherm and thermodn. studies, favorable and spontaneous adsorption processes were confirmed. The potential adsorption mechanisms were investigated by FT-IR anal. Under the optimized conditions, an efficient, fast, sensitive and economical method for the high-throughput detection of antibiotic residues in environmental water was developed. Low detection limits (1.6-28.6 ng/L for phenicols, 10-34.3 ng/L for tetracyclines, 0.46-15 ng/L for sulfonamides), broad linear range (1.5 ng/L-5 μg/L) as well as satisfactory recoveries and precisions were obtained. In addition, DTPA-PANI NFsM exhibited excellent regeneration and reusability properties, which could be reused for at least 12 times. Also, the practical application feasibility of the method was confirmed by the test of actual samples.4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) were involved in the experimental procedure.

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) is a sulfonamide antibiotic that is usually used as antibacterial anti-inflammatory drug, which has been applied in the treatment of acute urinary tract infections in childhood.Product Details of 80-32-0Due to its antibiotic activity, this chemical has been selected as an ingredient to prepare antibacterial composition.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Yu;Cheng, Dengmiao;Xie, Jun;Zhang, Yuting;Wan, Yu;Zhang, Yueqiang;Shi, Xiaojun published 《Impacts of farmland application of antibiotic-contaminated manures on the occurrence of antibiotic residues and antibiotic resistance genes in soil: A meta-analysis study》 in 2022. The article was appeared in 《Chemosphere》. They have made some progress in their research.Formula: C10H9ClN4O2S The article mentions the following:

Meta-anal. of 94 published studies was conducted to explore the impacts of farmland application of antibiotic-contaminated manures on antibiotic concentrations and ARG abundances in manure-amended soil. Forty-nine antibiotics were reported, in which chlortetracycline, oxytetracycline, doxycycline, tetracycline, enrofloxacin, ciprofloxacin and norfloxacin were the most prevalent and had relatively high concentrations The responses of ARG and mobile genetic element (MGE) abundances to farmland application of antibiotic-contaminated manures varied considerably under different management strategies and environmental settings. On average, compared to unamended treatments, farmland application of antibiotic-contaminated manures significantly increased the total ARG and MGE abundances by 591% and 351%, resp. (P < 0.05). Of all the included ARG classes, the largest increase was found for sulfonamide resistance genes (1121%), followed by aminoglycoside (852%) and tetracycline (763%) resistance genes. Correlation anal. suggested that soil organic carbon (SOC) was significantly neg. correlated with antibiotic concentrations in manured soil (P < 0.05) due to the formation of covalent bonds and nonextractable residues. Soil silt content was significantly pos. correlated with antibiotic concentration (P < 0.05), which was attributed to greater sorption capacities. The ARG abundances were significantly pos. correlated with soil silt content, antibiotic concentrations, mean annual temperature, SOC, MGEs and soil pH (P < 0.05), suggesting that changes in these factors may shape the ARG profiles. Collectively, these findings advanced our understanding of the occurrence of antibiotics and ARGs in manure-amended soil and potential factors affecting them and will contribute to better management of these contaminants in future agricultural production To complete the study, the researchers used 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) .

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) can be introduced in the drinking water to fabricate aqueous liquid formulations for combating bacterial and protozoal in animals.Formula: C10H9ClN4O2S Besides, sulfachloropyridazine associated to tripelennamine hydrocholoride has been demonstrated to function as an anti-stress agent in poultry after vaccinations.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wu, Huizhen;Zhou, Min;Xu, Jie;Wang, Jianmei;Tong, Jianying;Sun, Nabo;Qian, Mingrong published 《Determining a wide range of antibiotics and pesticides in poultry feathers using selective accelerated solvent extraction-liquid chromatography-mass spectrometry》. The research results were published in《Analytical Methods》 in 2022.Category: pyridine-derivatives The article conveys some information:

This study established a detection method based on accelerated solvent extraction-liquid chromatog.-mass spectrometry for determining residues of 3 chloramphenicols, 8 macrolides, 18 sulfonamides, 4 nitroimidazoles, 15 insecticides, and 22 fungicides in poultry feathers. The extraction solvent, methanol, was used for a static extraction time of 5 min, and repeated three times. Fifty milligrams of adsorbents C18/PSA (1 : 1, W/W) were added to the extraction cell to achieve simultaneous extraction and purification The extraction efficiency of three solvents, methanol, acetonitrile and Et acetate, was investigated. An orthogonal exptl. design was used to explore the optimal combination of extraction temperature, static extraction time, number of extraction cycles, and adsorbent ratio for accelerated solvent extraction After the optimal ratio was determined, the dosage of adsorbents was optimized. The extracted sample solution was concentrated by blowing nitrogen, redissolved, passed through a 0.22 μm PTFE membrane filter, then injected for instrumental anal. The validation results showed that the recovery of the proposed method was 60.4-107.6%, the limit of detection 0.2-3.0 μg kg^-1, and the limit of quantification 0.5-8.3 μg kg^-1. This quant. multi-residue detection method was able to determine the residues of 70 target compounds in poultry feathers.4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) were involved in the experimental procedure.

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) is a sulfonamide antibiotic that is usually used as antibacterial anti-inflammatory drug, which has been applied in the treatment of acute urinary tract infections in childhood.Category: pyridine-derivativesDue to its antibiotic activity, this chemical has been selected as an ingredient to prepare antibacterial composition.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yu, Dan;He, Jiahong;Xie, Taiping;Xu, Qiang;Li, Guoqiang;Du, Ling;Huang, Junhao;Yang, Jun;Li, Wenpo;Wang, Jiankang published 《Peroxymonosulfate activation using a composite of copper and nickel oxide coated on SBA-15 for the removal of sulfonamide antibiotics》. The research results were published in《Environmental Research》 in 2022.Synthetic Route of C10H9ClN4O2S The article conveys some information:

The sluggish Ni(II)/Ni(III) redox cycle does not benefit perxymonosulfate (PMS) activation for recalcitrant pollutant degradation To solve this problem, a heterogeneous catalyst, Cu0.2Ni0.8O/SBA-15 (CNS), was constructed to activate PMS for decomposing two sulfonamide antibiotics, sulfachlorpyridazine (SACP) and sulfapyridine (SAP). SACP and SAP were completely degraded over Cu0.2Ni0.8O/SBA-15/PMS (CNSP) after 90 min. O.-2 was the dominant active species involved in the degradation of SACP and SAP. Structural anal. and elemental valence state observations indicated that Cu(I) provided electrons through Cu-O-Ni bonds to realize the charge compensation for Ni(III) in the CNSP system. Thus, the in situ Cu(I)/Cu(II) promoting the Ni(II)/Ni(III) cycle could accelerate the PMS activation. This work provides new insights into the electron transfer between transition metals and the charge compensation mechanism for PMS activation. The degradation mechanism was proposed based on the XPS results before and after the reaction, a radical quenching test, and an EPR test. Combined with the SACP and SAP degradation intermediates identified by LC-MS, we suggest that the choice of treatment process depends on the occurrence of a steric hindrance effect between the mol. structure of the degradation target and free radicals.4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) were involved in the experimental procedure.

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) can be introduced in the drinking water to fabricate aqueous liquid formulations for combating bacterial and protozoal in animals.Synthetic Route of C10H9ClN4O2S Besides, sulfachloropyridazine associated to tripelennamine hydrocholoride has been demonstrated to function as an anti-stress agent in poultry after vaccinations.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Quality Control of 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamideIn , Liu, Jing;Deng, Wen-Jing;Ying, Guang-Guo;Tsang, Eric P. K.;Hong, Hua-Chang published 《Occurrence and distribution of antibiotics in surface water》. 《Ecotoxicology》published the findings. The article contains the following contents:

The concentrations, distribution, and ecol. risks of 24 typical antibiotics in Hong Kong rivers and seawater were investigated using high-performance liquid chromatog. coupled with electrospray ionization tandem mass spectrometry (UHPLC-EI-MS/MS). The results showed that the select antibiotics were widely distributed in the study area. Among the target antibiotics, the detection rate of tetracyclines (TCs) was 100%, which indicated the widespread use of TCs in Hong Kong. The detection rates of sulfonamides (SAs) (57.1-100%), fluoroquinolones (FQs) (78.6-100%), roxithromycin (RTM) (50%) and novobiocin (NOV) (50%) were all above 50%. Compared with river water (7.9-114.26 ng/L, medium: 27.7 ng/L), concentrations of the most antibiotics in seawater (9.5-32.0 ng/L, medium: 13.3 ng/L) were lower; seawater concentrations were similar to those reported from other coastal cities, such as Guangzhou and Zhuhai in China, which implied that the source of marine antibiotic pollution may be the nearby rivers, and the vastness of the ocean causes environmental dilution of antibiotics. According to the ratio of the measured environmental concentration (MEC) to the predicted no-effect concentration (PNEC), ofloxacin (OFX) (average risk quotient: 1.94E-01) and ciprofloxacin (CFX) (average risk quotient: 3.53E-01) posed medium to high ecol. risk in most places, whereas other antibiotics posed lower risk. In Yuen Long, where there were many livestock farms nearby, the detected concentration of antibiotics was higher, indicating that livestock wastewater may be the major reason for the increase in antibiotic levels in this area. In general, the detected concentration of antibiotics in Hong Kong was lower than that in the United States, Japan, the United Kingdom, and coastal areas of China, but the long-term existence of low concentrations of antibiotics also poses great risks. According to the risk assessment, Hong Kong should pay more attention to the use of FQs (e.g., OFX and CFX) in the future. The experimental procedure involved many compounds, such as 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) .

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) is a sulfonamide antibiotic that is usually used as antibacterial anti-inflammatory drug, which has been applied in the treatment of acute urinary tract infections in childhood.Quality Control of 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamideDue to its antibiotic activity, this chemical has been selected as an ingredient to prepare antibacterial composition.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 80-32-0《A novel calibration strategy based on isotopic distribution for high-throughput quantitative analysis of pesticides and veterinary drugs using LC-HRMS》 was published in 2022. The authors were Sun, Feifei;Tan, Haiguang;Abdallah, Mohamed F.;Li, Yanshen;Zhou, Jinhui;Li, Yi;Yang, Shupeng, and the article was included in《Journal of Hazardous Materials》. The author mentioned the following in the article:

Preparation of calibration curves is a critical step for large-scale quantification. However, this procedure is time-consuming, labor intensive. Herein, a novel isotopologue multipoint calibration (IMC) strategy, was proposed and demonstrated for the simultaneous quantitation of 120 pesticides and 83 veterinary drugs in surface water samples using Liquid Chromatog.-High Resolution Mass Spectrometry (LC-HRMS). In this strategy, the natural isotopic distribution was used to generate external calibration curves, eliminating the need of analyst’s adjustment and many sets of chem. standard solutions required in external calibration curves. Addnl., this strategy was comprehensively validated, and the results indicated this strategy had better performance in both accuracy and precision, fully meeting the requirements for the quant. anal. Interestingly, for the samples with high concentration beyond the upper limit of quantitation, the IMC strategy could avoid samples dilution by monitoring the less abundant isotopic channels. Furthermore, the IMC method was successfully applied in the surface water samples collected from Anhui province, China. Among which, sulfamethoxazole and imidacoprid were the main contributors. In conclusion, we present a promising LC-HRMS strategy for the accurate quantitation of small mols., which has a potential application in food and environmental anal. The experimental procedure involved many compounds, such as 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) .

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) can be introduced in the drinking water to fabricate aqueous liquid formulations for combating bacterial and protozoal in animals.Related Products of 80-32-0 Besides, sulfachloropyridazine associated to tripelennamine hydrocholoride has been demonstrated to function as an anti-stress agent in poultry after vaccinations.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamideIn 2022, Zhu, Xinzhe;He, Mingjing;Sun, Yuqing;Xu, Zibo;Wan, Zhonghao;Hou, Deyi;Alessi, Daniel S.;Tsang, Daniel C. W. published 《Insights into the adsorption of pharmaceuticals and personal care products (PPCPs) on biochar and activated carbon with the aid of machine learning》. 《Journal of Hazardous Materials》published the findings. The article contains the following contents:

The science-informed design of green carbonaceous materials (e.g., biochar and activated carbon) with high removal capacity of recalcitrant organic contaminants (e.g., pharmaceuticals and personal care products (PPCPs)) is indispensable for promoting sustainable wastewater treatment. In this study, machine learning (ML) incorporating PPCPs and biochar properties as well as adsorption conditions were applied to build adsorption prediction models and explore the contributions of various biochars inherent properties to their PPCPs adsorption capacity. The results demonstrated that the models developed by detailed biochar properties (e.g., surface functionality and hierarchical porous structure) from advanced microscopic and spectroscopic techniques were more accurate (i.e., the root-mean-square error decreased by 18-24%) than those by general information such as bulk elemental composition and total pore volume The relative importance of surface carbon functionalities ranked in the order of C-O bond > C=O bond > non-polar carbon for predicting the adsorption capacity. According to the partial dependence anal., the average pore diameters of adsorbents that were larger than the maximum diameter of PPCPs mols. by 1.5-fold to 2.5-fold favored the PPCPs adsorption. This study reveals new insights into the adsorption of PPCPs and provides a comprehensive reference for the sustainable engineering of biochar adsorbents for PPCPs wastewater treatment. The experimental procedure involved many compounds, such as 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) .

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) is a sulfonamide antibiotic that is usually used as antibacterial anti-inflammatory drug, which has been applied in the treatment of acute urinary tract infections in childhood.Reference of 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamideDue to its antibiotic activity, this chemical has been selected as an ingredient to prepare antibacterial composition.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hajrulai-Musliu, Zehra;Uzunov, Risto;Jovanov, Stefan;Jankuloski, Dean;Stojkovski, Velimir;Pendovski, Lazo;Sasanya, James Jacob published 《A new LC-MS/MS method for multiple residues/contaminants in bovine meat》 in 2021. The article was appeared in 《BMC Chemistry》. They have made some progress in their research.Formula: C10H9ClN4O2S The article mentions the following:

A multi-class and multi-residue/contaminant method for the determination of veterinary drug and pesticide residues and mycotoxins in bovine meat has been developed and validated. The veterinary drug residues/contaminants included antimicrobials, anabolic hormones, lactones, β-agonists, mycotoxins, and pesticides. Isotopic labeled internal standards were included to compensate residual matrix effects. The calibrators used in the method demonstrated linearity with the R2 > 0.98. The decision limit (CCα) values were in the range from 0.067 to 2103.84μg/kg, while the range for detection capability (CCβ) was from 0.083 to 2482.13μg/kg. The limit of detection (LOD) and limit of quantification (LOQ) were in the range from 0.059 to 291.36μg/kg, and 0.081 to 328.13μg/kg, resp. The recovery of analytes ranged from 61.28% to 116.20%. The intra-day coefficient of variation (CV) was from 0.97 to 25.93% and the inter-day CV was 2.30-34.04%. The method has been used for the determination of 49 residues/contaminants in bovine meat. Application of the method in routine anal. in bovine samples, revealed in limited samples the presences of enrofloxacin, oxytetracycline and sulfadiazine at the concentration of 35.22μg/kg, 27.35μg/kg, and 36.20μg/kg, resp. And 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) was used in the research process.

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) can be introduced in the drinking water to fabricate aqueous liquid formulations for combating bacterial and protozoal in animals.Formula: C10H9ClN4O2S Besides, sulfachloropyridazine associated to tripelennamine hydrocholoride has been demonstrated to function as an anti-stress agent in poultry after vaccinations.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem