Category: 80194-69-0

Application of 80194-69-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 80194-69-0, name is 5-(Trifluoromethyl)picolinic acid. This compound has unique chemical properties. The synthetic route is as follows.

A mixture of (1S, 4S)-2-{(15)-1-[4-(allyloxy)-2,3-dimethylphenyl]ethyl}-2,5-diazabicyclo-[2.2.1]heptane (7.3 g, 25.5 mmol), 5-(trifluoromethyl)pyridine-2-carboxylic acid (4.97 g, 26.0 mmol), BOP (16.9 g, 38.3 mmol) and NEt3 (8.89 mL, 63.8 mmol) in N,N-dimethylacetamide (50 mL) is heated at 40 C. under N2 overnight. The reaction mixture is cooled to room temperature, diluted with 1N NaOH (100 mL), and extracted with EtOAc. The organic layer is isolated, washed with 1N NaOH, water and brine, dried over Na2SO4, and concentrated under reduced pressure. The residue is purified by silica gel chromatography with EtOAc as the eluent to afford the title compound as a brown oil. 1HNMR (400 MHz, CDCl3) delta: 8.86 (s, 0.67H), 8.83 (s, 0.33H), 8.02-8.13 (m, 2H), 7.28 (m, 1H), 6.72 (m, 1H), 6.07 (m, 1H), 5.43 (m, 1H), 5.26 (m, 1H), 4.97 (s, 1H), 4.49-4.53 (m, 2H), 3.72-4.00 (m, 2H), 3.52 (m, 1H), 3.35 (m, 1H), 3.22 (m, 1H), 2.83 (d, 0.67H), 2.78 (d, 0.33H), 2.33 (s, 2H), 2.25 (s, 1H), 2.21 (s, 2H), 2.19 (s, 1H), 1.95 (m, 1H), 1.72 (m, 1H), 1.25-1.31 (m, 31). LC-MS m/z (M+H): 460.

According to the analysis of related databases, 80194-69-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Hutchinson, Alan J.; Chenard, Bertrand L.; Li, Guiying; Ghosh, Manuka; Tarrant, James G.; Yoon, Taeyoung; Luke, George P.; Lee, Kyungae; O’Donnell, Mary-Margaret E.; Pringle, Wallace C.; Peterson, John M.; Hodgetts, Kevin J.; Steenstra, Cheryl K.; Doller, Dario; US2006/9456; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.80194-69-0, name is 5-(Trifluoromethyl)picolinic acid, molecular formula is C7H4F3NO2, molecular weight is 191.1074, as common compound, the synthetic route is as follows.Product Details of 80194-69-0

A mixture containing CoCl26H2O (12.40 mg, 0.05 mmol), Htpc (9.50 mg, 0.05 mmol),and water (6 mL) was sealed in a 15-mL Teflon-lined stainless steel vessel and heatedat 413 K for 3 days and then cooled to room temperature at a rate of 10 Kh1. Afterfiltration, red block crystals were collected and washed with distilled water severaltimes, then dried at room temperature. Yield: 4.96mg (40%, based on CoCl26H2O).Anal. Calcd (%) for C14H10CoF6N2O6 (molecular weight 475.17 gmol1): C, 35.39; H, 2.12; N, 5.90. Found (%): C, 35.54; H, 2.21; N, 5.98. IR (KBr, cm1): 3347 w, 1663 m,1510 m, 1410 m, 1148w, 936 w, 820 w, 640 w, 473 w.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,80194-69-0, 5-(Trifluoromethyl)picolinic acid, and friends who are interested can also refer to it.

Reference:
Article; Li, Bing; Wang, Jiakai; Song, Huan; Wu, Huanping; Chen, Xiaoyan; Ma, Xiaoxia; Journal of Coordination Chemistry; vol. 72; 15; (2019); p. 2562 – 2573;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 80194-69-0, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 80194-69-0 as follows.

2-Phenoxyaniline (0.185 g, 1.0 mmol), 5-Trifluoromethyl-2-pyridinecarboxylic acid (0.191 g, 1.0 mmol) was dissolved in 30 mL of dichloromethane. Add triethylamine (0.202 g, 2.0 mmol), then EDCI (0.287 g, 1.5 mmol) was added. HOBt (0.20g, 1.5mmol), After reacting at 25 C for 6 h, after the reaction was completed by TLC, the reaction solution was washed three times with water. The organic layer was collected and the organic layer was dried over anhydrous sodium sulfate. Desolvation, the crude product was purified by column chromatography to give a dark green solid. M.p. 78-80 C, yield 92%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,80194-69-0, its application will become more common.

Reference:
Patent; Shanghai Kaiai Network Technology Co., Ltd.; Xu Liyong; (7 pag.)CN108516955; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 80194-69-0, 5-(Trifluoromethyl)picolinic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 80194-69-0, blongs to pyridine-derivatives compound. Recommanded Product: 80194-69-0

Example 28 N-(3-((2R,5R)-6-amino-3,3,5-trifluoro-2,5-dimethyl-2,3,4,5-tetrahydropyridin-2-yl)-4-fluorophenyl)-5-(trifluoromethyl)picolinamide Prepared from (3R,6R)-6-(5-amino-2-fluorophenyl)-3,5,5-trifluoro-3,6-dimethylpiperidine-2-thione and 5-(trifluoromethyl)picolinic acid LC-MS (m/z) 463 (MH+) tR=0.61 minutes (Method A) 1H NMR (600 MHz, DMSO-d6) delta 10.96 (s, 1H), 9.18-9.09 (m, 1H), 8.48 (dd, J=8.3, 2.1 Hz, 1H), 8.33 (d, J=8.2 Hz, 1H), 7.89-7.81 (m, 2H), 7.17 (dd, J=11.9, 8.7 Hz, 1H), 6.58-6.29 (m, 2H), 2.62-2.52 (m, 1H), 2.31-2.16 (m, 1H), 1.77-1.66 (m, 6H)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,80194-69-0, 5-(Trifluoromethyl)picolinic acid, and friends who are interested can also refer to it.

Reference:
Patent; H. LUNDBECK A/S; Juhl, Karsten; Marigo, Mauro; Tagmose, Lena; Jensen, Thomas; US2015/232449; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem