Category: 80194-70-3

Related Products of 80194-70-3, Adding some certain compound to certain chemical reactions, such as: 80194-70-3, name is 3-Chloro-5-(trifluoromethyl)picolinonitrile,molecular formula is C7H2ClF3N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 80194-70-3.

Description 116; 3-Fluoro-5-trifluoroniethvvridine-2-carbonitrile; A suspension of cesium fluoride (9.6 g, 63 mmol) and potassium carbonate (250 mg, 1.8 mmol) in anhydrous DMSO (50 ml) under N2 was heated to 80C and Description 115 (8.7 g, 42 mmol) was added over 10 min. The reaction mixture was then heated to 95C for 20 min, cooled to 55C and poured into ice water. The mixture was extracted twice with hexane and once with DCM. The combined organic extracts were evaporated to give a solid (8 g, 100%). 1H NMR (400 MHz, CDCl3) 7.91 (1 H, d, J7.6), 8. 84 (1 H, s).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 80194-70-3, 3-Chloro-5-(trifluoromethyl)picolinonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK SHARP & DOHME LIMITED; WO2005/47279; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 80194-70-3, 3-Chloro-5-(trifluoromethyl)picolinonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 80194-70-3, blongs to pyridine-derivatives compound. Formula: C7H2ClF3N2

Add 863g of absolute ethanol to a 3L four-necked round bottom flask and cool to 0 C to 5 C.HCl gas into 4 to 5 hours, weighed found that the quality of the system after the increase of 575g stopped by the HCl gas,Hydrogen chloride in ethanol was obtained. 110 g (0.533 mol) of 2-cyano-3-chloro-5-trifluoromethylpyridine was addedThe pyridine was dissolved in 15 g of ethanol, added dropwise to the above system at 30 C and stirred at 30 C3 hours. The system was warmed to 45 C and the reaction stirred at 45 C for 12 hours. The system was warmed to 75 C~ 80 , and the reaction was stirred at 75 ~ 80 for 4 hours. Concentrate the ethanol, and add 300mL of water,The mixture was stirred at 25 C to 30 C for 2 hours. The resulting system was extracted with 3 × 300 mL of dichloromethane,The combined organic layers were washed with 100 mL of saturated aqueous sodium bicarbonate until neutral. Concentrate diluted dichloromethaneThe residue was distilled under reduced pressure to collect the distillate from 120 C to 130 C and from 5 mmHg to 8 mmHg118.3 g of a colorless liquid was obtained in a yield of 87.6% and a GC purity of 99.58%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,80194-70-3, its application will become more common.

Reference:
Patent; Lianhua Technology Co., Ltd.; Zou Benli; Xu Tinghua; Yuan Li; Tan Wenping; Xie Siwei; (13 pag.)CN106905231; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem