Category: 81167-60-4

Adding a certain compound to certain chemical reactions, such as: 81167-60-4, 4-(tert-Butyl)-2-chloropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 81167-60-4, blongs to pyridine-derivatives compound. category: pyridine-derivatives

A mixture of 2-chloro-4-terbutylpyridine (1.79 g, 10.5 mmol), 2,6-difluoro-3-pyridylboronic acid (2.6 g, 16.4 mmol), Pd(PPh3)4 (400 mg, 0.35 mmol), 2M aqueous solution of potassium carbonate (25 ml, 50 mmol) and 1,4-dioxane (80 ml) was deaerated by bubbling nitrogen through the mixture for 15 minutes. The mixture was stirred at 70C (bath) for 15 hours. The mixture was evaporated to a volume of approximately 30 ml. The residue was extracted with hexane (2 X 30 mL). The organic layers were washed with brine (20 mL) and dried over MgS04. After the evaporation of the solvent the product was purified by column chromatography (silicagel, ethyl acetate/hexane 1/2) and dried in high vacuum at room temperature. Yield 2.3 g, 88 %.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,81167-60-4, its application will become more common.

Reference:
Patent; CAMBRIDGE DISPLAY TECHNOLOGY LIMITED; SUMITOMO CHEMICAL COMPANY LIMITED; STEUDEL, Annette; KOZHEVNIKOV, Valery; WO2014/9716; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.81167-60-4, name is 4-(tert-Butyl)-2-chloropyridine, molecular formula is C9H12ClN, molecular weight is 169.6513, as common compound, the synthetic route is as follows.81167-60-4

2-Chloro-4-tert-butylpyridine (19.92 grams, 0.1 174 mol), 3- chlorophenylboronic acid (20.17 grams, 0.1290 mol), water (332 ml.), potassium carbonate (45.65 grams, 0.3303 mol), and monoglyme (332 ml.) were combined and sparged with nitrogen 45 minutes. Tetrakistriphenylphosphinepalladium(O) (4.98 grams, 5.746 mmol) was quickly added and the mixture was heated to reflux overnight. The mixture was concentrated by rotary evaporation to remove the monoglyme. Dichloromethane (“DCM”) was added and extracted with water several times then preabsorbed to solid media. Silica chromatography with DCM and hexanes was used to purify the product which was concentrated to 27 grams of yellow oil.

Statistics shows that 81167-60-4 is playing an increasingly important role. we look forward to future research findings about 4-(tert-Butyl)-2-chloropyridine.

Reference:
Patent; E. I. DU PONT DE NEMOURS AND COMPANY; HERRON, Norman; GAO, Weiying; WO2013/142634; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem