Reference of 811801-40-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.811801-40-8, name is (3-((Pyridin-4-ylthio)methyl)phenyl)methanol, molecular formula is C13H13NOS, molecular weight is 231.31, as common compound, the synthetic route is as follows.
EXAMPLE 8 6,7-dichloro-2-cyclopentyl-2-methyl-5-({3-[(pyridin-4-ylthio)methyl]benzyl}oxy)indan-l-oneDitertbutylazodicarboxylate (129 mg, 0.56 mmol) was added to a stirred solution of 6,7- Dichloro^-cyclopentyl-S-hydroxy^-methylindan-l-one (500 mg, 1 mmol), {3-[(pyridin-4- ylthio)methyl]phenyl}methanol (65 mg, 0.28 mmol) and triphenylphosphine (147 mg, 0.56 mmol) in tetrahydrofuran (5 mL) at rt. The reaction mixture was stirred for 16 hr, then the solvent was removed in vacuo. The residue was purified via column chromatography on silica gel (eluting 0-80% ethyl acetate/hexanes) to give 6,7-dichloro-2-cyclopentyl-2-methyl-5-({3-[(pyridin-4- ylthio)methyl]benzyl}oxy)indan-l-one as a colorless oil. 1H NMR(CDCl3, 500MHz), ? 8.39 (d, 2H), 7.56-7.40 (m, 4H), 7.13 (d, 2H), 6.91 (s, IH), 5.23 (s, 2H), 4.26 (s, 2H), 2.97 (d, IH), 2.67 (d, IH), 2.26- 2.22 (m, IH), 1.88-1.83 (m, IH), 1.56-1.48 (m, 5H), 1.28-1.20 (m, 4H), 0.94-0.92 (m, IH). MS (ESI): 513 (M + H)+.
The chemical industry reduces the impact on the environment during synthesis 811801-40-8, I believe this compound will play a more active role in future production and life.
Reference:
Patent; MERCK & CO., INC.; WO2006/47237; (2006); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem