Category: 81565-19-7

Beaulieu, Pierre L. published the artcileStructure-based design of novel HCV NS5B thumb pocket 2 allosteric inhibitors with submicromolar gt1 replicon potency: Discovery of a quinazolinone chemotype, HPLC of Formula: 81565-19-7, the main research area is crystal structure quinazolinone preparation hepatitis virus polymerase inhibitor antiviral.

The authors describe the structure-based design of a novel lead chemotype that binds to thumb pocket 2 of HCV NS5B polymerase and inhibits cell-based gt1 subgenomic reporter replicons at sub-micromolar concentrations (EC50 <200 nM). This new class of potent thumb pocket 2 inhibitors features a 1H-quinazolin-4-one scaffold derived from hybridization of a previously reported, low affinity thiazolone chemotype with the recently described anthranilic acid series. Guided by x-ray structural information, a key NS5B-ligand interaction involving the carboxylate group of anthranilic acid based inhibitors was replaced by a neutral two-point hydrogen bonding interaction between the quinazolinone scaffold and the protein backbone. The in vitro ADME and in vivo rat PK profile of representative analogs are also presented and provide areas for future optimization of this new class of HCV polymerase inhibitors. Bioorganic & Medicinal Chemistry Letters published new progress about Antiviral agents. 81565-19-7 belongs to class pyridine-derivatives, name is 3-Chloro-4-(trifluoromethyl)pyridine, and the molecular formula is C6H3ClF3N, HPLC of Formula: 81565-19-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Tran, Gael published the artcileBase-Controlled Completely Selective Linear or Branched Rhodium(I)-Catalyzed C-H ortho-Alkylation of Azines without Preactivation, Application of 3-Chloro-4-(trifluoromethyl)pyridine, the main research area is base controlled rhodium catalyzed regioselective alkylation azine acrylate acrylamide; C−H activation; homogeneous catalysis; nitrogen heterocycles; regioselectivity.

A [RhI]/bisphosphine/base catalytic system for the ortho-selective C-H alkylation of azines by acrylates and acrylamides is reported. This catalytic system features an unprecedented complete linear or branched selectivity that is solely dependent on the catalytic base that is used [e.g., 3-(trifluoromethyl)pyridine + N,N-dimethylacrylamide �linear product I when KOPiv was used as base vs. branched product II when K3PO4 was used under otherwise identical conditions]. Complete branched selectivity is even achieved for Et methacrylate, which enables the introduction of a quaternary carbon center. Excellent functional group compatibility is demonstrated for both linear and branched alkylations. The operational simplicity and broad scope of this transformation allow for rapid access to functionalized azines of direct pharmaceutical and agrochem. relevance.

Angewandte Chemie, International Edition published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent) (acrylates and acrylamides). 81565-19-7 belongs to class pyridine-derivatives, name is 3-Chloro-4-(trifluoromethyl)pyridine, and the molecular formula is C6H3ClF3N, Application of 3-Chloro-4-(trifluoromethyl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 81565-19-7, name is 3-Chloro-4-(trifluoromethyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 3-Chloro-4-(trifluoromethyl)pyridine

Step A. 3-Chloro-4-(trifluoromethyl)pyridine 1-oxide A mixture of 3-chloro-4-(trifluoromethyl)pyridine (2.00 g, 11.0 mmol) and H2O2 (3.2 mL, 31 mmol) in AcOH (6 mL) was stirred at 80 C. overnight. The reaction mixture was allowed to cool to ambient temperature and quenched with NaHSO3 solution. The mixture was concentrated under reduced pressure and the residue was added saturated NaHCO3 solution (30 mL). The resulting mixture was extracted with DCM (3 times). The combined organic phases were washed with aq. NaHCO3, water and brine, dried over Na2SO4 and concentrated under reduced pressure to give 2.11 g (97% yield) of the sub-title compound as a pink solid. LCMS calc. for C6H4ClF3NO (M+H)+: m/z=198.0. found: 198.0.

With the rapid development of chemical substances, we look forward to future research findings about 81565-19-7.

Reference:
Patent; INCYTE CORPORATION; Li, Yun-Long; Burns, David M.; Feng, Hao; Huang, Taisheng; Mei, Song; Pan, Jun; Vechorkin, Oleg; Ye, Hai-Fen; Zhu, Wenyu; Rafalski, Maria; Wang, Anlai; Xue, Chu-Biao; US2015/57265; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 81565-19-7, name is 3-Chloro-4-(trifluoromethyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 3-Chloro-4-(trifluoromethyl)pyridine

Step A. 3-Chloro-4-(trifluoromethyl)pyridine 1-oxide A mixture of 3-chloro-4-(trifluoromethyl)pyridine (2.00 g, 11.0 mmol) and H2O2 (3.2 mL, 31 mmol) in AcOH (6 mL) was stirred at 80 C. overnight. The reaction mixture was allowed to cool to ambient temperature and quenched with NaHSO3 solution. The mixture was concentrated under reduced pressure and the residue was added saturated NaHCO3 solution (30 mL). The resulting mixture was extracted with DCM (3 times). The combined organic phases were washed with aq. NaHCO3, water and brine, dried over Na2SO4 and concentrated under reduced pressure to give 2.11 g (97% yield) of the sub-title compound as a pink solid. LCMS calc. for C6H4ClF3NO (M+H)+: m/z=198.0. found: 198.0.

With the rapid development of chemical substances, we look forward to future research findings about 81565-19-7.

Reference:
Patent; INCYTE CORPORATION; Li, Yun-Long; Burns, David M.; Feng, Hao; Huang, Taisheng; Mei, Song; Pan, Jun; Vechorkin, Oleg; Ye, Hai-Fen; Zhu, Wenyu; Rafalski, Maria; Wang, Anlai; Xue, Chu-Biao; US2015/57265; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 81565-19-7, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 81565-19-7 as follows.

(3) The title compound was obtained from 3-chloro-4- trifluoromethylpyridine by the method described in Eur . J . Org . Chem., (2004), 3793.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,81565-19-7, its application will become more common.

Reference:
Patent; TAISHO PHARMACEUTICAL CO., LTD.; WO2008/18639; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 81565-19-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.81565-19-7, name is 3-Chloro-4-(trifluoromethyl)pyridine, molecular formula is C6H3ClF3N, molecular weight is 181.5429, as common compound, the synthetic route is as follows.

In a 1000 ml four-necked flask equipped with a thermometer and a dropping funnel, 33.3 g (0.314 mol) of sodium carbonate and 133.2 g of tap water were charged, and after stirring for 10 minutes, 120 ml of toluene was added, and aminoacetonitrile hydrochloride was 21.79 g (0.235). Mol), then the temperature is lowered to 10 C under stirring, and the dropwise addition of 4-(trifluoromethyl)nicotinyl chloride solution is started. The addition is completed in about 3 hours, the temperature is maintained at 10-15 C, and the addition is completed. After incubation at 30 C for 2 hours, the reaction was completed, filtered, and the product was washed with 30 ml of water to obtain a white solid product, N-cyanomethyl-4-(trifluoromethyl)nicotinamide.The purity was 99.8%, and the yield was 93.2% based on 4-(trifluoromethyl)nicotinic acid.

The chemical industry reduces the impact on the environment during synthesis 81565-19-7, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Shandong Zhanhua Yonghao Pharmaceutical Technology Co., Ltd.; Ni Zheng; (7 pag.)CN108892638; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem