Category: 81803-60-3

Related Products of 81803-60-3 , The common heterocyclic compound, 81803-60-3, name is Ethyl imidazo[1,5-a]pyridine-3-carboxylate, molecular formula is C10H10N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Ethyl imidazo[1 ,5-a]pyridine-3-carboxylate (25 mg, 0.13 mmol), (f?)-1-(2-fluorophenyl)- 4,5,6,7-tetrahydro-1 H-indazol-4-amine hydrochloride (S15) (49 mg, 0.18 mmol) and bis(trimethylaluminum)-1 ,4-diazabicyclo[2.2.2]octane adduct (51 mg, 0.20 mmol) were dissolved in THF (2 ml). The reaction mixture was stirred at 60C for 5 h under nitrogen atmosphere. The solvent was removed at reduced pressure and DCM and brine were added. The phases were separated and the organic phase was filtered and concentrated. The mixture was purified by column chromatography eluting with a gradient of EtOAc in hexanes (20-70%) to give the title compound, 31 mg (62%). 1H NMR (400 MHz, CDCI3) delta 9.54 (d, J = 8.2 Hz, 1 H), 7.71 (s, 1 H), 7.57 (d, J = 9.1 Hz, 1 H), 7.53 (d, J = 7.7 Hz, 1 H), 7.48 (td, J = 7.7, 1.7 Hz, 1 H), 7.45 (d, J = 0.7 Hz, 1 H), 7.44-7.37 (m, 1 H), 7.30-7.20 (m, 2H, overlapping with the solvent peak), 6.98 (ddd, J = 9.1 , 6.6, 1.0 Hz, 1 H), 6.85 (ddd, J = 7.2, 6.6, 1.3 Hz, 1 H), 5.43-5.32 (m, 1 H), 2.68-2.49 (m, 2H), 2.22-2.09 (m, 1 H), 2.03-1.82 (m, 3H). m/z (ES+) 376 [M+H]+.

The synthetic route of 81803-60-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LAIN, Sonia; DRUMMOND, Catherine; LEEUWEN, Ingeborg van; HARALDSSON, Martin; JOHANSSON, Lars; SANDBERG, Lars; YNGVE, Ulrika; (126 pag.)WO2017/77280; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 81803-60-3 , The common heterocyclic compound, 81803-60-3, name is Ethyl imidazo[1,5-a]pyridine-3-carboxylate, molecular formula is C10H10N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Ethyl imidazo[1 ,5-a]pyridine-3-carboxylate (25 mg, 0.13 mmol), (f?)-1-(2-fluorophenyl)- 4,5,6,7-tetrahydro-1 H-indazol-4-amine hydrochloride (S15) (49 mg, 0.18 mmol) and bis(trimethylaluminum)-1 ,4-diazabicyclo[2.2.2]octane adduct (51 mg, 0.20 mmol) were dissolved in THF (2 ml). The reaction mixture was stirred at 60C for 5 h under nitrogen atmosphere. The solvent was removed at reduced pressure and DCM and brine were added. The phases were separated and the organic phase was filtered and concentrated. The mixture was purified by column chromatography eluting with a gradient of EtOAc in hexanes (20-70%) to give the title compound, 31 mg (62%). 1H NMR (400 MHz, CDCI3) delta 9.54 (d, J = 8.2 Hz, 1 H), 7.71 (s, 1 H), 7.57 (d, J = 9.1 Hz, 1 H), 7.53 (d, J = 7.7 Hz, 1 H), 7.48 (td, J = 7.7, 1.7 Hz, 1 H), 7.45 (d, J = 0.7 Hz, 1 H), 7.44-7.37 (m, 1 H), 7.30-7.20 (m, 2H, overlapping with the solvent peak), 6.98 (ddd, J = 9.1 , 6.6, 1.0 Hz, 1 H), 6.85 (ddd, J = 7.2, 6.6, 1.3 Hz, 1 H), 5.43-5.32 (m, 1 H), 2.68-2.49 (m, 2H), 2.22-2.09 (m, 1 H), 2.03-1.82 (m, 3H). m/z (ES+) 376 [M+H]+.

The synthetic route of 81803-60-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LAIN, Sonia; DRUMMOND, Catherine; LEEUWEN, Ingeborg van; HARALDSSON, Martin; JOHANSSON, Lars; SANDBERG, Lars; YNGVE, Ulrika; (126 pag.)WO2017/77280; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 81803-60-3, Ethyl imidazo[1,5-a]pyridine-3-carboxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 81803-60-3, blongs to pyridine-derivatives compound. Recommanded Product: 81803-60-3

2-(Aminomethyl)pyridine (1.5 g, 13.9 mmol) and pyridine (5.55 g, 59.6 mmol) were dissolved in MeCN (30 mL), and the solution was cooled by using an ice bath. A solution of ethyl oxalyl chloride (1.89 g, 13.9 mmol) in MeCN (10 mL) was added dropwise at 0 to -5 C. After the addition, the mixture was stirred for 2 h and a solution of TFAA (6.41 g, 30.5 mmol) in MeCN (15 mL) was added dropwise at -15 to -10 C (ice-salt bath). The reaction mixture was allowed to stand overnight in the bath, then the mixture was poured in sat. aq sodium hydrocarbonate, filtered, and washed with water. Yield: 3.77 g (95%); yellow solid; mp 225 C. 1H NMR (DMSO-d6): delta = 1.40 (t, J = 6.6 Hz, 3 ), 4.48 (q, J = 6.6 Hz, 2 H), 7.51 (t, J = 6.6 Hz, 1 H), 7.86 (t, J = 7.6 Hz, 1 H), 8.40 (d, J = 8.8 Hz,1 H), 9.45 (d, J = 6.6 Hz, 1 H). 13C NMR (DMSO-d6): delta = 14.2, 61.7, 116.6 (q, 1JC-F = 290.7 Hz), 118.5, 118.6, 123.1, 128.0, 129.1, 132.2, 139.0, 158.4, 172.9 (q, 2JC-F = 33.9 Hz). MS: m/z (%) = 288 (14) [M + 2]+, 287 (100) [M + 1]+, 259 (3) [M + 2 -CO]+, 242 (3) [M + 2 – C2H5OH]+, 241 (23) [M + 1 – C2H5OH]+.

The synthetic route of 81803-60-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Tverdiy, Dmytro O.; Chekanov, Maksym O.; Savitskiy, Pavlo V.; Syniugin, Anatolii R.; Yarmoliuk, Sergiy M.; Fokin, Andrey A.; Synthesis; vol. 48; 23; (2016); p. 4269 – 4277;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 81803-60-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.81803-60-3, name is Ethyl imidazo[1,5-a]pyridine-3-carboxylate, molecular formula is C10H10N2O2, molecular weight is 190.2, as common compound, the synthetic route is as follows.

Under hydrogen a solution of ethyl imidazo[1,5-a]pyridine-3-carboxylate (300 mg, 1.58 mmol,1.00 equiv) and Pd/C (10 wt%, 30 mg) in methanol (20 mL) was stirred for 30 h at room temperature. After filtration the filtrate was collected and concentrated under vacuum. This resulted in 325 mg of the title compound (crude) as a white solid. LC-MS (ES, mlz): 195 [M+H].

The chemical industry reduces the impact on the environment during synthesis 81803-60-3, I believe this compound will play a more active role in future production and life.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; BLAQUIERE, Nicole; BURCH, Jason; CASTANEDO, Georgette; FENG, Jianwen A.; HU, Baihua; STABEN, Steven; WU, Guosheng; YUEN, Po-wai; WO2015/25025; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 81803-60-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.81803-60-3, name is Ethyl imidazo[1,5-a]pyridine-3-carboxylate, molecular formula is C10H10N2O2, molecular weight is 190.2, as common compound, the synthetic route is as follows.

Under hydrogen a solution of ethyl imidazo[1,5-a]pyridine-3-carboxylate (300 mg, 1.58 mmol,1.00 equiv) and Pd/C (10 wt%, 30 mg) in methanol (20 mL) was stirred for 30 h at room temperature. After filtration the filtrate was collected and concentrated under vacuum. This resulted in 325 mg of the title compound (crude) as a white solid. LC-MS (ES, mlz): 195 [M+H].

The chemical industry reduces the impact on the environment during synthesis 81803-60-3, I believe this compound will play a more active role in future production and life.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; BLAQUIERE, Nicole; BURCH, Jason; CASTANEDO, Georgette; FENG, Jianwen A.; HU, Baihua; STABEN, Steven; WU, Guosheng; YUEN, Po-wai; WO2015/25025; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 81803-60-3 ,Some common heterocyclic compound, 81803-60-3, molecular formula is C10H10N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To an ice cold solution of ethyl imidazo[l,5-alpha]pyridine-3-carboxylate (10 g, 52.6 mmol) in acetonitrile (500 mL) was added N-bromo succinimide (9.36 g, 52.6 mmol). The mixture was allowed to stir for 1 h at which time triethylamine (10 mL) was added to the deep red- violet solution. The color dissipated and the solution was concentrated. Purification of the crude solid by silica gel chromatography (0-20% EtOAc/Hexanes) provided a white crystalline solid (13.5 g 95%). MS 268.9 (M + 1)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,81803-60-3, its application will become more common.

Reference:
Patent; MERCK & CO., INC.; WO2008/85302; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 81803-60-3 ,Some common heterocyclic compound, 81803-60-3, molecular formula is C10H10N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To an ice cold solution of ethyl imidazo[l,5-alpha]pyridine-3-carboxylate (10 g, 52.6 mmol) in acetonitrile (500 mL) was added N-bromo succinimide (9.36 g, 52.6 mmol). The mixture was allowed to stir for 1 h at which time triethylamine (10 mL) was added to the deep red- violet solution. The color dissipated and the solution was concentrated. Purification of the crude solid by silica gel chromatography (0-20% EtOAc/Hexanes) provided a white crystalline solid (13.5 g 95%). MS 268.9 (M + 1)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,81803-60-3, its application will become more common.

Reference:
Patent; MERCK & CO., INC.; WO2008/85302; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 81803-60-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.81803-60-3, name is Ethyl imidazo[1,5-a]pyridine-3-carboxylate, molecular formula is C10H10N2O2, molecular weight is 190.2, as common compound, the synthetic route is as follows.

To a solution of ethyl imidazo[1,5-a]pyridine-3-carboxylate (152 mg) in Acetic Acid (0.25M) was added Bromine (leq). The reaction was stirred at room temperature for 5 minutes thenconcentrated to dryness to give 205 of the title compound. This intermediate was taken onto the next step without purification.

The chemical industry reduces the impact on the environment during synthesis 81803-60-3, I believe this compound will play a more active role in future production and life.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; BLAQUIERE, Nicole; BURCH, Jason; CASTANEDO, Georgette; FENG, Jianwen A.; HU, Baihua; STABEN, Steven; WU, Guosheng; YUEN, Po-wai; WO2015/25025; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 81803-60-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.81803-60-3, name is Ethyl imidazo[1,5-a]pyridine-3-carboxylate, molecular formula is C10H10N2O2, molecular weight is 190.2, as common compound, the synthetic route is as follows.

To a solution of ethyl imidazo[1,5-a]pyridine-3-carboxylate (152 mg) in Acetic Acid (0.25M) was added Bromine (leq). The reaction was stirred at room temperature for 5 minutes thenconcentrated to dryness to give 205 of the title compound. This intermediate was taken onto the next step without purification.

The chemical industry reduces the impact on the environment during synthesis 81803-60-3, I believe this compound will play a more active role in future production and life.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; BLAQUIERE, Nicole; BURCH, Jason; CASTANEDO, Georgette; FENG, Jianwen A.; HU, Baihua; STABEN, Steven; WU, Guosheng; YUEN, Po-wai; WO2015/25025; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 81803-60-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.81803-60-3, name is Ethyl imidazo[1,5-a]pyridine-3-carboxylate, molecular formula is C10H10N2O2, molecular weight is 190.2, as common compound, the synthetic route is as follows.

To a solution of ethyl imidazo[1,5-a]pyridine-3-carboxylate (152 mg) in Acetic Acid (0.25M) was added Bromine (leq). The reaction was stirred at room temperature for 5 minutes thenconcentrated to dryness to give 205 of the title compound. This intermediate was taken onto the next step without purification.

The chemical industry reduces the impact on the environment during synthesis 81803-60-3, I believe this compound will play a more active role in future production and life.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; BLAQUIERE, Nicole; BURCH, Jason; CASTANEDO, Georgette; FENG, Jianwen A.; HU, Baihua; STABEN, Steven; WU, Guosheng; YUEN, Po-wai; WO2015/25025; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem