Category: 82205-58-1

Synthetic Route of 82205-58-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 82205-58-1, name is 1-(5-Nitropyridin-2-yl)piperazine. A new synthetic method of this compound is introduced below.

Step 3: 4-(5-Nitropyridin-2-yl)-N-(2-fluorophenyl)piperazine-l-carboxamide (B-4)To compound B-3 (6.6 g, 32 mmol) dissolved in dry THF (200 mL) was added triethylamine (8.8 mL, 63 mmol) and 2-fluorophenyl isocyanate (4.3 mL, 38 mmol). The resulting reaction mixture was heated at 80 C for 16 h then cooled to RT and concentrated. Water (150 mL) was added, and the aqueous solution was extracted with CH2CI2. The combined organic extract was dried (MgS04), filtered, and concentrated to give a yellow solid. The solid was triturated with water, filtered, and dried to give the product 4-(5-nitropyridin-2-yl)-N-(2- fluorophenyl)piperazine-l-carboxamide (B-4) as a yellow solid (11.4 g, 100% yield). MS (M+1): 346.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,82205-58-1, its application will become more common.

Reference:
Patent; SCHERING CORPORATION; TING, Pauline, C.; LEE, Joe, F.; ASLANIAN, Robert, G.; WO2011/31628; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 82205-58-1, 1-(5-Nitropyridin-2-yl)piperazine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C9H12N4O2, blongs to pyridine-derivatives compound. HPLC of Formula: C9H12N4O2

To a stirred solution of 5-nitro-2-piperazinyl-pyridine (10.1 g) and potassium carbonate (20.29 g) in acetone (500 mL) was added portionwise 3-cyano-benzyl bromide (9.6 g) and the mixture was heated under reflux during 2 hours. The salts were removed by filtration, washed with acetone and the filtrate was evaporated to dryness. The residue was taken in CH2Cl2, and the solution washed with water, dried over Na2SO4, filtered and evaporated under reduced pressure to leave an oil which crystallized by trituration with diisopropyl oxyde. The title compound was obtained as a yellow solid (14.4 g). [0245] m.p.: 103-105 C.

The synthetic route of 82205-58-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Dodic, Nerina; US2004/9988; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 82205-58-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 82205-58-1, name is 1-(5-Nitropyridin-2-yl)piperazine, molecular formula is C9H12N4O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(General acetylation/sulphonylation procedure). Compound 3b (208 mg, 1 mmol), acetyl chloride (79 mul, 1.1 mmol) and PS-NMM (100 mg) in CH2Cl2 (5 mL) were stirred for 16 h. After adding PS-Trisamine (150 mg) to the reaction mixture was left to stir for a further 2 h, filtered and concentrated in vacuum to afford a yellow solid: 250 mg (90%) yield.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 82205-58-1, 1-(5-Nitropyridin-2-yl)piperazine.

Reference:
Article; Spencer, John; Patel, Hiren; Callear, Samantha K.; Coles, Simon J.; Deadman, John J.; Tetrahedron Letters; vol. 52; 45; (2011); p. 5905 – 5909;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 82205-58-1 , The common heterocyclic compound, 82205-58-1, name is 1-(5-Nitropyridin-2-yl)piperazine, molecular formula is C9H12N4O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 86Synthesis of 4-[5-(acetylamino)pyridin-2-yl]piperazin-l-yl-5-(4~ fluorophenyl)-6-[4-(methylsulfonyl)phenyl]-2-(trifluoromethyl)pyrimidine4-Chloro-5-(4-fluorophenyl)-6-[4-(methylsulfonyl)phenyl]-2-(trifluoro methyl)pyrimidine (0.15g, 0.35mmol) was treated with l-(5-nitropyridin-2- yl)?iperazine (0.087g, 0.418mmol) and diisopropylethylamine (0.06mL, 0.35mmol), acetonitrile (2.5mL) and heated at 60-650C for 2 hours. Subsequently the reaction mixture was precipitated by the addition of diisopropyl ether (2mL). The above-obtained solid (0.1 Ig, 0.182mmol) was taken up in acetic acid (2mL) and tin (II) chloride dihydrate (0.123g, 0.182mmol) was added to it. Stirring was continued further for 11 hours, and then the reaction mixture was poured onto ice-cold water, and extracted with ethyl acetate (25mL x 2). After neutralization with sodium bicarbonate, the organic layer was evaporated to obtain the crude material, which was purified by column chromatography (2% MeOH in dichloromethane) to yield the title compound. 1H-NMR (DMSOd6) ?: 1.99 (s, 3H), 3.19 (s, 3H), 3.29 – 3.40 (m, 8H), 6.77 (d, IH), 7.19 – 7.23 (m, 2H), 7.31 – 7.34 (m, 2H), 7.36 (d, 2H), 7.74 (d, IH)5 7.80 (d, 2H), 8.24 (d, IH), 9.77 (s, IH, D2O exchangeable). MS m/z: 615.1 (M++l).

The synthetic route of 82205-58-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ORCHID RESEARCH LABORATORIES LIMITED; WO2007/83182; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 82205-58-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 82205-58-1, name is 1-(5-Nitropyridin-2-yl)piperazine. A new synthetic method of this compound is introduced below.

(General acetylation/sulphonylation procedure). Compound 3b (208 mg, 1 mmol), acetyl chloride (79 mul, 1.1 mmol) and PS-NMM (100 mg) in CH2Cl2 (5 mL) were stirred for 16 h. After adding PS-Trisamine (150 mg) to the reaction mixture was left to stir for a further 2 h, filtered and concentrated in vacuum to afford a yellow solid: 250 mg (90%) yield.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,82205-58-1, 1-(5-Nitropyridin-2-yl)piperazine, and friends who are interested can also refer to it.

Reference:
Article; Spencer, John; Patel, Hiren; Callear, Samantha K.; Coles, Simon J.; Deadman, John J.; Tetrahedron Letters; vol. 52; 45; (2011); p. 5905 – 5909;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 82205-58-1, 1-(5-Nitropyridin-2-yl)piperazine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyridine-derivatives, blongs to pyridine-derivatives compound. category: pyridine-derivatives

Step 3: l-(5-Nitropyridin-2-yl)-4-[2-(trifluoromethyl)benzoyl]piperazine: To a stirred solution of 2-(trifluoromethyl)benzoic acid (16.45 g, 86.538 mmol) in dry dichloromethane (150 ml) was added l-(3-dimethylaminopropyl)3-ethylcarbodiimide hydrochloride (14.61 g, 108.172 mmol), 1-hydroxybenzotriazole (11.04 g, 72.115 mmol) and triethylamine (35.113 ml, 252.40 mmol) at 0 “C. After 30 minutes at the same temperature, the Step 2 intermediate (15.00 g, 72.115 mmol) was added and the mixture was slowly allowed to warm to room temperature. The mixture was further stirred overnight at room temperature. The reaction mixture was diluted with dichloromethane (200 ml) and washed with water (2 x 100 ml) and dried over anhydrous Na2SO4. The residue after evaporation of the solvent was triturated with n-pentane to afford 23.4 g of the desired product as a pale yellow solid; IR (KBr) 3435, 3117, 2991, 1641, 1250, 774 cm4; 1H NMR (CDCl3, 300 MHz) delta 3.26-3.40 (m, 2H), 3.65-3.98 (m, 5H), 4.00-4.10 (m, IH), 6.60 (d, J= 9.3 Hz, IH), 7.37 (d, J= 7.5 Hz, IH), 7.51-7.70 (m, 2H), 7.75 (d, J- 7.5 Hz, IH), 8.24 (dd, J= 6.9, 2.7 Hz, IH), 9.03 (d, J= 2.7 Hz, IH); MS (ESI) m/z 381.37 (MH)+.

The synthetic route of 82205-58-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GLENMARK PHARMACEUTICALS S.A.; WO2008/29266; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 82205-58-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 82205-58-1, name is 1-(5-Nitropyridin-2-yl)piperazine, molecular formula is C9H12N4O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(General acetylation/sulphonylation procedure). Compound 3b (208 mg, 1 mmol), acetyl chloride (79 mul, 1.1 mmol) and PS-NMM (100 mg) in CH2Cl2 (5 mL) were stirred for 16 h. After adding PS-Trisamine (150 mg) to the reaction mixture was left to stir for a further 2 h, filtered and concentrated in vacuum to afford a yellow solid: 250 mg (90%) yield. 1H NMR CDCl3 delta = 9.03 (1H, d, J = 2.5 Hz), 8.23 (1H, dd, J1, J2 = 2.9 Hz), 6.59 (1H, d, J = 9.5 Hz), 3.89-3.58 (8H, m), 2.13 (3H, s). 13C NMR CDCl3 delta = 169.4, 160.2, 146.2, 135.5, 133.2, 104.7, 44.7 (2C), 44.3 (2C), 21.4. IR (neat, cm-1): 1643, 1596, 1512, 1424, 1340, 1299, 929. HRMS m/z calculated for C11H15N4O3 (MH+): 251.1139, Found: 251.1140.

According to the analysis of related databases, 82205-58-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Spencer, John; Patel, Hiren; Callear, Samantha K.; Coles, Simon J.; Deadman, John J.; Tetrahedron Letters; vol. 52; 45; (2011); p. 5905 – 5909;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem