Category: 82257-15-6

Reference of 82257-15-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.82257-15-6, name is 4-Methoxypyridine-3-carboxaldehyde, molecular formula is C7H7NO2, molecular weight is 137.14, as common compound, the synthetic route is as follows.

General procedure: Method F: Synthesis of (Z)-2-(6-X-lH-indol-3-yl)-3-(4-methoxypyridin-3- yl)acrylonitrile To a solution of tert-butyl 6-X-3-(cyanomethyl)-lH-indole-l-carboxylate(l eq) in THF, was added NaH (eq). The resulting mixture was stirred 10 min at room temperature and 4-methoxynicotinaldehyde (1.3 eq) was added with one drop of DMF. The mixture was stirred at room temperature hidden from light. The reaction was quenched with aqueous NH4C1 and extracted with AcOEt, dried over Na2S04, filtrated and concentrated. The residue was dissolved with THF and NaOH 2.5 M was added. The system was stirred at room temperature hidden from light, diluted with AcOEt, dried over Na2S04, filtrated and concentrated. The residue was taken off with a minimal amount of AcOEt and filtrated to give the title compound.

Statistics shows that 82257-15-6 is playing an increasingly important role. we look forward to future research findings about 4-Methoxypyridine-3-carboxaldehyde.

Reference:
Patent; BIOKINESIS; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; BOUGERET, Cecile; GUILLOU, Catherine; ROULEAU, Julien; RIVOLLIER, Julie; CARNIATO, Denis; WO2014/86964; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 82257-15-6, 4-Methoxypyridine-3-carboxaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 4-Methoxypyridine-3-carboxaldehyde, blongs to pyridine-derivatives compound. name: 4-Methoxypyridine-3-carboxaldehyde

{l-[4-(5-Amino-2-phenyl-pyrimidin-4-ylamino)-phenyl]-cyclobutyl}- carbamic acid tert-butyl ester (0.25 g, 0.58 mmol) was dissolved in acetic acid (30 mL), then 4- methoxy-pyridine-3-carbaldehyde (87.7 mg, 0.64 mmol) and Cu(OAc)2 (105 mg, 0.58 mmol) were added separately. The reaction mixture was stirred at 100 C for 2 h. The reaction mixture was concentrated under reduced pressure, and the residue was dissolved in ethyl acetate (150 mL). The organic layer was washed with aqueous sat. NaHC03 solution, followed by brine, dried over sodium sulfate, filtered and concentrated to give crude desired product (-150 mg), which was used directly without further purification. LC/MS (ESI+): e/z: 549.2 [M+l]+.

The synthetic route of 82257-15-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ARRAY BIOPHARMA INC.; GENENTECH, INC.; SKELTON, Nicholas; GRADL, Stefan; BLAKE, James F.; GRAHAM, James M.; GUNAWARDANA, Indrani W.; HENTEMANN, Martin; MARLOW, Allison L.; TANG, Tony P.; WO2013/78254; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem