Category: 823-39-2

Electric Literature of 823-39-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 823-39-2, name is 3,4-Dimethylpyridin-2-amine. A new synthetic method of this compound is introduced below.

G. (L)-N-Boc-6-methanesulfonylnorleucine allyl ester (11b) As an alternative approach, to a cooled (0 C. bath) solution of (L)-N-Boc-6-hydroxynorleucine allyl ester (10) from E above (80 mg, 0.28 mmol), triethyl amine (80 muL, 0.57 mmol), dimethyl amino pyridine (DMAP) (cat) in anhydrous CH2 Cl2 (1 mL) under N2 was added methane sulfonyl chloride (27 muL, 0.34 mmol). The contents were warmed (rt) and the mixture was concentrated under reduced pressure and purified by flash chromatography (silica gel; EtOAc/hexane, (1:19, v/v)) to provide a light yellow oil identified as (L)-N-Boc-6-methanesulfonylnorleucine allyl ester (11 b) (81 mg, 79%): TLC (SiO2, EtOAc/hexane (1:1, v/v)) Rf =0.36; 1 H NMR (360 MHz, CDCl3) delta5.98-5.84 (m, 1 H), 5.38-5.24 (m, 2 H), 5.08-4.96 (m, 1 H), 4.70-4.58 (m, 2 H), 4.38-4.26 (m, 1 H), 4.21 (t, J=6.4 Hz, 2 H), 2.99 (s, 3 H), 1.95-1.35 (m, 15 H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,823-39-2, its application will become more common.

Reference:
Patent; Keystone Biomedical, Inc.; US5952492; (1999); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 823-39-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 823-39-2, name is 3,4-Dimethylpyridin-2-amine. A new synthetic method of this compound is introduced below.

G. (L)-N-Boc-6-methanesulfonylnorleucine allyl ester (11b) As an alternative approach, to a cooled (0 C. bath) solution of (L)-N-Boc-6-hydroxynorleucine allyl ester (10) from E above (80 mg, 0.28 mmol), triethyl amine (80 muL, 0.57 mmol), dimethyl amino pyridine (DMAP) (cat) in anhydrous CH2 Cl2 (1 mL) under N2 was added methane sulfonyl chloride (27 muL, 0.34 mmol). The contents were warmed (rt) and the mixture was concentrated under reduced pressure and purified by flash chromatography (silica gel; EtOAc/hexane, (1:19, v/v)) to provide a light yellow oil identified as (L)-N-Boc-6-methanesulfonylnorleucine allyl ester (11 b) (81 mg, 79%): TLC (SiO2, EtOAc/hexane (1:1, v/v)) Rf =0.36; 1 H NMR (360 MHz, CDCl3) delta5.98-5.84 (m, 1 H), 5.38-5.24 (m, 2 H), 5.08-4.96 (m, 1 H), 4.70-4.58 (m, 2 H), 4.38-4.26 (m, 1 H), 4.21 (t, J=6.4 Hz, 2 H), 2.99 (s, 3 H), 1.95-1.35 (m, 15 H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,823-39-2, its application will become more common.

Reference:
Patent; Keystone Biomedical, Inc.; US5952492; (1999); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 823-39-2, 3,4-Dimethylpyridin-2-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 823-39-2, blongs to pyridine-derivatives compound. COA of Formula: C7H10N2

Preparation M (3beta,5alpha,25R)3-trimethylsilyloxy-spirostan-11-one Silylation of Spirostanes Trimethylsilylchloride (3.27 mL, 25.8 mmol) was added to a solution of (3beta,5alpha,25R)3-hydroxy-spirostan-11-one (4.0 g, 9.3 mmol) and triethylamine (6.5 mL, 46 mmol) in dichloromethane (60 mL) at room temperature. One gram of dimethyl aminopyridine was added and the reaction was stirred at room temperature for 12 hours. The reaction was quenched with methanol (1 mL) and diluted with ethyl acetate, washed with water (5*) and brine (1*), dried (Na2 SO4), filtered and concentrated in vacuo. The product was triturated with methanol, filtered and dried to afford 3.94 g (85percent) product as a white solid. 1 H NMR (250 MHz, CDCl3) 6 4.5 (q, 1H, J=6Hz); 3.45 (m, 2H); 2.35 (t, 1H, J=10 Hz); 2.4 (dt, 1H, J=12.2 Hz); 2.2 (s, 2H); 2.1-1.1 (m, 12H); 1.02 (s, 3H); 0.9 (d, 3H, J=7.0 Hz); 0.78 (d, 3H, J=7 Hz); 0.69 (s, 3H); 0.1 (s, 9H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,823-39-2, its application will become more common.

Reference:
Patent; Pfizer Inc.; US5939398; (1999); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 823-39-2, 3,4-Dimethylpyridin-2-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 823-39-2, blongs to pyridine-derivatives compound. COA of Formula: C7H10N2

Preparation M (3beta,5alpha,25R)3-trimethylsilyloxy-spirostan-11-one Silylation of Spirostanes Trimethylsilylchloride (3.27 mL, 25.8 mmol) was added to a solution of (3beta,5alpha,25R)3-hydroxy-spirostan-11-one (4.0 g, 9.3 mmol) and triethylamine (6.5 mL, 46 mmol) in dichloromethane (60 mL) at room temperature. One gram of dimethyl aminopyridine was added and the reaction was stirred at room temperature for 12 hours. The reaction was quenched with methanol (1 mL) and diluted with ethyl acetate, washed with water (5*) and brine (1*), dried (Na2 SO4), filtered and concentrated in vacuo. The product was triturated with methanol, filtered and dried to afford 3.94 g (85percent) product as a white solid. 1 H NMR (250 MHz, CDCl3) 6 4.5 (q, 1H, J=6Hz); 3.45 (m, 2H); 2.35 (t, 1H, J=10 Hz); 2.4 (dt, 1H, J=12.2 Hz); 2.2 (s, 2H); 2.1-1.1 (m, 12H); 1.02 (s, 3H); 0.9 (d, 3H, J=7.0 Hz); 0.78 (d, 3H, J=7 Hz); 0.69 (s, 3H); 0.1 (s, 9H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,823-39-2, its application will become more common.

Reference:
Patent; Pfizer Inc.; US5939398; (1999); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 823-39-2, name is 3,4-Dimethylpyridin-2-amine, the common compound, a new synthetic route is introduced below. Safety of 3,4-Dimethylpyridin-2-amine

Then the solid was stirred with 100 ml ethyl acetate, 150 ml ethanol and 10 ml half concentrated hydrochloric acid. The solvent volume was reduced in vacuo and the precipitate recovered by filtration, washed with diethyl ether and dried over phosphorous pentoxide. 4.97 g (0.021 Mol, 63%) of product was obtained as a white powder. 1H NMR (dDMSO): delta 6.95 ppm (s, 1H), delta 8.02 ppm (s, 1H), delta 8.67 ppm (s, 1H). To prepare 7-butyryloxy-3-carboxy-6-chlorocoumarin, 3.1 g (12.9 mMol) 3-carboxy-6-chloro-7-hydroxycoumarin were dissolved in 100 ml dioxane and treated with 5 ml butyric anhydride, 8 ml pyridine and 20 mg dimethyl aminopyridine at room temperature for two hours. The reaction solution was added with stirring to 300 ml heptane upon which a white precipitate formed. It was recovered by filtration and dissolved in 150 ml ethyl acetate. Undissolved material was removed by filtration and the filtrate extracted twice with 50 ml 1 N hydrochloric acid/brine (1:1) and then brine. The solution was dried over anhydrous sodium sulfate. Evaporation in vacuo yielded 2.63 g (8.47 mMol, 66%) of product. 1H NMR (CDCl3): delta 1.08 ppm (t, 3H, J=7.4 Hz, butyric methyl), delta 1.85 ppm (m, 2H, J1 delta J2=7.4 Hz, butyric methylene), delta 2.68 ppm (t, 2H, J=7.4 Hz, butyric methylene), delta 7.37 ppm (s, 1H, coumarin), delta 7.84 ppm (s, 1H, coumarin), delta 8.86 ppm (s, 1H, coumarin). Preparation of 7-butyryloxy-3-benzyloxycarbonylmethylaminocarbonyl-6-chlorocoumarin is effected as follows.

The synthetic route of 823-39-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Invitrogen Corporation, a Delaware corporation; US2006/8855; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem