Category: 823-56-3

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 823-56-3, name is 2-Fluoro-3,5-dichloropyridine, the common compound, a new synthetic route is introduced below. Quality Control of 2-Fluoro-3,5-dichloropyridine

5.00g (0.030 mol) of 3,5-dichloro-2-fluoropyridine and 5.01g of 1-(1- cyclohexen-l-yl)pyrrolidine (0.033 mol) are stirred neat together at room temperature for Ih and are left at room temperature overnight. The reaction mixture is quenched with 40ml of sulfuric acid 2M. Water is added to the reaction mixture (100 ml) which is extracted thrice with ethyl acetate (50 ml). The combined organic phases are washed with water (150 ml) and brine (100 ml). After separation, the organic phase is dried over magnesium sulfate filtered, concentrated to dryness and purified on silica gel to yield to 0.22 g of 2-[3,5-dichloro-2-pyridinyl]cyclohexanoneMass spectrum : [M+l] = 244.

The synthetic route of 823-56-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BAYER CROPSCIENCE SA; WO2006/122955; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 823-56-3, 2-Fluoro-3,5-dichloropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C5H2Cl2FN, blongs to pyridine-derivatives compound. Formula: C5H2Cl2FN

Example 11 Preparing 2,3-difluoro-5-chloropyridine by Reacting 2-fluoro-3,5-dichloropyridine Using tetrakis(diethylamino)phosphonium bromide A 500 ml four-necked flask which is equipped with thermometer, anchor stirrer and reflux condenser with bubble counter is charged with 166 g (1 mol) of 2-fluoro-3,5-dichloropyridine, 68.4 g (1.2 mol) of potassium fluoride and 3.99 g (0.01 mol) of tetrakis(diethylamino)phosphonium bromide. The reaction mixture is then heated with stirring to the predetermined reaction temperature and is allowed to react for the time indicated. After the end of the reaction the reaction mixture is cooled and poured into water which is employed in excess, the mixture is subjected to extraction with methylene chloride, and the isolated methylene chloride phase is washed with water, dried and then subjected to fractional distillation under reduced pressure.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,823-56-3, 2-Fluoro-3,5-dichloropyridine, and friends who are interested can also refer to it.

Reference:
Patent; Aventis Research & Technologies GmbH & Co.; US6184425; (2001); B2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 823-56-3, name is 2-Fluoro-3,5-dichloropyridine. This compound has unique chemical properties. The synthetic route is as follows. 823-56-3

5.0Og (0.030 mol) of 3,5-dichloro-2-fluoropyridine and 5.01g of 1-(1- cyclohexen-l-yl)pyrrolidine (0.033 mol) are stirred neat together at room temperature for Ih and are left at room temperature overnight. The reaction mixture is quenched with 40ml of sulfuric acid 2M. Water is added to the reaction mixture (100 ml) which is extracted thrice with ethyl acetate (50 ml). The combined organic phases are washed with water (150 ml) and brine (100 ml). After separation, the organic phase is dried over magnesium sulfate filtered, concentrated to dryness and purified on silica gel to yield to 0.22 g of 2-[3,5-dichloro-2-pyridinyl]cyclohexanone

Statistics shows that 823-56-3 is playing an increasingly important role. we look forward to future research findings about 2-Fluoro-3,5-dichloropyridine.

Reference:
Patent; BAYER CROPSCIENCE SA; WO2006/122952; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

823-56-3, Adding a certain compound to certain chemical reactions, such as: 823-56-3, 2-Fluoro-3,5-dichloropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 823-56-3, blongs to pyridine-derivatives compound.

To a mixture of methyl (lr, 4r) -4-hydroxy-2′ -oxo-1′ , 2′ – dihydrospiro [cyclohexane-1, 3′ -indole] -5′ -carboxylate (1.00 g) and tetrahydrofuran (60 ml) was added sodium hydride (60% in oil, 436 mg) at 0C, and the mixture was stirred at the same temperature for 30 min and 3, 5-dichloro-2-fluoropyridine (723 mg) was added. After stirring at room temperature for 8 hr, N, -dimethylformamide (60 ml) was added, and the mixture was further stirred at room temperature for 12 hr. The reaction mixture was poured into ice-cooled water and extracted with ethyl acetate. The organic layer was separated, washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/petroleum ether) to give a white solid. To a mixture of the obtained solid, tetrahydrofuran (20 ml) and water (20 ml) was added lithium hydroxide monphydrate (130 mg) at room temperature, and the mixture was stirred at 50C for 3 hr and concentrated under reduced pressure. The residue was adjusted to pH=3.0 by adding 3N hydrochloric acid and extracted with ethyl acetate. The organic layer was separated, washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/petroleum ether) to give the title compound (1.00 g)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,823-56-3, its application will become more common.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; TERAO, Yoshito; TAKAHASHI, Masashi; HARA, Ryoma; HIDAKA, Kousuke; FURUKAWA, Hodeki; YAMASAKI, Takeski; KASAI, Shizuo; (147 pag.)WO2018/182051; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem