Category: 824-51-1

Reference of 824-51-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 824-51-1, name is 6-Methyl-1H-pyrrolo[2,3-b]pyridine. This compound has unique chemical properties. The synthetic route is as follows.

PREPARATION 131 1 -(2-((1 ,4-Dimethyl-1 H-pyrazol-5-yl)methyl)-4-fluorophenyl)-6-methyl-1 H- pyrrolo[2,3-b]pyridine The title compound of Preparation 58 (0.150 g, 1 .13 mmol), potassium phosphate (0.48 g, 2.27 mmol) and the title compound of Preparation 130 (0.337 g, 1 .19 mmol) were suspended in 3 ml 1 ,4-dioxane in a Schlenk vessel and the mixture was subjected to three vacuum-argon cycles. Copper(l) iodide (44 mg, 0.23 mmol) and trans-N1 ,N2-dimethylcyclohexane-1 ,2-diamine (0.072 ml, 0.46 mmol) were added and the mixture was submitted to three further vacuum-argon cycles. The reaction vessel was sealed and the mixture was stirred at 130 C for 72 h. Further copper(l) iodide (22 mg, 0.12 mmol) and trans-N1 ,N2-dimethylcyclohexane-1 ,2-diamine (0.036 ml, 0.23 mmol) were added and the kixture was stirred at 130 C for 48 h. The mixture was allowed to cool to room temperature, diluted with ethyl acetate and filtered through Celite. The filtrate was evaporated under reduced pressure and the residue was purified by reverse-phase chromatography using the Isolera Purification System to give 140 mg (0.42 mmol, 37%) of the title compound as an oil. Purity 98%. 1 H N MR (300 MHz, CHLOROFORM-d) delta ppm 7.88 (d, 1 H, J = 8.2 Hz), 7.28-7.33 (m, 2H), 7.16 (d, 1 H, J = 3.5 Hz), 7.01 -7.08 (m, 2H), 6.61 (d, 1 H, J = 3.5 Hz), 6.56 (dd, 1 H, J = 9.4, 2.9 Hz), 3.76 (br s, 2H), 3.58 (s, 3H), 2.58 (s, 3H), 1 .90 (s, 3H). UPLC/MS (3 min) retention time 1 .87 min. LRMS: m/z 335 (M+1 ).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 824-51-1, 6-Methyl-1H-pyrrolo[2,3-b]pyridine.

Reference:
Patent; ALMIRALL, S.A.; VIDAL JUAN, Bernat; ALONSO DIEZ, Juan Antonio; BUIL ALBERO, Maria Antonia; EASTWOOD, Paul Robert; ESTEVE TRIAS, Cristina; LOZOYA TORIBIO, Maria Estrella; ROBERTS, Richard Spurring; VIDAL GISPERT, Laura; GONZALEZ RODRIGUEZ, Jacob; MIR CEPEDA, Marta; WO2013/10880; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 824-51-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 824-51-1, name is 6-Methyl-1H-pyrrolo[2,3-b]pyridine. This compound has unique chemical properties. The synthetic route is as follows.

PREPARATION 131 1 -(2-((1 ,4-Dimethyl-1 H-pyrazol-5-yl)methyl)-4-fluorophenyl)-6-methyl-1 H- pyrrolo[2,3-b]pyridine The title compound of Preparation 58 (0.150 g, 1 .13 mmol), potassium phosphate (0.48 g, 2.27 mmol) and the title compound of Preparation 130 (0.337 g, 1 .19 mmol) were suspended in 3 ml 1 ,4-dioxane in a Schlenk vessel and the mixture was subjected to three vacuum-argon cycles. Copper(l) iodide (44 mg, 0.23 mmol) and trans-N1 ,N2-dimethylcyclohexane-1 ,2-diamine (0.072 ml, 0.46 mmol) were added and the mixture was submitted to three further vacuum-argon cycles. The reaction vessel was sealed and the mixture was stirred at 130 C for 72 h. Further copper(l) iodide (22 mg, 0.12 mmol) and trans-N1 ,N2-dimethylcyclohexane-1 ,2-diamine (0.036 ml, 0.23 mmol) were added and the kixture was stirred at 130 C for 48 h. The mixture was allowed to cool to room temperature, diluted with ethyl acetate and filtered through Celite. The filtrate was evaporated under reduced pressure and the residue was purified by reverse-phase chromatography using the Isolera Purification System to give 140 mg (0.42 mmol, 37%) of the title compound as an oil. Purity 98%. 1 H N MR (300 MHz, CHLOROFORM-d) delta ppm 7.88 (d, 1 H, J = 8.2 Hz), 7.28-7.33 (m, 2H), 7.16 (d, 1 H, J = 3.5 Hz), 7.01 -7.08 (m, 2H), 6.61 (d, 1 H, J = 3.5 Hz), 6.56 (dd, 1 H, J = 9.4, 2.9 Hz), 3.76 (br s, 2H), 3.58 (s, 3H), 2.58 (s, 3H), 1 .90 (s, 3H). UPLC/MS (3 min) retention time 1 .87 min. LRMS: m/z 335 (M+1 ).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 824-51-1, 6-Methyl-1H-pyrrolo[2,3-b]pyridine.

Reference:
Patent; ALMIRALL, S.A.; VIDAL JUAN, Bernat; ALONSO DIEZ, Juan Antonio; BUIL ALBERO, Maria Antonia; EASTWOOD, Paul Robert; ESTEVE TRIAS, Cristina; LOZOYA TORIBIO, Maria Estrella; ROBERTS, Richard Spurring; VIDAL GISPERT, Laura; GONZALEZ RODRIGUEZ, Jacob; MIR CEPEDA, Marta; WO2013/10880; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 824-51-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 824-51-1, name is 6-Methyl-1H-pyrrolo[2,3-b]pyridine. A new synthetic method of this compound is introduced below.

A solution of 6-methyl-1 H-pyrrolo[2,3-b]pyridine (1.07g, 8.1 mmol) in ethyl acetate (37ml_) at 0C was treated with mCPBA (2.1 g, 12.2mmol) then stirred at 0C for 40 mins. mCPBA (0.21g, 1.2mmol) was added at 0C then left to warm to r.t and stirred overnight. Saturated aqueous sodium bicarbonate was added and the organic layer was separated. The aqueous was extracted with ethyl acetate, the combined organic phase was washed with saturated sodium bicarbonate, brine then dried (Na2S04) and concentrated in vacuo. The aqueous layers were combined and extracted with 2-methyltetrahydrofuran and the combined extracts were dried (Na2S04) and concentrated in vacuo. The two crude products were dissolved in hot methanol, combined, preadsorbed onto diatomaceous earth and purified by FCC eluting with 0-10% MeOH / DCM to afford the title compound as a pale orange solid (0.57g, 48%) LCMS (Method 3): Rt 0.74 min, m/z 149.1 [MH+].

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,824-51-1, its application will become more common.

Reference:
Patent; THE UNIVERSITY OF NOTTINGHAM; BROOK, David; HAYES, Chris; BENNETT, Nicholas; PALFRAMAN, Matthew; CRAMP, Sue; BULL, Richard; BODNARCHUK, Michael; (262 pag.)WO2019/58132; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 824-51-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 824-51-1, name is 6-Methyl-1H-pyrrolo[2,3-b]pyridine. A new synthetic method of this compound is introduced below.

A solution of 6-methyl-1 H-pyrrolo[2,3-b]pyridine (1.07g, 8.1 mmol) in ethyl acetate (37ml_) at 0C was treated with mCPBA (2.1 g, 12.2mmol) then stirred at 0C for 40 mins. mCPBA (0.21g, 1.2mmol) was added at 0C then left to warm to r.t and stirred overnight. Saturated aqueous sodium bicarbonate was added and the organic layer was separated. The aqueous was extracted with ethyl acetate, the combined organic phase was washed with saturated sodium bicarbonate, brine then dried (Na2S04) and concentrated in vacuo. The aqueous layers were combined and extracted with 2-methyltetrahydrofuran and the combined extracts were dried (Na2S04) and concentrated in vacuo. The two crude products were dissolved in hot methanol, combined, preadsorbed onto diatomaceous earth and purified by FCC eluting with 0-10% MeOH / DCM to afford the title compound as a pale orange solid (0.57g, 48%) LCMS (Method 3): Rt 0.74 min, m/z 149.1 [MH+].

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,824-51-1, its application will become more common.

Reference:
Patent; THE UNIVERSITY OF NOTTINGHAM; BROOK, David; HAYES, Chris; BENNETT, Nicholas; PALFRAMAN, Matthew; CRAMP, Sue; BULL, Richard; BODNARCHUK, Michael; (262 pag.)WO2019/58132; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 824-51-1, name is 6-Methyl-1H-pyrrolo[2,3-b]pyridine, the common compound, a new synthetic route is introduced below. Quality Control of 6-Methyl-1H-pyrrolo[2,3-b]pyridine

Azaindole 98 (55 mg, 0.42 mmol) was dissolved in 2 ml anhydrous dimethylformamide under nitrogen. Sodium hydride (60% dispersion in oil, 22 mg, 0.54 mmol) was added and the mixture was stirred for 45 min at room temperature. Bromide 10c (180 mg, 0.50 mmol) dissolved in 2 ml anhydrous dimethylformamide was added and the mixture was stirred for 3 h. The mixture was poured over ice-water and was extracted three times with ether. The combined organics were dried over anhydrous magnesium sulphate, filtered and evaporated under reduced pressure to give crude 109 (170 mg) as a yellow oil. Used as such without further purification. Purity 90%. NMR spectrum not recorded. UPLC/MS (3 min) retention time 1.97 min. LRMS: m/z 411 (M+1).

The synthetic route of 824-51-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Buil, Maria Antonia; Calbet, Marta; Castillo, Marcos; Castro, Jordi; Esteve, Cristina; Ferrer, Manel; Forns, Pilar; Gonzalez, Jacob; Lopez, Sara; Roberts, Richard S.; Sevilla, Sara; Vidal, Bernat; Vidal, Laura; Vilaseca, Pere; European Journal of Medicinal Chemistry; vol. 113; (2016); p. 102 – 133;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem