Category: 82523-07-7

Synthetic Route of 82523-07-7, Adding some certain compound to certain chemical reactions, such as: 82523-07-7, name is Methyl 3H-imidazo[4,5-c]pyridine-6-carboxylate,molecular formula is C8H7N3O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 82523-07-7.

Cooling in the ice bath,5g (28.22mmol) of 3H-imidazo[4,5-c]pyridine-6-carboxylate40mL NaOH aqueous solution (2M) dissolved,After 4 h of reaction, the reaction mixture was adjusted to pH 7 with dilute hydrochloric acid (2M).Allow to stand and allow the solid to be analyzed. Filter, filter and wash with distilled water, dry,Yield 1.757 g (38%) of the title compound.It is a pale yellow solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 82523-07-7, Methyl 3H-imidazo[4,5-c]pyridine-6-carboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Capital University of Medical Sciences; Zhao Ming; Peng Shiqi; Wang Yuji; Wu Jianhui; Gui Lin; Wang Yongjian; (13 pag.)CN108976225; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 82523-07-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.82523-07-7, name is Methyl 3H-imidazo[4,5-c]pyridine-6-carboxylate, molecular formula is C8H7N3O2, molecular weight is 177.16, as common compound, the synthetic route is as follows.

5 g (28.22 mmol) of 3H-imidazo[4,5-c]pyridine-6-carboxylic acid methyl ester was dissolved in 40 mL of NaOH aqueous solution (2M) under ice-cooling.After 4 h of reaction, the reaction mixture was adjusted to pH 7 with dilute hydrochloric acid (2M). Allow to stand and allow the solid to be analyzed. Filter, filter and wash with distilled water, dry, yield 1.757 g (38%) of the title compound. It is a pale yellow solid.

The chemical industry reduces the impact on the environment during synthesis 82523-07-7, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Capital University of Medical Sciences; Zhao Ming; Peng Shiqi; Wang Yuji; Wu Jianhui; Gui Lin; Wang Yongjian; (12 pag.)CN108976226; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 82523-07-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.82523-07-7, name is Methyl 3H-imidazo[4,5-c]pyridine-6-carboxylate, molecular formula is C8H7N3O2, molecular weight is 177.16, as common compound, the synthetic route is as follows.

5 g (28.22 mmol) of 3H-imidazo[4,5-c]pyridine-6-carboxylic acid methyl ester was dissolved in 40 mL of NaOH aqueous solution (2M) under ice-cooling.After 4 h of reaction, the reaction mixture was adjusted to pH 7 with dilute hydrochloric acid (2M). Allow to stand and allow the solid to be analyzed. Filter, filter and wash with distilled water, dry, yield 1.757 g (38%) of the title compound. It is a pale yellow solid.

The chemical industry reduces the impact on the environment during synthesis 82523-07-7, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Capital University of Medical Sciences; Zhao Ming; Peng Shiqi; Wang Yuji; Wu Jianhui; Gui Lin; Wang Yongjian; (12 pag.)CN108976226; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 82523-07-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.82523-07-7, name is Methyl 3H-imidazo[4,5-c]pyridine-6-carboxylate, molecular formula is C8H7N3O2, molecular weight is 177.16, as common compound, the synthetic route is as follows.

Methyl 3H-imidazo[4,5-c]pyridin-6-carboxylate (44 mg, 0.25 mmol) was dissolved in N,N-dimethylformamide (2 mL) to which potassium carbonate (69 mg, 0.50 mmol) was added and then stirred at room temperature for 10 minutes. Then, benzyl (2R,3S)-2-(3-bromo-2-oxopropyl)-3-(tert-butyldimethylsilyloxy)piperidin-1-carboxylate (120 mg, 0.25 mmol) was added thereto and stirred at room temperature for 3 hours. When the reaction is completed, the solvent was removed, and the resulting mixture was diluted with ethyl acetate and then washed with saturated sodium chloride solution. The organic layer was collected, dried over magnesium sulfate, filtered and concentrated under reduced pressure, and then purified by column chromatography (dichloromethane:methanol=10:1), thereby obtaining the title compound (110 mg, yield: 79%).

The chemical industry reduces the impact on the environment during synthesis 82523-07-7, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Daewoong Pharmaceutical., Ltd.; Park, Joon Seok; Yoon, Youn Jung; Cho, Min Jae; Lee, Ho Bin; Yoo, Ja Kyung; Bong, Yong Lee; (47 pag.)US2017/88551; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 82523-07-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.82523-07-7, name is Methyl 3H-imidazo[4,5-c]pyridine-6-carboxylate, molecular formula is C8H7N3O2, molecular weight is 177.16, as common compound, the synthetic route is as follows.

Methyl 3H-imidazo[4,5-c]pyridin-6-carboxylate (44 mg, 0.25 mmol) was dissolved in N,N-dimethylformamide (2 mL) to which potassium carbonate (69 mg, 0.50 mmol) was added and then stirred at room temperature for 10 minutes. Then, benzyl (2R,3S)-2-(3-bromo-2-oxopropyl)-3-(tert-butyldimethylsilyloxy)piperidin-1-carboxylate (120 mg, 0.25 mmol) was added thereto and stirred at room temperature for 3 hours. When the reaction is completed, the solvent was removed, and the resulting mixture was diluted with ethyl acetate and then washed with saturated sodium chloride solution. The organic layer was collected, dried over magnesium sulfate, filtered and concentrated under reduced pressure, and then purified by column chromatography (dichloromethane:methanol=10:1), thereby obtaining the title compound (110 mg, yield: 79%).

The chemical industry reduces the impact on the environment during synthesis 82523-07-7, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Daewoong Pharmaceutical., Ltd.; Park, Joon Seok; Yoon, Youn Jung; Cho, Min Jae; Lee, Ho Bin; Yoo, Ja Kyung; Bong, Yong Lee; (47 pag.)US2017/88551; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem