Category: 82671-02-1

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 82671-02-1, name is 2,6-Dichloro-5-fluoronicotinonitrile. A new synthetic method of this compound is introduced below., Computed Properties of C6HCl2FN2

Preparation 46; C- .-methylamine; Add to a Parr Bottle 2,6 dichloro-3-cyano-5-fluoropyridine (5g, 26.18mmol), ethanol (50ml), concentrated hydrochloric acid (4. 3ml) and 10% Pd-C (0. 5g). Place on a Parr Shaker Appartus under 36 psig hydrogen for 6 hours at ambient temperature. Add potassium acetate (10.28g, 104. 72mmol) and continue under 48 psig hydrogen overnight at ambient temperature. Filter the reaction over Celite and concentrate the filtrate under vacuum to a residue. Add to the residue THF (100ml). Filter the solid, and concentrate the filtrate under vacuum to give (5-Fluoro-pyridin-3-yl)-methylamine as a clear oil (6g). ‘H NMR (DMSO): 8.6 (d, 2H), 8.0 (d, 1H), 4.2 (s, 2H). MS (ES+) = 127.5

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 82671-02-1, 2,6-Dichloro-5-fluoronicotinonitrile.

Reference:
Patent; ELI LILLY AND COMPANY; WO2005/66126; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.82671-02-1, name is 2,6-Dichloro-5-fluoronicotinonitrile, molecular formula is C6HCl2FN2, molecular weight is 190.99, as common compound, the synthetic route is as follows.Recommanded Product: 2,6-Dichloro-5-fluoronicotinonitrile

Weigh 2,6-dichloro-5-fluoro-pyridine-3-carbonitrile (24.8 g, 130 mmol)Concentrated sulfuric acid (125 mL) was added to a 500 ml flask, and the mixture was heated to 62 C for 1 hour.After cooling to room temperature, the reaction solution was poured into ice water (800 mL) and ethyl acetate (300 mL×4).The organic phase was washed successively with water (100 mL), saturated sodium bicarbonate (100 mL) and brine (50 mL).Dry over anhydrous sodium sulfate.Filtered, the filtrate was dried,A pale yellow solid (27.0 g, 99.5%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,82671-02-1, 2,6-Dichloro-5-fluoronicotinonitrile, and friends who are interested can also refer to it.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Wang Xiaojun; Zuo Yinglin; Yu Chuan; Yang Chuanwen; Wang Jiancheng; Li Jing; Cao Shengtian; Wu Fangyuan; Zhang Yingjun; S ·geerdeman; (79 pag.)CN108690016; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem