Category: 82671-06-5

Synthetic Route of 82671-06-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 82671-06-5 as follows.

In a round-necked flask 2,6-dichloro-5-fluoro-nicotinic acid (20.0g, 95.2mmol), sodium methoxide (11.3g, 210mmol) and anhydrous methanol (with 260 mL of), the reaction was refluxed for 4 hours, cooled to at room temperature, was added 200mL of water, acidified with concentrated hydrochloric pH = 1, then extracted with ethyl acetate, dried over anhydrous Na2SO4Dried, the solvent was spin-product 19.0g, a yield of 97.4%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,82671-06-5, its application will become more common.

Reference:
Patent; Shandong Xuanzhu Pharmaceutical Technology co., LTD; WU, YONG QIAN; WANG, AI CHEN; (35 pag.)CN102887895; (2016); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 82671-06-5, Adding some certain compound to certain chemical reactions, such as: 82671-06-5, name is 2,6-Dichloro-5-fluoropyridine-3-carboxylic acid,molecular formula is C6H2Cl2FNO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 82671-06-5.

To a round-bottomed flask under a N2 atmosphere were added degassed DMF (270 mL), Pd(OAc)2 (0.05 eq, 2.7 g, 11.9 mmol), PPh3 (0.1 eq, 6.2 g, 23.8 mmol), and degassed Et3N (6 eq, 200 mL, 1428.6 mmol). The mixture was stirred for 20 minutes, HCOOH (3 eq, 28 mL, 714.3 mmol) was then added. 5 minutes later, 2,6-dichloro-5-fluoronicotinic acid (50 g, 238.1 mmol) was added. The mixture was stirred at 50 C. The reaction was followed by analysis (1H NMR) of a worked-up aliquot. When all starting material was consumed (24 h), the mixture was cooled to 0 C. and water (500 mL) was added. After 20 minutes, The mixture was filtered through a pad of Celite that was rinsed with water. The mixture was basified to pH 9 with 30% aq. NaOH and washed with EtOAc (2*). HCl (12 N) was added slowly to pH 1 and the solution was saturated with NaCl. The mixture was extracted with EtOAc (3*). The combined organic extracts were washed with brine, dried (Na2SO4), and concentrated under reduced pressure to give 37 g (88%) of a beige solid used in the next step without further purification. 1H NMR (DMSO-d6, 300 MHz): delta 8.16 (dd, 1H); 8.58 (d, 1H).

According to the analysis of related databases, 82671-06-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; US2011/20377; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 82671-06-5 , The common heterocyclic compound, 82671-06-5, name is 2,6-Dichloro-5-fluoropyridine-3-carboxylic acid, molecular formula is C6H2Cl2FNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Intermediate[00144] The overall synthetic scheme for the synthesis of5-fluoro-lH-pyrazolo [3, 4-b] pyridin-3-amine 5 is depicted below.1 6 3Reagents and conditions: i. Pd (OAc) 2, PPh3, Et3N, H2CO2; ii. 1) (COCl)2, CH2Cl2, cat. DMF; 2) NH3 (g) , dioxane, iii. TFAA, Et3N, CH2Cl2, 0C; iv. H2NNH2. H2O, n-butanol, reflux2-Chloro-5-fluoronicotinic acid (6)[00145] To a round-bottomed flask under a N2 atmosphere were added degassed DMF (270 ?iL) , Pd(OAc)2 (0.05 eq, 2.7 g, 11.9 mmol) , PPh3 (0.1 eq, 6.2 g, 23.8 mmol) , and degassed Et3N (6 eq, 200 mL, 1428.6 mmol) . The mixture was stirred for 20 minutes, HCOOH (3 eq, 28 mL, 714.3 mmol) was then added. 5 minutes later, 2, 6-dichloro-5-fluoronicotinic acid (50 g, 238.1 mmol) was added. The mixture was stirred at 500C. The reaction was followed by analysis (IH NMR) of a worked- up aliquot. When all starting material was consumed (24 h) , the mixture was cooled to 00C and water (500 mL) was added. After 20 minutes, The mixture was filtered through a pad of Celite that was rinsed with water. The mixture was basified to pH 9 with 30% aq. NaOH and washed with EtOAc (2x) . HCl(12 N) was added slowly to pH 1 and the solution was saturated with NaCl. The mixture was extracted with EtOAc (3x) . The combined organic extracts were washed with brine, dried (Na2SO4) , and concentrated under reduced pressure to give 37 g (88%) of a beige solid used in the next step without further purification. 1H NMR (DMSO-de, 300 MHz): delta 8.16 (dd, IH); 8.58 (d, IH).

The synthetic route of 82671-06-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; WO2008/112646; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 82671-06-5, 2,6-Dichloro-5-fluoropyridine-3-carboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 82671-06-5, blongs to pyridine-derivatives compound. Quality Control of 2,6-Dichloro-5-fluoropyridine-3-carboxylic acid

S1, 43 g of 2,6-dichloro-5-fluoronicotinic acid was added to 150 ml of toluene, then 86 ml of thionyl chloride was added, and the mixture was heated under reflux for 3 hours, and then toluene and thionyl chloride were evaporated under reduced pressure. Yellow liquid 2,6-dichloro-3-fluoronicotinoyl chloride;

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,82671-06-5, its application will become more common.

Reference:
Patent; Shanghai Kaluo Chemical Co., Ltd.; Tan Juncheng; Zhang Yinlan; (11 pag.)CN109678793; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 82671-06-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 82671-06-5, name is 2,6-Dichloro-5-fluoropyridine-3-carboxylic acid. This compound has unique chemical properties. The synthetic route is as follows.

[0253] A mixture of 2,6-dichloro-5-fluoronicotinic acid (1.26 g, 6.0 mmol), 3-fluorophenethyl amine (1.25 ml_, 9.0 mmol), DIEA (3.14 ml_, 18 mmol) and MeCN (6 ml.) was refluxed for 48 hrs and concentrated. The residue was dissolved in EtOAc (120 ml_) and washed with saturated citric acid, water, brine, dried and concentrated. The organic layers were combined, dried (MgSO4) and concentrated. The residue was purified on RP-HPLC using a mixture of acetonitrile and H2O to give 6-chloro-5-fluoro-2-(3-fluorophenethylamino)nicotinic acid as a solid (920 mg, 49%). LRMS (M+H+) m/z 313.0.

According to the analysis of related databases, 82671-06-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CYTOKINETICS, INCORPORATED; WO2008/16643; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 82671-06-5, 2,6-Dichloro-5-fluoropyridine-3-carboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C6H2Cl2FNO2, blongs to pyridine-derivatives compound. Formula: C6H2Cl2FNO2

CDI (35.6 g, 220 mmol) was added portionwise to a solution of C1 (42 g, 200 mmol) in THF (400 mL).The mixture was stirred for 5 min, protected with Ar, heated to 50 C, and reacted for 1 h.After LC-MS monitoring, the starting material disappeared, and the reaction mixture was diluted with toluene (100 mL) and concentrated to half of the original volume.The resulting mixture was cooled to 0 C and ammonium hydroxide (55 mL, 400 mmol) was slowly added.The reaction was carried out for 10 min at room temperature, diluted with EA (200 mL) and washed with water (100 mL*3).The organic layer was dried over anhydrous Na 2 SO 4 and dried. PE/EA (10/1, 200 mL) beaten, filtered,The remaining mother liquor was concentrated to half of the initial volume, cooled to 0 C, and the solid was again precipitated and filtered.The two crops were combined to give a pale-yellow solid product 74-1 (22.10 g, yield 53%).The primary product was used in the next reaction without purification.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,82671-06-5, 2,6-Dichloro-5-fluoropyridine-3-carboxylic acid, and friends who are interested can also refer to it.

Reference:
Patent; Weijing Biological Pharmaceutical (Shanghai) Co., Ltd.; Fan Houxing; Xie Yuli; (72 pag.)CN110256421; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 82671-06-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 82671-06-5 as follows.

Example 16A (^-Sjdelta-Difluoro^-hydroxy^^i^Kfl.SloxathioIoS^-clpyridin-theta- ylmethyl)amino]-l-piperidinyl}methyI)-4,5-dihydro-7H-pyrrolo[3,2,l-^]-l?5- naphthyridin-7-one dihydrochloride(a) 2-Chloro-5-fluoro-6-(methyloxy)-3-pyridinecarboxylic acidA solution of 2,6-dichloro-5-fluoro-3-pyridinecarboxylic acid (51.12g, 243 mmol) in methanol (400 ml) was treated with sodium methoxide in methanol (25% w/v, 100 ml, 535 mmol) and the mixture heated to reflux for 4 hours. The cooled mixture was treated with water (400 ml) and acidified to pH2 with aqueous hydrochloric acid (2M) then concentrated to ca 400 ml. Filtration, washing with water and drying in vacuo over P2O5 for 18h afforded the product as a white solid (32.65g, 65%). MS (+ve ion electrospray) m/z 208 (MH+).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,82671-06-5, its application will become more common.

Reference:
Patent; GLAXO GROUP LIMITED; WO2007/71936; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 82671-06-5, name is 2,6-Dichloro-5-fluoropyridine-3-carboxylic acid, molecular formula is C6H2Cl2FNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. SDS of cas: 82671-06-5

To a round-bottomed flask under a N2 atmosphere were added degassed DMF (270 ?iL) , Pd(OAc)2 (0.05 eq, 2.7 g, 11.9 mmol) , PPh3 (0.1 eq, 6.2 g, 23.8 mmol) , and degassed Et3N (6 eq, 200 mL, 1428.6 mmol) . The mixture was stirred for 20 minutes, HCOOH (3 eq, 28 mL, 714.3 mmol) was then added. 5 minutes later, 2, 6-dichloro-5-fluoronicotinic acid (50 g, 238.1 mmol) was added. The mixture was stirred at 500C. The reaction was followed by analysis (IH NMR) of a worked- up aliquot. When all starting material was consumed (24 h) , the mixture was cooled to 00C and water (500 mL) was added. After 20 minutes, The mixture was filtered through a pad of Celite that was rinsed with water. The mixture was basified to pH 9 with 30% aq. NaOH and washed with EtOAc (2x) . HCl(12 N) was added slowly to pH 1 and the solution was saturated with NaCl. The mixture was extracted with EtOAc(3x) . The combined organic extracts were washed with brine, dried (Na2SO4) , and concentrated under reduced pressure to give 37 g (88%) of a beige solid used in the next step without further purification.1H NMR (DMSO-de, 300 MHz): delta 8.16 (dd, IH); 8.58 (d, IH).

With the rapid development of chemical substances, we look forward to future research findings about 82671-06-5.

Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; WO2008/112642; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem