Category: 829-45-8

Adding a certain compound to certain chemical reactions, such as: 829-45-8, Methyl 3-(4-Pyridyl)-3-oxopropanoate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C9H9NO3, blongs to pyridine-derivatives compound. HPLC of Formula: C9H9NO3

General procedure: A solution of the amidine 6 (1.1 equiv, 276 mg, 1.23 mmol) and the beta-ketoester 8a (1 equiv, 200 mg, 1.12 mmol) in nBuOH (3 mL) was stirred at 110 C for 18 h. During this time a solid precipitate formed. After cooling to room temperature, the solid was filtered off and air-dried to provide 9a (190 mg, 48%) as a pale yellow solid;

At the same time, in my other blogs, there are other synthetic methods of this type of compound,829-45-8, Methyl 3-(4-Pyridyl)-3-oxopropanoate, and friends who are interested can also refer to it.

Reference:
Article; Large, Jonathan M.; Torr, Jane E.; Raynaud, Florence I.; Clarke, Paul A.; Hayes, Angela; Stefano, Francesca Di; Urban, Frederique; Shuttleworth, Stephen J.; Saghir, Nahid; Sheldrake, Peter; Workman, Paul; McDonald, Edward; Bioorganic and Medicinal Chemistry; vol. 19; 2; (2011); p. 836 – 851;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 829-45-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 829-45-8, name is Methyl 3-(4-Pyridyl)-3-oxopropanoate. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: A mixture of aldehyde 1a-1i or 5a-5k (4 mmol), malononitrile (4 mmol), dimethyl 3-oxo-1,5-pentanedioate or methyl/ethyl 3-oxo-3-arylpropanoate (4 mmol), respectively, and DIPEA (6 mmol) in EtOH (20 mL) was stirred at room temperature. The reaction progress was monitored by TLC. After completion of the reaction, the solid material that formed was collected by filtration and recrystallized from EtOH to obtain the desired product.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 829-45-8, Methyl 3-(4-Pyridyl)-3-oxopropanoate.

Reference:
Article; Li, Jun; Li, Jie; Hu, Shi-yu; Chen, Ye; Liu, Ju; Russian Journal of Organic Chemistry; vol. 55; 11; (2019); p. 1791 – 1799; Zh. Org. Khim.;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem