Category: 832735-60-1

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 832735-60-1, name is 7-Bromo-[1,2,4]triazolo[4,3-a]pyridine. This compound has unique chemical properties. The synthetic route is as follows. Formula: C6H4BrN3

To a suspension of 7-bromo-[l,2,4]triazolo[4,3-a]pyridine (930.9 mg, 4.70 mmol) and diphenylmethanimine (1.70 g, 9.38 mmol) in toluene (40 mL) were added Pd2(dba)3 (217.7 mg, 0.24 mmol), BINAP (293.4 mg, 0.45 mmol) and t-BuONa (908.4 mg, 9.45 mmol). The reaction mixture was stirred at 100 C overnight and quenched with water (50 mL), and the resulting mixture was extracted with EtOAc (100 mL x 3). The combined organic phases were washed with brine (100 mL), dried over anhydrous Na2S04, filtered and concentrated in vacuo. The residue was purified by silica gel column chromatography (MeOH/DCM (v/v) = 1/20) to give the title compound as a brown solid (1.66 g, yield 46.3%).MS (ESI, pos. ion) m/z: 299.2 [M+H]+.

With the rapid development of chemical substances, we look forward to future research findings about 832735-60-1.

Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; CALITOR SCIENCES, LLC; XI, Ning; LI, Minxiong; PENG, Ju; LI, Xiaobo; ZHANG, Tao; HU, Haiyang; CHEN, Wuhong; BAI, Changlin; KE, Donghua; CHEN, Peng; (281 pag.)WO2019/99311; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 832735-60-1, name is 7-Bromo-[1,2,4]triazolo[4,3-a]pyridine. This compound has unique chemical properties. The synthetic route is as follows. Formula: C6H4BrN3

To a suspension of 7-bromo-[l,2,4]triazolo[4,3-a]pyridine (930.9 mg, 4.70 mmol) and diphenylmethanimine (1.70 g, 9.38 mmol) in toluene (40 mL) were added Pd2(dba)3 (217.7 mg, 0.24 mmol), BINAP (293.4 mg, 0.45 mmol) and t-BuONa (908.4 mg, 9.45 mmol). The reaction mixture was stirred at 100 C overnight and quenched with water (50 mL), and the resulting mixture was extracted with EtOAc (100 mL x 3). The combined organic phases were washed with brine (100 mL), dried over anhydrous Na2S04, filtered and concentrated in vacuo. The residue was purified by silica gel column chromatography (MeOH/DCM (v/v) = 1/20) to give the title compound as a brown solid (1.66 g, yield 46.3%).MS (ESI, pos. ion) m/z: 299.2 [M+H]+.

With the rapid development of chemical substances, we look forward to future research findings about 832735-60-1.

Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; CALITOR SCIENCES, LLC; XI, Ning; LI, Minxiong; PENG, Ju; LI, Xiaobo; ZHANG, Tao; HU, Haiyang; CHEN, Wuhong; BAI, Changlin; KE, Donghua; CHEN, Peng; (281 pag.)WO2019/99311; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 832735-60-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 832735-60-1 as follows.

Example 444 (1538) N-tert-Butyl-3?-fluoro-4?[1,2,4]triazolo[4,3-a]pyridin-7-ylbiphenyl-2-sulfonamide (1539) To a 20 mL vial were added N-(tert-butyl)-3?-fluoro-4?-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-[1,1?-biphenyl]-2-sulfonamide (45 mg, 0.10 mmol), 7-bromo-[1,2,4]triazolo[4,3-a]pyridine (21 mg, 0.10 mmol) K2CO3 (29 mg, 0.21 mmol), Pd(dppf)Cl2.CH2Cl2 (4 mg, 0.005 mmol), and a stir bar. The vial was sealed with a teflon lined cap and the vial sparged with N2. The vial was then charged with freshly sparged DMSO (2 mL) and stirred for 16 hours at 80 Celsius. The reaction mixture was then cooled to rt, filtered, and purified by HPLC to give the title compound (30 mg, 53%). MS (ESI): mass calcd. for C22H21FN4O2S, 424.14; m/z found, 425.1 [M+H]+. 1H NMR (400 MHz, CD3OD) delta 9.40 (s, 1H), 8.79 (s, 1H), 8.20-8.11 (m, 2H), 7.77 (m, 1H), 7.70-7.57 (m, 3H), 7.47-7.38 (m, 3H), 1.10 (5, 9H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,832735-60-1, its application will become more common.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; Bacani, Genesis M.; Eccles, Wendy; Fitzgerald, Anne E.; Goldberg, Steven D.; Hack, Michael D.; Hawryluk, Natalie A.; Jones, William M.; Keith, John M.; Krawczuk, Paul; Lebsack, Alec D.; Lee-Dutra, Alice; Liu, Jing; McClure, Kelly J.; Meduna, Steven P.; Pippel, Daniel J.; Rosen, Mark D.; Sales, Zachary S.; US2015/259357; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 832735-60-1 , The common heterocyclic compound, 832735-60-1, name is 7-Bromo-[1,2,4]triazolo[4,3-a]pyridine, molecular formula is C6H4BrN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To 7-bromo-[1,2,4]triazolo[4,3-a]pyridine (930.9 mg, 4.70 mmol)And benzophenone imine (1.70g, 9.38mmol)Toluene (40 mL) suspension was addedPd2(dba)3 (217.7 mg, 0.24 mmol), BINAP (293.4 mg, 0.45 mmol)And t-BuONa (908.4 mg, 9.45 mmol).The reaction system was stirred at 100 C overnight.After the reaction,The reaction was quenched by the addition of water (50 mL).The resulting mixture was extracted with EtOAc (100 mL×3).The combined organic phases were washed with brine (100 mL).Dry over anhydrous sodium sulfate,Filter and concentrate under reduced pressure.The residue obtained is purified by silica gel column chromatography (MeOH/DCM (v/v) = 1 / 20).The title compound was obtained as a brown solid (1.66 g, yield 46.3%).

The synthetic route of 832735-60-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jiatuo Sciences Corporation; Xi Ning; Li Minxiong; Peng Ju; Li Xiaobo; Zhang Tao; Hu Haiyang; Chen Wuhong; Bai Changlin; Ke Donghua; Chen Peng; (217 pag.)CN109776522; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem