Category: 84199-61-1

Extracurricular laboratory: Synthetic route of 3-Acetyl-2-bromopyridine

The synthetic route of 84199-61-1 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 84199-61-1, 3-Acetyl-2-bromopyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C7H6BrNO, blongs to pyridine-derivatives compound. COA of Formula: C7H6BrNO

General procedure: An solution of indicated quantity of DAST in dry CH2Cl2 was added dropwise to a solution of 14 (26.9mmol) in dry CH2Cl2 (50mL) at 0C. The reaction mixture was warmed to rt and stirred for indicated period of time. The resulting mixture was poured into H2O (50mL), sat. aq NaHCO3 was added to pH=8, and organic phase was separated. The aqueous layer was extracted with CH2Cl2 (3×50mL), the combined organic layers were dried over Na2SO4, and then evaporated under reduced pressure.

The synthetic route of 84199-61-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Subota, Andrii I.; Ryabukhin, Sergey V.; Gorlova, Alina O.; Grygorenko, Oleksandr O.; Volochnyuk, Dmitriy M.; Journal of Fluorine Chemistry; vol. 224; (2019); p. 61 – 66;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Analyzing the synthesis route of 3-Acetyl-2-bromopyridine

The synthetic route of 84199-61-1 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 84199-61-1, 3-Acetyl-2-bromopyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C7H6BrNO, blongs to pyridine-derivatives compound. Formula: C7H6BrNO

Synthesis of 7-phenylquinolin-5-ol (6.1) for Example 1[0271] 3-Acetyl-2-bromopyridine, 56 muL phenylacetylene, 170 muL DIPEA, 22.5 mg triphenylphosphinpalladium(II) chlorid, 3 mg Cu(I)I were suspended in 1 mL DMF under argon atmosphere and stirred for 16 h at 25 C. The mixture was diluted with DCM and extracted with diluted aq. NH3 and brine. The organic phase was concentrated and the mixture separated via flash chromatography (10 g SiO2, cyclohexane?cyclohexane/ethylacetate 70:30) to yield 40 mg 1-(2-(phenylethynyl)pyridin-3-yl)ethanone as solid. Analysis: HPLC-MS: Rt=1.21 min (method E), M+H=222

The synthetic route of 84199-61-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; HOFFMANN, Matthias; BISCHOFF, Daniel; DAHMANN, Georg; KLICIC, Jasna; SCHAENZLE, Gerhard; WOLLIN, Stefan Ludwig Michael; CONVERS-REIGNIER, Serge Gaston; EAST, Stephen Peter; MARLIN, Frederic Jacques; McCARTHY, Clive; SCOTT, John; US2013/29949; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem