Category: 845306-04-9

Application of 845306-04-9, Adding some certain compound to certain chemical reactions, such as: 845306-04-9, name is 6-Chloro-N-methylpicolinamide,molecular formula is C7H7ClN2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 845306-04-9.

In a pressure tube, argon was bubbled through a suspension of 3,3-dimethyl-6-(2-methylpyrimidin-5-yl)indolin-2-one (50 mg, 197 muiotaetaomicron, Eq: 1, WO2014/202493 Al), 6-chloro- N-methylpicolinamide (40.4 mg, 237 muiotaetaomicron, Eq: 1.2) and cesium carbonate (83.6 mg, 257 muiotaetaomicron, Eq: 1.3) in dioxane (987 mu) for 5 minutes. Xantphos (22.8 mg, 39.5 muiotaetaomicron, Eq: 0.2) and tris(dibenzylideneacetone)dipalladium (0) (36.2 mg, 39.5 muiotaetaomicron, Eq: 0.2) were added and the reaction mixture was heated to 120 C for 1 day under argon. The residue was evaporated in vacuo and purified by chromatography on silica gel, followed by prep HPLC to afford the desired product as a light yellow solid (45 mg, 58 ). MS (m/z) = 388.2 [M + H]+.

According to the analysis of related databases, 845306-04-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; GAUFRETEAU, Delphine; KOLCZEWSKI, Sabine; PLANCHER, Jean-Marc; STOLL, Theodor; HALM, Remy; (85 pag.)WO2017/76852; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 845306-04-9, Adding some certain compound to certain chemical reactions, such as: 845306-04-9, name is 6-Chloro-N-methylpicolinamide,molecular formula is C7H7ClN2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 845306-04-9.

In a pressure tube, argon was bubbled through a suspension of 3,3-dimethyl-6-(2-methylpyrimidin-5-yl)indolin-2-one (50 mg, 197 muiotaetaomicron, Eq: 1, WO2014/202493 Al), 6-chloro- N-methylpicolinamide (40.4 mg, 237 muiotaetaomicron, Eq: 1.2) and cesium carbonate (83.6 mg, 257 muiotaetaomicron, Eq: 1.3) in dioxane (987 mu) for 5 minutes. Xantphos (22.8 mg, 39.5 muiotaetaomicron, Eq: 0.2) and tris(dibenzylideneacetone)dipalladium (0) (36.2 mg, 39.5 muiotaetaomicron, Eq: 0.2) were added and the reaction mixture was heated to 120 C for 1 day under argon. The residue was evaporated in vacuo and purified by chromatography on silica gel, followed by prep HPLC to afford the desired product as a light yellow solid (45 mg, 58 ). MS (m/z) = 388.2 [M + H]+.

According to the analysis of related databases, 845306-04-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; GAUFRETEAU, Delphine; KOLCZEWSKI, Sabine; PLANCHER, Jean-Marc; STOLL, Theodor; HALM, Remy; (85 pag.)WO2017/76852; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 845306-04-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.845306-04-9, name is 6-Chloro-N-methylpicolinamide, molecular formula is C7H7ClN2O, molecular weight is 170.5963, as common compound, the synthetic route is as follows.

A stirred solution of intermediate 2 (0.6g, 1.91 mmol) in dry 1,4-dioxane (10 mL), was added cesium carbonate (I.9g, 5.88 mmol) followed by 6-chloro-N-methylpicolinamide (0.25 g, 1.47 mmol, ABCR). Nitrogen was flushed into the solution for 20 mm and Pd(OAc)2 (0.016 g, 0.07 mmol) and 2-2?-bis (diphenylphosphino)-I-I?-binaphthyl (0.091g, 0.14 mmol) were added. The reaction mixture was stirred at 100 C for 12 h. The resulting reactionmixture was filtered through celite and evaporated under vacuum. Water (5 mL) was added and the mixture was extracted with EtOAc (5OmL). The organic layer was dried over anhydrous Na2SO4 and evaporated. The resulting crude product was purified by column chromatography ( brown solid). 1H NMR (400 MHz, DMSO-d6): 6 8.94-8.92 (m, 2H), 8.41 (d, J = 4.0 Hz, I H), 8.09 (d, J = 8.8 Hz, I H), 8.01 (5, 1 H), 7.94-7.94 (m, I H), 7.63 (t, J = 8.4 Hz, IH), 7.25-7.23 (m, IH), 6.94 (d, J = 8.4 Hz, IH), 3.79-3.77 (m, IH), 3.58-3.58 (m, 4H),2.77 (d, J = 4.80 Hz, 3H), 2.59-2.58 (m, 2H), 2.49-2.45 (m, 2H), 1.45 (d, J = 6.80 Hz, 3H). LCMS: (Method A) 377.2 (M +H), Rt. 2.14mm, 95.23% (Max). HPLC: (Method A) Rt. 2.07mm, 96.75% (Max).

Statistics shows that 845306-04-9 is playing an increasingly important role. we look forward to future research findings about 6-Chloro-N-methylpicolinamide.

Reference:
Patent; ASCENEURON S. A.; QUATTROPANI, Anna; KULKARNI, Santosh, S.; GIRI, Awadut, Gajendra; (280 pag.)WO2017/144633; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 845306-04-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 845306-04-9, name is 6-Chloro-N-methylpicolinamide. This compound has unique chemical properties. The synthetic route is as follows.

A stirred solution of Intermediate 2 (0.6g, 1.91 mmol) in dry 1 ,4-dioxane (10 mL), was added cesium carbonate (1.9g, 5.88 mmol) followed by 6-chloro-N-methylpicolinamide (0.25 g, 1.47 mmol, ABCR). Nitrogen was flushed into the solution for 20 min and Pd(OAc)2 (0.016 g, 0.07 mmol) and 2-2′-bis (diphenylphosphino)-1,1′-binaphthyl (0.091 g, 0.14 mmol) were added. The reaction mixture was stirred at 100 C for 12 h. The resulting reaction mixture was filtered through celite and evaporated under vacuum. Water (5 mL) was added and the mixture was extracted with EtOAc (50mL). The organic layer was dried over anhydrous Na2SO4 and evaporated. The resulting crude product was purified by column chromatography ( brown solid). 1H NMR (400 MHz, DMSO-d6): delta 8.94-8.92 (m, 2H), 8.41 (d, J = 4.0 Hz, 1 H), 8.09 (d, J = 8.8 Hz, 1 H), 8.01 (s, 1 H), 7.94-7.94 (m, 1 H), 7.63 (t, J = 8.4 Hz, 1 H), 7.25-7.23 (m, 1 H), 6.94 (d, J = 8.4 Hz, 1 H), 3.79-3.77 (m, 1 H), 3.58-3.58 (m, 4H), 2.77 (d, J = 4.80 Hz, 3H), 2.59-2.58 (m, 2H), 2.49-2.45 (m, 2H), 1.45 (d, J = 6.80 Hz, 3H). LCMS: (Method A) 377.2 (M +H), Rt. 2.14min, 95.23% (Max). HPLC: (Method A) Rt. 2.07min, 96.75% (Max).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 845306-04-9, 6-Chloro-N-methylpicolinamide.

Reference:
Patent; ASCENEURON S. A.; QUATTROPANI, Anna; KULKARNI, Santosh, S.; GIRI, Awadut Gajendra; (247 pag.)WO2017/144639; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 845306-04-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 845306-04-9, name is 6-Chloro-N-methylpicolinamide. This compound has unique chemical properties. The synthetic route is as follows.

A stirred solution of Intermediate 2 (0.6g, 1.91 mmol) in dry 1 ,4-dioxane (10 mL), was added cesium carbonate (1.9g, 5.88 mmol) followed by 6-chloro-N-methylpicolinamide (0.25 g, 1.47 mmol, ABCR). Nitrogen was flushed into the solution for 20 min and Pd(OAc)2 (0.016 g, 0.07 mmol) and 2-2′-bis (diphenylphosphino)-1,1′-binaphthyl (0.091 g, 0.14 mmol) were added. The reaction mixture was stirred at 100 C for 12 h. The resulting reaction mixture was filtered through celite and evaporated under vacuum. Water (5 mL) was added and the mixture was extracted with EtOAc (50mL). The organic layer was dried over anhydrous Na2SO4 and evaporated. The resulting crude product was purified by column chromatography ( brown solid). 1H NMR (400 MHz, DMSO-d6): delta 8.94-8.92 (m, 2H), 8.41 (d, J = 4.0 Hz, 1 H), 8.09 (d, J = 8.8 Hz, 1 H), 8.01 (s, 1 H), 7.94-7.94 (m, 1 H), 7.63 (t, J = 8.4 Hz, 1 H), 7.25-7.23 (m, 1 H), 6.94 (d, J = 8.4 Hz, 1 H), 3.79-3.77 (m, 1 H), 3.58-3.58 (m, 4H), 2.77 (d, J = 4.80 Hz, 3H), 2.59-2.58 (m, 2H), 2.49-2.45 (m, 2H), 1.45 (d, J = 6.80 Hz, 3H). LCMS: (Method A) 377.2 (M +H), Rt. 2.14min, 95.23% (Max). HPLC: (Method A) Rt. 2.07min, 96.75% (Max).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 845306-04-9, 6-Chloro-N-methylpicolinamide.

Reference:
Patent; ASCENEURON S. A.; QUATTROPANI, Anna; KULKARNI, Santosh, S.; GIRI, Awadut Gajendra; (247 pag.)WO2017/144639; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem