Category: 846021-26-9

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 846021-26-9, name is 2-Amino-6-methylnicotinic acid, molecular formula is C7H8N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. HPLC of Formula: C7H8N2O2

2-Amino-6-methyl nicotinic acid (3.04 g) was suspended in N,N-dimethylformamide (60 mE), and potassium carbonate (5.53 g) was added to the suspension, followed by stirring at 40 C. for 30 minutes. Solution (I) was dropwise added to the resulting suspension, followed by stirring with heating at 80 C. for 2 hours. The reaction solution was cooled to room temperature, and the N,N-dimethylformamide (50 mE, 71%) was removed by distillation under reduced pressure. Iced water (100 mE) was added to the residue, followed by stirring at room temperature for minutes. Precipitated crystals were collected by filtration and were dried to give 6.13 g (yield: 91%) of the target product (Compound 6 shown in Table 1). According to purity analysis by liquid chromatography, the purity of thus obtained target product was high, 98.5%. A melting point thereof was 120 C. to 121 C.10066] ?H-NMR (CDC13) oeppm: 2.40 (3H, s), 5.31 (2H, s), 6.10-6.91 (2H, br), 6.46 (1H, d), 6.89 (1H, d), 7.00 (1H, t), 7.16 (2H, d), 7.43 (2H, d), 7.67-7.72 (1H, t), 8.03 (1H, d), 8.20 (1H, d)

With the rapid development of chemical substances, we look forward to future research findings about 846021-26-9.

Reference:
Patent; AGRO-KANESHO CO., LTD.; AIZAWA, Ryo; OKADA, Itaru; (8 pag.)US2016/318868; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 846021-26-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 846021-26-9, name is 2-Amino-6-methylnicotinic acid. This compound has unique chemical properties. The synthetic route is as follows.

2-Amino-6-methyl nicotinic acid (3.04 g) was suspended in N,N-dimethylformamide (60 mL), and potassium carbonate (5.53 g) was added to the suspension, followed by stirring at 40 C. for 30 minutes. Solution (I) was dropwise added to the resulting suspension, followed by stirring with heating at 80 C. for 2 hours. The reaction solution was cooled to room temperature, and the N,N-dimethylformamide (45 mL, 64%) was removed by distillation under reduced pressure. Iced water (100 mL) was added to the residue, followed by stirring at room temperature for minutes. Precipitated crystals were collected by filtration and were dried to give 6.42 g (yield: 92%) of the target product (Compound 4 shown in Table 1). According to purity analysis by liquid chromatography, the purity of thus obtained target product was high, 99.1%. A melting point thereof was 94 C. to 96 C.10058] ?H-NMR (CDC13) oeppm: 2.33 (3H, s), 2.40 (3H, s), 5.27 (2H, s), 6.08-6.82 (2H, br), 6.44 (1H, d), 6.90-7.00 (5H, m), 7.14 (2H, d), 7.37 (2H, d), 8.02 (1H, d)

According to the analysis of related databases, 846021-26-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; AGRO-KANESHO CO., LTD.; AIZAWA, Ryo; OKADA, Itaru; (8 pag.)US2016/318868; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 846021-26-9 ,Some common heterocyclic compound, 846021-26-9, molecular formula is C7H8N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A mixture of 2-Amino-6-methyl-1licotinic acid (1.44 g, 9.46 mmol) and formamide (8.0 g, 178 mmol) was stirred at 170C for 2 hours. After cooling, the mixture was quenched with water (4 mL). The precipitate was filtered, washed with water and dried to afford 7-Methyl-pyrido [2,3-d] pyrimidin-4-ol (0.79g, 51%). 1H NMR (CDC13, 400 MHz) 8 8.49 (d, J=8.4Hz, 1H), 8.22 (s, 1H), 7.35 (d, J=8. 0Hz, 1H), 2.75 (s, 3H). MS (APCI+) [M+H] +162.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 846021-26-9, 2-Amino-6-methylnicotinic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ARRAY BIOPHARMA INC.; WO2005/51304; (2005); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 846021-26-9, name is 2-Amino-6-methylnicotinic acid. This compound has unique chemical properties. The synthetic route is as follows. Formula: C7H8N2O2

Production example 63 A mixture of 0.27 g of 4-(3-methoxyphenoxy)benzylamine, 0.15 g of 2-amino-6-methylnicotinic acid, 0.15 g of 1-hydroxybenzotriazole, 0.25 g of WSC, 0.35 g of pyridine and 2 ml ofDMF was stirred under heating to reflux for 30 minutes, and then at a room temperature for 1 day. Thereafter, water was added to the reaction mixture, and the precipitated solid was collected by filtration. The obtained solid was successively washed with a sodium bicarbonate aqueous solution, water, MTBE and hexane, and it was then dried, so as to obtain 0.25 g of N-[4-(3-methoxyphenoxy)phenyl]methyl-2-amino-6-methylnicotinic acid amide (hereinafter referred to as the present compound 79).The present compound 79 [Show Image] 1H-NMR (CDCl3) delta: 2.38 (3H, s), 3.78 (3H, s), 4.56 (2H, d, J = 5.6 Hz), 6.24 (1H, br s), 6.38 (2H, br s), 6.44 (1H, d, J = 7.7 Hz), 6.53-6.68 (3H, m), 7.00 (2H, d, J = 8.7 Hz), 7.20-7.25 (1H, m), 7.28-7.32 (2H, m), 7.49 (1H, d, J = 7.7 Hz).

With the rapid development of chemical substances, we look forward to future research findings about 846021-26-9.

Reference:
Patent; Sumitomo Chemical Company, Limited; EP2248423; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem