Category: 846036-96-2

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 846036-96-2, name is (4-Amino-6-chloropyridin-3-yl)methanol. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C6H7ClN2O

Scheme 8 compound 4 (600 mg, 3.77 mmol) was dissolved in THF (50 mL). To this solution was added Mn02 (3.32 g, 37.7 mmol) in one portion. The resulting mixture was stirred at RT for 5 h. TLC showed the reaction completed. The solid Mn02 was filtered out. The filtrate was concentrated to give compound 5 (3.7 g, yield: 86.5%>) as a white solid.

With the rapid development of chemical substances, we look forward to future research findings about 846036-96-2.

Reference:
Patent; MANNKIND CORPORATION; TOLERO PHARMACEUTICALS, INC.; ZENG, Qingping; FARIS, Mary; MOLLARD, Alexis; WARNER, Steven L.; FLYNN, Gary A.; WO2014/52365; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 846036-96-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.846036-96-2, name is (4-Amino-6-chloropyridin-3-yl)methanol, molecular formula is C6H7ClN2O, molecular weight is 158.59, as common compound, the synthetic route is as follows.

Manganese dioxide (230 g, 2648 mmol) was added to a solution of (4-amino-6- chloropyridin-3-yl)methanol (50 g, 265 mmol) in dichloromethane (3000 mL) at 0 C under nitrogen. The resulting reaction mixture was allowed to warm to room temperature and stirred for sixteen hours. On completion, the reaction mixture was filtered through a Celite pad and the residue was washed with dichloromethane and the filtrate was evaporated under reduced pressure. The solid was washed with pentane to afford 4-amino-6-chloronicotinaldehyde (41 g, 237 mmol, 89 % yield) as an off white solid. 1H NMR (400 MHz, CD3SOCD3) delta 6.73 (s, 1 H), 7.69-7.91 (m, 2 H), 8.43 (s, 1 H), 9.88 (s, 1 H); LC-MS (LC-ES) M+H = 157.

Statistics shows that 846036-96-2 is playing an increasingly important role. we look forward to future research findings about (4-Amino-6-chloropyridin-3-yl)methanol.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; DEATON, Dave Norman; SHEARER, Barry George; YOUNGMAN, Mark Andrew; (214 pag.)WO2018/229629; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 846036-96-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 846036-96-2, name is (4-Amino-6-chloropyridin-3-yl)methanol. A new synthetic method of this compound is introduced below.

To a solution of (4-amino-6-chloro-pyridin-3-yl)-methanol (0.335 g, 2.1 mmol) (from Example 23 supra) in dichloromethane (100 mL) at room temperature was added MnO2 (1.9 g, 21.8 mmol). The reaction mixture was stirred at this temperature for 16 hours then filtered. Solvent was evaporated to give 4-amino-6-chloro-pyridine-3-carbaldehyde as a white solid which was used directly in the next step. (Yield 0.275 g, 83.9%). 1H NMR (300 MHz, CDCl3): delta 9.90 (s, 1H), 8.38 (s, 1H), 6.58 (s, 1H), 1.57 (s, 2H). LC-MS: [M+H]+ 157.1.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,846036-96-2, (4-Amino-6-chloropyridin-3-yl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; Luk, Kin-Chun; US2012/184562; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.846036-96-2, name is (4-Amino-6-chloropyridin-3-yl)methanol, molecular formula is C6H7ClN2O, molecular weight is 158.59, as common compound, the synthetic route is as follows.HPLC of Formula: C6H7ClN2O

(4-Amino-6-chloropyridin-3-yl)methanol (2.6 g, 16.4 mmol) was dissolved in DCM (80 mL) along with Mn02 (14.3 g). The mixture was stirred at rt for 24 h. Mn02 was filtered off andthe filtrate was concentrated to afford 4-amino-6-chloronicotinaldehyde (1.67 g, 65%) as a white solid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,846036-96-2, (4-Amino-6-chloropyridin-3-yl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; PRINCIPIA BIOPHARMA, INC.; VERNER, Erik; BRAMELD, Kenneth Albert; WO2015/120049; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem