Category: 84703-18-4

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 84703-18-4, name is 5-Bromo-2-chloro-6-methylnicotinonitrile, molecular formula is C7H4BrClN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 84703-18-4

Step 1: 5-bromo-2-chloro-6-methylnicotinaldehyde (119b) To a solution of 5-bromo-2-chloro-6-methylnicotinonitrile (0.20 g, 0.86 mmol) in DCM (200 mL) was successively added DIBAL (0.86 mL, 1.30 mmol) at -78 C. under N2. The reaction mixture was stirred at room temperature for 2 h. the mixture was diluted with water and EtOAc. The organic layer was separated and the aqueous layer extracted with EtOAc. The residue was purified by column chromatography on silica gel to give 119b (20.0 g, 60.4%) as a yellow solid. LC-MS (ESI): m/z=233.9 [M+H]+

With the rapid development of chemical substances, we look forward to future research findings about 84703-18-4.

Reference:
Patent; Fronthera U.S. Pharmaceuticals LLC; JIN, Bohan; DONG, Qing; HUNG, Gene; LI, Yao; (169 pag.)US2019/367515; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 84703-18-4, Adding some certain compound to certain chemical reactions, such as: 84703-18-4, name is 5-Bromo-2-chloro-6-methylnicotinonitrile,molecular formula is C7H4BrClN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 84703-18-4.

General procedure: A mixture of 10a-10k (1 mmol), methyl thioglycolate (159 mg,1.5 mmol) and Et3N (152 mg, 1.5 mmol) in 10 mL of methanol was stirred at 80 C for 6-8 h. Methanol was removed under vacuum.The residuewas purified by column chromatography to provide thetitle compound.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 84703-18-4, 5-Bromo-2-chloro-6-methylnicotinonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Zhao, Yan; Li, Min; Li, Bowen; Zhang, Shun; Su, Aoze; Xing, Yongning; Ge, Zemei; Li, Runtao; Yang, Baoxue; European Journal of Medicinal Chemistry; vol. 172; (2019); p. 131 – 142;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem