Category: 847225-56-3

Li, Yan published the artcilePalladium-catalyzed cross-coupling of benzyltitanium(IV) reagents with aryl fluorides, Name: 4-Fluoropicolinonitrile, the publication is Monatshefte fuer Chemie (2022), 153(2), 193-199, database is CAplus.

The first palladium-catalyzed cross-coupling between benzyltitanium(IV) reagents with aryl fluorides is reported. A variety of diarylmethanes can be prepared in good to excellent yields by the catalyst system of PdCl₂(dppf)₂ associated with 1-[2-(di-tert-butylphosphanyl)phenyl]-4-methoxypiperidine. This reaction offered a highly efficient approach to diarylmethanes that are commonly found in life-changing drug mols.

Monatshefte fuer Chemie published new progress about 847225-56-3. 847225-56-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Fluoride,Nitrile, name is 4-Fluoropicolinonitrile, and the molecular formula is C6H3FN2, Name: 4-Fluoropicolinonitrile.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Li, Yan published the artcilePalladium-catalyzed cross-coupling of benzyltitanium(IV) reagents with aryl fluorides, Name: 4-Fluoropicolinonitrile, the publication is Monatshefte fuer Chemie (2022), 153(2), 193-199, database is CAplus.

The first palladium-catalyzed cross-coupling between benzyltitanium(IV) reagents with aryl fluorides is reported. A variety of diarylmethanes can be prepared in good to excellent yields by the catalyst system of PdCl₂(dppf)₂ associated with 1-[2-(di-tert-butylphosphanyl)phenyl]-4-methoxypiperidine. This reaction offered a highly efficient approach to diarylmethanes that are commonly found in life-changing drug mols.

Monatshefte fuer Chemie published new progress about 847225-56-3. 847225-56-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Fluoride,Nitrile, name is 4-Fluoropicolinonitrile, and the molecular formula is C6H3FN2, Name: 4-Fluoropicolinonitrile.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Tamura, Masazumi published the artcileCeO₂-catalyzed nitrile hydration to amide: reaction mechanism and active sites, Formula: C6H3FN2, the publication is Catalysis Science & Technology (2013), 3(5), 1386-1393, database is CAplus.

CeO₂ acted as a reusable and effective catalyst for the hydration of various nitriles to amides in water, under neutral conditions at low temperature (30-100 °C). To identify the active site, we examined the relationship between activity and the amount of the pair site of a low-coordinated Ce site (Ce_LC) (oxygen defect site) and adjacent Lewis base (exposed oxygen), determined by methanol adsorption on FTIR. It is revealed that the Ce_LC-O site is the active site for the reaction. To clarify the reaction mechanism, we carried out in situ FTIR studies on the reaction of acetonitrile with surface Ce-OH groups and kinetic studies such as H₂O/D₂O kinetic isotope effect and Hammett plot. The results give the following catalytic cycle: (1) dissociation of H₂O on the Ce_LC-O site (oxygen defect site) to give OH^δ- and H^δ+ species on the site, (2) formation of an adsorption complex between nitrile and CeO₂, (3) addition of OH^δ- to the carbon atom of the cyano group of the complex and (4) desorption of the amide from the CeO₂ surface, accompanying a regeneration of the Ce_LC-O site. On the basis of the above fundamental information, we found a simple method for activity increase; preheating of CeO₂ at 600 °C resulted in desorption of surface carbonate, and the exposed Ce_LC-O site thus prepared showed one order of magnitude higher activity for the hydration of various nitriles than untreated CeO₂.

Catalysis Science & Technology published new progress about 847225-56-3. 847225-56-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Fluoride,Nitrile, name is 4-Fluoropicolinonitrile, and the molecular formula is C9H5ClO2, Formula: C6H3FN2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zhu, Shengqing published the artcilePhotoredox-catalyzed branch-selective pyridylation of alkenes for the expedient synthesis of Triprolidine, Synthetic Route of 847225-56-3, the publication is Nature Communications (2019), 10(1), 1-7, database is CAplus.

A catalytic, branch-selective pyridylation of alkenes via a sulfinate assisted photoredox catalysis was reported. This reaction proceeded through a sequential radical addition/coupling/elimination, by utilizing readily available sodium sulfinates as reusable radical precursors as well as traceless elimination groups. This versatile protocol allows for the installation of important vinylpyridines with complete branched selectivity under mild conditions. Furthermore, this catalytic manifold was successfully applied to the expedient synthesis of Triprolidine.

Nature Communications published new progress about 847225-56-3. 847225-56-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Fluoride,Nitrile, name is 4-Fluoropicolinonitrile, and the molecular formula is C19H14N2, Synthetic Route of 847225-56-3.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

La Beaume, Paul published the artcileMicrowave-accelerated fluorodenitrations and nitrodehalogenations: expeditious routes to labeled PET ligands and fluoropharmaceuticals, COA of Formula: C6H3FN2, the publication is Tetrahedron Letters (2010), 51(14), 1906-1909, database is CAplus.

Methods for the expeditious fluorination of arenes have been investigated, using readily available fluoride sources. An optimized procedure for microwave-accelerated fluorodenitration has been developed, giving good to excellent yields in less than 10 min, rendering it practical for use in the preparation of F¹⁸ labeled ligands for PET imaging. Application of the method in the synthesis of CNS agents is demonstrated, and a practical method for the preparation of substrates is also presented.

Tetrahedron Letters published new progress about 847225-56-3. 847225-56-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Fluoride,Nitrile, name is 4-Fluoropicolinonitrile, and the molecular formula is C6H3FN2, COA of Formula: C6H3FN2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Moree, Wilna J. published the artcileNovel benzothiophene H₁-antihistamines for the treatment of insomnia, Name: 4-Fluoropicolinonitrile, the publication is Bioorganic & Medicinal Chemistry Letters (2010), 20(7), 2316-2320, database is CAplus and MEDLINE.

SAR of lead benzothiophene H₁-antihistamine I (R = 2-pyridyl) was explored to identify backup candidates with suitable pharmacokinetic profiles for an insomnia program. Several potent and selective H₁-antihistamines with a range of projected half-lives in humans were identified. Had a suitable human half-life as demonstrated in a human microdose study, but variability in pharmacokinetic profile, attributed to metabolic clearance, prevented further development of this compound I (R = 1-pyrazolyl) demonstrated lower predicted clearance in preclin. studies, and may represent a more suitable backup compound

Bioorganic & Medicinal Chemistry Letters published new progress about 847225-56-3. 847225-56-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Fluoride,Nitrile, name is 4-Fluoropicolinonitrile, and the molecular formula is C6H3FN2, Name: 4-Fluoropicolinonitrile.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Kuduk, Scott D. published the artcileTetrabutylammonium salt induced denitration of nitropyridines: synthesis of fluoro-, hydroxy-, and methoxypyridines, Safety of 4-Fluoropicolinonitrile, the publication is Organic Letters (2005), 7(4), 577-579, database is CAplus and MEDLINE.

An efficient method for the synthesis of fluoropyridines by the fluorodenitration reaction is reported. The reaction was mediated by tetrabutylammonium fluoride under mild conditions without undue regard to the presence of water. The fluorodenitration was general for 2- or 4-nitro-substituted pyridines, while 3-nitropyridines required attendant electron-withdrawing groups for the reaction to proceed efficiently. Nitropyridines also underwent hydroxy- and methoxydenitration under mild conditions in the presence of the corresponding tetrabutylammonium species.

Organic Letters published new progress about 847225-56-3. 847225-56-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Fluoride,Nitrile, name is 4-Fluoropicolinonitrile, and the molecular formula is C6H3FN2, Safety of 4-Fluoropicolinonitrile.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem