Category: 848498-98-6

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 848498-98-6, name is 2,6-Dichloro-N-methoxy-N-methylisonicotinamide, the common compound, a new synthetic route is introduced below. Product Details of 848498-98-6

A mixture of 88-1 (20.0 g, 85.1 mmol), boronic acid (13.1 g, 93.6 mmol), Pd(dppf)Cl2 (3.1 g, 4.25 mmol) and TBAF (1 M, 127.6 mL) in DCM (400 mL) was stirred at 25 C. for 12 h under N2. The solution was concentrated, and the residue was diluted with H2O (1 L) and extracted with EA (800 mL). The organic phase was washed with brine, dried with anhydrous Na2SO4, filtered and concentrated. The residue was purified by column chromatography using 520% EA in PE as eluent to give 88-2 (17.2 g, 68.6%) as a yellow oil. MS: m/z 295.7 [M+H]+.

The synthetic route of 848498-98-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Alios BioPharma, Inc.; Wang, Guangyi; Beigelman, Leonid; Truong, Anh; Stein, Karin Ann; (234 pag.)US2016/244460; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 848498-98-6 ,Some common heterocyclic compound, 848498-98-6, molecular formula is C8H8Cl2N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

[0365] l-(2,6-Dichloro-4-pyridinyl)ethanone (156). A solution of MeMgBr (3 M in Et2O, 4.3 mL, 12.8 mmol) was added slowly to a stirred solution of amide 155 (2.0 g, 8.5 mmol) in dry THF (40 mL) at 0 0C and the mixture was stirred at 0 0C for 3 h. The reaction mixture was quenched with aq. NH4Cl solution (15 mL) and the mixture extracted with EtOAc (3 x 50 mL). The combined organic fraction was washed with water (50 mL), washed with brine (50 mL), dried and the solvent evaporated. The crude product was recrystallized to give the ketone 156 as white crystals (1.61 g, 99%): mp (EtOAc) 50-51 C; 1H NMR (CDCl3) delta 7.68 (s, 2 H, H- 3′, H-5′), 2.61 (s, 3 H, H-2); MS m/z 190.4, 192.4 (MH+, 100, 70%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 848498-98-6, 2,6-Dichloro-N-methoxy-N-methylisonicotinamide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY; AUCKLAND UNISERVICES LIMITED; WO2009/114552; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem