Category: 850429-51-5

Synthetic Route of 850429-51-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 850429-51-5, name is Ethyl 6-amino-5-bromonicotinate, molecular formula is C8H9BrN2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A) To a solution of ethyl 6-amino-5-bromonicotinate (2.31 g, 10 mmol) in tetrahydrofuran (20 mL) at RT was added LAH (10 mL, IM in tetrahydrofuran) dropwise. After stirring for Ih, the mixture was quenched with water (0.2 mL) and the resultant precipitate was filtered and washed with ethyl acetate. The filtrate was concentrated in vacuo to afford (6-amino-5-bromopyridin-3-yl)methanol (2.0 g, 99%) as a solid. LC/MS; (M+H)+ = 203, 205 (1 : 1 ratio). 1H NMR (CD3OD, 300 MHz) delta 7.79 (s, IH), 7.67 (s, IH), 4.35 (br S, 2H).

According to the analysis of related databases, 850429-51-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2008/60907; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 850429-51-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 850429-51-5, name is Ethyl 6-amino-5-bromonicotinate. A new synthetic method of this compound is introduced below.

2.41 g of ethyl 2-amino-3-bromo-5-pyridinecarboxylate 3d in 120 mL of methanol and 2.8 g of potassium hydroxide in 40 mL of water are placed in a round-bottomed flask. The mixture is stirred with heating at 60 C. for 3 hours. The methanol is evaporated off. After cooling, 10 mL of 5N hydrochloric acid are added. The precipitate is filtered off to give 2.07 g of 6-amino-5-bromonicotinic acid.LC-MS-DAD-ELSD: 217(+) and 219(+)=(M+H)(+) Rt (min)=1.71

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,850429-51-5, its application will become more common.

Reference:
Patent; SANOFI-AVENTIS; US2011/178053; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem