Related Products of 851179-00-5 , The common heterocyclic compound, 851179-00-5, name is 3-Chloro-2,5-difluoropyridine, molecular formula is C5H2ClF2N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Cesium carbonate (476 mg, 1 .46 mmol) was added to a mixture of 3-chloro-2,5-difluoropyridine (97%, 150 mg, 0.97 mmol) and C5 (366 mg, 0.972 mmol) in dimethyl sulfoxide (5 ml), and the reaction mixture was stirred at 80 C for 6 hours. Water was added, and the mixture was extracted three times with ethyl acetate; the combined organic layers were washed with saturated aqueous sodium chloride solution, dried over sodium sulfate, filtered, and concentrated in vacuo. Silica gel chromatography (Gradient: 10% to 40% ethyl acetate in heptane) provided the product as a sticky solid. Yield: 414 mg, 0.818 mmol, 84%. 1 H NMR (400 MHz, CDCl3) delta 7.96 (d, J=2.7 Hz, 1 H), 7.64 (dd, J=7.1 , 2.7 Hz, 1 H), 7.09-7.15 (m, 3H), 5.51 (AB quartet, JAB=9.3 Hz, DeltanuAlphaBeta=3.4 Hz, 2H), 3.74-3.80 (m, 2H), 3.07 (s, 3H), 2.19 (s, 3H), 1 .69 (s, 3H), 1.00-1.06 (m, 2H), 0.03 (s, 9H).
The synthetic route of 851179-00-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PFIZER INC.; BRODNEY, Michael Aaron; DAVOREN, Jennifer Elizabeth; DOUNAY, Amy Beth; EFREMOV, Ivan Viktorovich; GRAY, David Lawrence Firman; GREEN, Michael Eric; HENDERSON, Jaclyn Louise; LEE, Chewah; MENTE, Scot Richard; O’NEIL, Steven Victor; ROGERS, Bruce Nelsen; ZHANG, Lei; WO2014/207601; (2014); A1;,
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