Adding a certain compound to certain chemical reactions, such as: 851386-34-0, 2,3-Difluoro-4-iodopyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C5H2F2IN, blongs to pyridine-derivatives compound. Formula: C5H2F2IN
Tetrakis(triphenylphosphine)palladium(0) (1.91 mg, 1.66 mmol) was added to a solution of methyl 3-amino-5-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-2-nitrobenzoate (6.1 g, 19.9 mmol), 2,3-difluoro-4-iodopyridine (4.0 g, 16.6 mmol), and potassium phosphate tribasic (10.6 g, 49.8 mmol) in dioxane (80 mL) and water (20 mL). Nitrogen was bubbled for 10 minutes and the reaction mixture was stirred at 80° C. for 10 hours. Upon cooling, the reaction mixture was partitioned between ethyl acetate and water. The organic phase was washed with brine, dried with magnesium sulfate, filtered, and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography eluting with 5 to 70percent of (5percent methanol in ethyl acetate) in hexane to afford methyl 3-amino-5-(2,3-difluoropyridin-4-yl)-2-nitrobenzoate. ES/MS m/z=310.2 (M+H)+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,851386-34-0, 2,3-Difluoro-4-iodopyridine, and friends who are interested can also refer to it.
Reference:
Patent; Gilead Sciences, Inc.; Chandrasekhar, Jayaraman; Patel, Leena; Perreault, Stephane; Phillips, Gary; Till, Nicholas Alexander; Treiberg, Jennifer Anne; (118 pag.)US2018/86768; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem