Category: 851484-95-2

Reference of 851484-95-2 ,Some common heterocyclic compound, 851484-95-2, molecular formula is C6H3ClFNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of hydroxylamine hydrochloride (0.410 g, 5.902 mmol) in H20 (7.5 mL) was added a solution of 2-chloro-5-fluoronicotinaldehyde (0.856 g, 5.365 mmol) in EtOH (10 mL) in one portion. White solid came out. After stirring at room temperature for 1 h, water (10 mL) was added. The white solid was filtered off to give the intermediate (0.92 g).To a suspension of the solid obtained above in CH2C12 (15 mL) under nitrogen was added carbonyl diimidazole (1.044 g, 6.438 mmol) and the suspension became a clear solution. The mixture was heated at reflux for 1 h and concentrated. The residue was purified by silica gel chromatography (15% hexanes/EtOAc) to give the title compound (0.752 g, 4.804 mmol, 89.5% yield) as white solid. ‘H NMR (CDC13 , 400 MHz) ? ppm 7.75 (dd, / = 6.8 and 3.0 Hz, IH), 8.49 (d, 7 = 3.0 Hz, IH).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,851484-95-2, its application will become more common.

Reference:
Patent; ARENA PHARMACEUTICALS, INC.; JONES, Robert M.; BUZARD, Daniel J.; HAN, Sangdon; KIM, Sun Hee; LEHMANN, Juerg; ZHU, Xiuwen; WO2013/55910; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 851484-95-2, name is 2-Chloro-5-fluoronicotinaldehyde. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 2-Chloro-5-fluoronicotinaldehyde

2-chloro-5-fluoronicotinaldehyde (20 g, 125 mmol) was taken up in THF (150 ml) at 0 C. (R)-2-Methylpropane-2-sulfinamide (16.71 g, 138 mmol) was added followed by dropwise additionof titaniumtetraethanolate (22.88 ml, 150 mmol). The reaction mixture was stirred while warming to RT. After 3 hours the reaction mixture was cooled to 0 C, and 150m1 of brine was added and stirred for 20 minutes. The mixture was filtered through Celite. The aqueous layer was separated and discarded. The organic layer with dried over Na2SO4 and the solvent was removed to give(S ,Z)-N-((2-chloro-5-fluoropyridin-3 -yl)methylene)-2-methylpropane-2- sulfinamide (32 g, 122 mmol, 97 % yield), which was carried on without further purification. LCMS: 263 M+H.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 851484-95-2, 2-Chloro-5-fluoronicotinaldehyde.

Reference:
Patent; BLUEPRINT MEDICINES CORPORATION; WENGLOWSKY, Steven, Mark; MIDUTURU, Chandrasekhar, V.; BIFULCO, Neil, Jr; KIM, Joseph, L.; (91 pag.)WO2017/87778; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 851484-95-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 851484-95-2, name is 2-Chloro-5-fluoronicotinaldehyde, molecular formula is C6H3ClFNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

2-chloro-5-fluoronicotinaldehyde (20 g, 125 mmol) was taken up in THF (150 ml) at 0 C. (R)-2-Methylpropane-2-sulfinamide (16.71 g, 138 mmol) was added followed by dropvvise addition of iitaniumtetraethanolaie (22.88 ml, 150 mmol). The reaction mixture was stirred while warming to RT. After 3 hours the reaction mixture was cooled to 0 C, and 150ml of brine was added and stirred for 20 minutes. The mixture was filtered through Celite. The aqueous layer was separated and discarded. The organic layer with dried over Na2S04 and the solvent was removed to give (S,Z)-N-((2-chloro-5-fluoropyridm-3-yl)memylene)-2-methylpropane-2-sul.finaiTiide (32 g, 122 mmol, 97 % yield), which was carried on without further purification. LCMS: 263 M+H.

According to the analysis of related databases, 851484-95-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BLUEPRINT MEDICINES CORPORATION; WENGLOWSKY, Steven, Mark; BROOIJMANS, Natasja; MIDUTURU, Chandrasekhar, V.; BIFULCO, Neil; (206 pag.)WO2017/35354; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 851484-95-2, Adding some certain compound to certain chemical reactions, such as: 851484-95-2, name is 2-Chloro-5-fluoronicotinaldehyde,molecular formula is C6H3ClFNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 851484-95-2.

Example 37: Synthesis of 3-Fluoro-l,7,llb-triaza-benzo[c]fluorene-6-carboxylic acid ethyl es [0321] To a solution of compound SMI (0.8 g, 5 mmol) and compound SM2 (1.02 g, 5 mmol) in ethanol (50 mL) was added piperidine (1.28 g, 15 mmol) and the mixture was stirred at room temperature for 20 min. The reaction mixture was heated to reflux for 16h. After cooling, the mixture was filtered and washed with ethanol, dried to get compound 7A as yellow solid (0.82 g, 79 yield). LCMS: m/z 309.9 (M+H)+.

According to the analysis of related databases, 851484-95-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; HADDACH, Mustapha; WO2015/172123; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 851484-95-2, 2-Chloro-5-fluoronicotinaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 851484-95-2, blongs to pyridine-derivatives compound. Safety of 2-Chloro-5-fluoronicotinaldehyde

2-chloro-5-fluoro-pyridine-3-carbaldehyde (1.00 g, 6 · 27 mmol) was added to a 20 ml microwave vial, 2-benzyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1.1 equivalents, 6.89 mmol) [1,1′-bis (diphenylphosphino) ferrocene] palladium (II) dichloride (PdCl2 (dppf); 0 ? 1 equivalent, 0.63 mmol ) And powdered sodium carbonate (3 equiv., 18.8 mmol). Add 1,4-dioxane (9 mL) and water (5 mL) The mixture was rinsed with nitrogen and then passed through a microwave 90 C under heating for two 2 hours. The cooled mixture was then directly adsorbed onto silica and purified by trituration on a 40 g silica gel column eluting with isohexane: ethyl acetate (100%: 0% to 70%: 30%) to afford the title compound as a colorless oil 2-benzyl-5-fluoro-pyridine-3-carbaldehyde (460 mg).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,851484-95-2, its application will become more common.

Reference:
Patent; Xian Zheng Da Cangu Co., Ltd.; G ·mixieer; G ·muensi; N ·P·maerhuolande; M ·C·pulaien; (42 pag.)CN106715425; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 851484-95-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 851484-95-2, name is 2-Chloro-5-fluoronicotinaldehyde, molecular formula is C6H3ClFNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

In a 250 mL flask, 2-chloro-5-fluoropyridine-3-carboxaldehyde (4. 88 g, 31. 0 mmol) was dissolved in dioxane (103 mL) along with Boc-piperazine (5.77 g, 31. 0 mmol) and potassium carbonate (4.30 g, 31. 0 mmol). The reaction was heated to reflux with stirring for 48 hours. The mixture was then diluted with ethyl acetate (100 mL) and washed with saturated NaHC03 solution (2 x 75 mL) and saturated NaCI solution (2 x 75 mL). The organic layer was collected, dried overanhydrous Na2SO4, and then filtered. Solvent was removed iii vacuo and the residue was purified by column chromatography on silica using 9: 1 hexane/ethyl acetate as the eluent to afford 3. 0g (31%) of the 20a as a yellow solid.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 851484-95-2, 2-Chloro-5-fluoronicotinaldehyde.

Reference:
Patent; NEUROCRINE BIOSCIENCES, INC.; WO2005/40109; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem