Category: 85237-71-4

Li, Yan published the artcilePotassium tert-butoxide promoted regioselective deuteration of pyridines, Formula: C13H13N, the publication is Chemical Communications (Cambridge, United Kingdom) (2022), 58(21), 3497-3500, database is CAplus and MEDLINE.

A regioselective deuteration at the β- and γ-position of pyridines was reported. Efficient deuteration occurred with a combination of KO^tBu and DMSO-d₆, replenishing the prevailing α-deuteration of the pyridine systems. Preliminary mechanistic studies suggested that the dimsyl carbanion acts as one of the key intermediates.

Chemical Communications (Cambridge, United Kingdom) published new progress about 85237-71-4. 85237-71-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is 5-Methyl-2-(p-tolyl)pyridine, and the molecular formula is C13H13N, Formula: C13H13N.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Liu, Chun published the artcileA fast and oxygen-promoted protocol for the ligand-free Suzuki reaction of 2-halogenated pyridines in aqueous media, Category: pyridine-derivatives, the publication is Chemical Communications (Cambridge, United Kingdom) (2009), 6267-6269, database is CAplus and MEDLINE.

A fast protocol has been developed for the construction of 2-aryl-substituted pyridine derivatives by the oxygen-promoted, ligand-free, Pd(OAc)₂-catalyzed Suzuki reaction of 2-halogenated pyridines in aqueous isopropanol.

Chemical Communications (Cambridge, United Kingdom) published new progress about 85237-71-4. 85237-71-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is 5-Methyl-2-(p-tolyl)pyridine, and the molecular formula is C13H13N, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zhang, Qian published the artcileDDQ: the chlorinating reagent and oxidant for the ligand-directed ortho-chlorination of 2-arylpyridines, Quality Control of 85237-71-4, the publication is Organic Chemistry Frontiers (2014), 1(6), 694-697, database is CAplus.

A new and simple protocol for palladium-catalyzed ligand-directed ortho-chlorination of 2-arylpyridines with DDQ was developed, generating the chlorinated products in good to excellent yields. DDQ played dual role as both the chlorinating reagent and oxidant in this reaction. Moreover, high regioselectivity was observed for 2-arylpyridines bearing a meta-substituent in the aryl ring moiety, and chlorination could take place at the less sterically hindered ortho-C-H bond.

Organic Chemistry Frontiers published new progress about 85237-71-4. 85237-71-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is 5-Methyl-2-(p-tolyl)pyridine, and the molecular formula is C3H6BrNaO3S, Quality Control of 85237-71-4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Li, Yan published the artcilePotassium tert-butoxide promoted regioselective deuteration of pyridines, Formula: C13H13N, the publication is Chemical Communications (Cambridge, United Kingdom) (2022), 58(21), 3497-3500, database is CAplus and MEDLINE.

A regioselective deuteration at the β- and γ-position of pyridines was reported. Efficient deuteration occurred with a combination of KO^tBu and DMSO-d₆, replenishing the prevailing α-deuteration of the pyridine systems. Preliminary mechanistic studies suggested that the dimsyl carbanion acts as one of the key intermediates.

Chemical Communications (Cambridge, United Kingdom) published new progress about 85237-71-4. 85237-71-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is 5-Methyl-2-(p-tolyl)pyridine, and the molecular formula is C13H13N, Formula: C13H13N.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Liu, Chun published the artcileA fast and oxygen-promoted protocol for the ligand-free Suzuki reaction of 2-halogenated pyridines in aqueous media, Category: pyridine-derivatives, the publication is Chemical Communications (Cambridge, United Kingdom) (2009), 6267-6269, database is CAplus and MEDLINE.

A fast protocol has been developed for the construction of 2-aryl-substituted pyridine derivatives by the oxygen-promoted, ligand-free, Pd(OAc)₂-catalyzed Suzuki reaction of 2-halogenated pyridines in aqueous isopropanol.

Chemical Communications (Cambridge, United Kingdom) published new progress about 85237-71-4. 85237-71-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is 5-Methyl-2-(p-tolyl)pyridine, and the molecular formula is C13H13N, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zhang, Qian published the artcileDDQ: the chlorinating reagent and oxidant for the ligand-directed ortho-chlorination of 2-arylpyridines, Quality Control of 85237-71-4, the publication is Organic Chemistry Frontiers (2014), 1(6), 694-697, database is CAplus.

A new and simple protocol for palladium-catalyzed ligand-directed ortho-chlorination of 2-arylpyridines with DDQ was developed, generating the chlorinated products in good to excellent yields. DDQ played dual role as both the chlorinating reagent and oxidant in this reaction. Moreover, high regioselectivity was observed for 2-arylpyridines bearing a meta-substituent in the aryl ring moiety, and chlorination could take place at the less sterically hindered ortho-C-H bond.

Organic Chemistry Frontiers published new progress about 85237-71-4. 85237-71-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is 5-Methyl-2-(p-tolyl)pyridine, and the molecular formula is C3H6BrNaO3S, Quality Control of 85237-71-4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zhou, Fei published the artcileNitroarenes as Nitrogen Source in Intermolecular Palladium-Catalyzed Aryl C-H Bond Aminocarbonylation Reactions, Name: 5-Methyl-2-(p-tolyl)pyridine, the publication is Angewandte Chemie, International Edition (2017), 56(16), 4530-4534, database is CAplus and MEDLINE.

A three-component palladium-catalyzed aminocarbonylation of aryl and heteroaryl sp² C-H bonds using nitroarenes as the nitrogen source was achieved using Mo(CO)₆ as the reductant and origin of the CO. This intermol. C-H bond functionalization does not requires any exogenous ligand to be added, and our mechanism experiments indicate that the palladacycle catalyst serves two roles in the aminocarbonylation reaction: reduce the nitroarene to a nitrosoarene and activate the sp² C-H bond.

Angewandte Chemie, International Edition published new progress about 85237-71-4. 85237-71-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is 5-Methyl-2-(p-tolyl)pyridine, and the molecular formula is C12H10O4S, Name: 5-Methyl-2-(p-tolyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Yoshida, Hiroto published the artcileDirect Suzuki-Miyaura Coupling with Naphthalene-1,8-diaminato (dan)-Substituted Organoborons, Safety of 5-Methyl-2-(p-tolyl)pyridine, the publication is ACS Catalysis (2020), 10(1), 346-351, database is CAplus.

The direct Suzuki-Miyaura coupling with “protected” R-B(dan) (dan = naphthalene-1,8-diaminato) (R = Ph, 4-MeOC₆H₄, 2-pyridyl) was demonstrated to smoothly occur without in situ deprotection of the B(dan) moiety. The use of KOt-Bu (Ba(OH)₂ in some cases) as a base under anhydrous conditions is the key to the successful cross-coupling, where R-B(dan) is readily converted into a transmetalation-active borate-form, regardless of the well-accepted diminished boron-Lewis acidity.

ACS Catalysis published new progress about 85237-71-4. 85237-71-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is 5-Methyl-2-(p-tolyl)pyridine, and the molecular formula is C10H12BF3KNO2, Safety of 5-Methyl-2-(p-tolyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Sindhuja, Elangovan published the artcilePalladium(II) thiocarboxamide complexes: synthesis, characterisation and application to catalytic Suzuki coupling reactions, Product Details of C13H13N, the publication is Dalton Transactions (2012), 41(17), 5351-5361, database is CAplus and MEDLINE.

A simple route to synthesize palladium(II) complexes from the reaction of N-substituted pyridine-2-thiocarboxamide ligands and PdCl₂(PPh₃)₂ has been developed. The new complexes are very soluble in common solvents and have been fully characterized (elemental anal., FTIR, ¹H, ³¹P, ¹³C-NMR), including an x-ray diffraction anal. The mol. structures of all the complexes were determined and reveal square planar geometry around Pd with little distortion. The complexes were tested in the Suzuki coupling of electronically deactivated aryl and heteroaryl bromides and have much greater activity, without using any promoting additives or phase transfer agent under aerobic conditions. Higher reaction rates were obtained by varying R substituents on the aromatic ring of pyridine-2-thiocarboxamide. The effect of other variables on the cross-coupling reaction, such as temperature, solvent and base, is also reported.

Dalton Transactions published new progress about 85237-71-4. 85237-71-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is 5-Methyl-2-(p-tolyl)pyridine, and the molecular formula is C17H20ClN3, Product Details of C13H13N.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Muralirajan, Krishnamoorthy published the artcileCobalt-Catalyzed Mild Ring-Opening Addition of Arenes C-H Bond to 7-Oxabicyclic Alkenes, Quality Control of 85237-71-4, the publication is Advanced Synthesis & Catalysis (2017), 359(3), 513-518, database is CAplus.

A mild approach for a Cp*Co(III)-catalyzed C-H naphthylation of arenes by 7-oxabicyclic alkenes has been developed. In some cases, intermediate products with a 1,2-dihydronaphthalen-1-ol group have been isolated at room temperature in good yield. The catalytic reaction proceeds via C-H activation, insertion, β-oxygen elimination, protonation, and dehydration, resp. These simple protocols, featuring mild conditions and tolerance of functional groups, exhibit great potential for a variety of synthetic applications.

Advanced Synthesis & Catalysis published new progress about 85237-71-4. 85237-71-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is 5-Methyl-2-(p-tolyl)pyridine, and the molecular formula is C13H13N, Quality Control of 85237-71-4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem