Category: 853909-08-7

Adding a certain compound to certain chemical reactions, such as: 853909-08-7, 5-Ethynyl-2-fluoropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 853909-08-7, blongs to pyridine-derivatives compound. HPLC of Formula: C7H4FN

A solution of 5-ethynyl-2-fluoro-pyridine (500 mg, 4.13 mmol), l-Boc-piperazine (923 mg, 4.95 mmol) and triethylamine (1.15 mL, 8.26 mmol) in MeCN (10 mL) was stirred at 60 C for 16 h. The reaction was poured into H20 (50 mL) and extracted with EtOAc (70 mL). The organic layer was separated, dried over Na2S04, filtered and concentrated under vacuum The residue was purified by silica gel chromatography (petroleum ehtenEtOAc, 10: 1 to 2: 1) to afford /e/ -butyl 4-(5-ethynyl-2-pyridyl)piperazine-l-carboxylate (630 mg, 79%) as white solid. lH NMR (CHLOROLORM-d, 400 MHz) d 8.24 (d, 1H, 7=2.2 Hz), 7.48 (dd, 1H, 7=2.3, 8.9 Hz), 6.48 (d, 1H, J= 8.8 Hz), 3.4-3.5 (m, 8H), 3.00 (s, 1H), 1.41 (s, 9H)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,853909-08-7, its application will become more common.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; BORRONI, Edilio; GOBBI, Luca; HONER, Michael; EDELMANN, Martin; MITCHELL, Dale; HARDICK, David; SCHMIDT, Wolfgang; STEELE, Christopher; MULLA, Mushtaq; (151 pag.)WO2019/121661; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 853909-08-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 853909-08-7, name is 5-Ethynyl-2-fluoropyridine. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: Under argon, to a solution containing 3-aminoquinuclidine bishydrochloridesalt 2 (212 mg, 1.00 mmol) and 1H-imidazole-1-sulfonyle azide 1 (232 mg, 1.10 mmol) in MeOH (6 mL) wasportion wise added K2CO3 (415 mg, 3.00 mmol) and next a catalyticamount of CuSO4, 5H2O (25 mg, 0.10 mmol). The reaction mixturewas stirred at room temperature for 6 h and then concentratedunder reduced pressure. The crude solid was solubilized in Et2O(10 mL), filtered and the precipitate washed with an additionalamount of Et2O (10 mL). The combined organic layers were reducedunder reduced pressure and the (R) intermediate 3a used in thenext step. After addition of MeOH (6 mL), the desired terminalalkyne 4 (1.00 mmol) and next CuSO4, 5H2O (25 mg, 0.10 mmol),sodium ascorbate (40 mg, 0.20 mmol) were successively added. Thereaction mixturewas stirred for 12 h at room temperature. Volatileswere evaporated under reduced pressure and the residue purifiedby flash chromatography. When some traces of imidazole wereobserved, EtOAc (20 mL) was added. After washing with water(2 10 mL), the organic layer was dried over MgSO4, filtered andevaporated under reduced pressure to afford the pure derivative of type IIIa.

According to the analysis of related databases, 853909-08-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; Ouach, Aziz; Pin, Frederic; Bertrand, Emilie; Vercouillie, Johnny; Gulhan, Zuhal; Mothes, Celine; Deloye, Jean-Bernard; Guilloteau, Denis; Suzenet, Franck; Chalon, Sylvie; Routier, Sylvain; European Journal of Medicinal Chemistry; vol. 107; (2016); p. 153 – 164;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 853909-08-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 853909-08-7, name is 5-Ethynyl-2-fluoropyridine, molecular formula is C7H4FN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Under an argon atmosphere, Au(PPh3)Cl (488 mg, 0.99 mmol), 6-fluoro-3-pyridylethyne (179 mg, 1.48 mmol) and ethanol (20 ml) were added to a 20 ml Schlenk tube, and then sodium ethoxide (408 mul, 1.04 mmol: 2.55 mol/L (liter) in ethanol solution) was added dropwise thereto and the mixture was stirred at room temperature for 17 hours. After completion of the reaction, the resulting white precipitate was filtered and successively washed with ethanol (12 ml .x. three times), water (12 ml .x. three times) and ethanol (6 ml .x. three times), followed by drying under vacuum to give 0.42 g of the desired compound as a yellow powder (yield: 73percent). 1H-NMR (400 MHz, CDCl3) delta: 8.35 (s, 1H), 7.81-7.87 (m, 1H), 6.80-6.84 (m, 1H) (FAB-MS) (M/Z): 580 (M+H)+ Luminescence analysis: (CHCl3, 77K, Ex250nm) lambda (nm): 413, 433, 442, 452 Elemental analysis: Found C: 51.76, H: 3.05, N: 2.51 Theoretical C: 51.83, H: 3.13, N: 2.42

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 853909-08-7, 5-Ethynyl-2-fluoropyridine.

Reference:
Patent; Ube Industries, Ltd.; EP1847545; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 853909-08-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 853909-08-7, name is 5-Ethynyl-2-fluoropyridine, molecular formula is C7H4FN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Under an argon atmosphere, Au(PPh3)Cl (488 mg, 0.99 mmol), 6-fluoro-3-pyridylethyne (179 mg, 1.48 mmol) and ethanol (20 ml) were added to a 20 ml Schlenk tube, and then sodium ethoxide (408 mul, 1.04 mmol: 2.55 mol/L (liter) in ethanol solution) was added dropwise thereto and the mixture was stirred at room temperature for 17 hours. After completion of the reaction, the resulting white precipitate was filtered and successively washed with ethanol (12 ml .x. three times), water (12 ml .x. three times) and ethanol (6 ml .x. three times), followed by drying under vacuum to give 0.42 g of the desired compound as a yellow powder (yield: 73percent). 1H-NMR (400 MHz, CDCl3) delta: 8.35 (s, 1H), 7.81-7.87 (m, 1H), 6.80-6.84 (m, 1H) (FAB-MS) (M/Z): 580 (M+H)+ Luminescence analysis: (CHCl3, 77K, Ex250nm) lambda (nm): 413, 433, 442, 452 Elemental analysis: Found C: 51.76, H: 3.05, N: 2.51 Theoretical C: 51.83, H: 3.13, N: 2.42

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 853909-08-7, 5-Ethynyl-2-fluoropyridine.

Reference:
Patent; Ube Industries, Ltd.; EP1847545; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem