Category: 85614-89-7

Weglinski, Zbigniew; Talik, Tadeusz published an article in 1982, the title of the article was Synthesis of some derivatives of nicotinic acid.Application In Synthesis of Ethyl 5-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate And the article contains the following content:

Hydroxynicotinic acids I (R = 4-Me, 5-Me; R1 = HO) and II (R = 5-Me, 6-Me; R1 = HO) were esterified in EtOH containing H2SO4 to give I and II (R1 = EtO) which were autoclaved with (NH4)2CO3 at 373°K to give I and II (R1 = H2N). Treatment of the Et esters with N2H4 in EtOH gave I and II (R1 = NHNH2). The experimental process involved the reaction of Ethyl 5-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate(cas: 85614-89-7).Application In Synthesis of Ethyl 5-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate

The Article related to nicotinate methylhydroxy amidation, nicotinamide methylhydroxy, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Application In Synthesis of Ethyl 5-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On March 20, 2008, Glatthar, Ralf; Johns, Donald; Umbricht, Daniel published a patent.Application of 85614-89-7 The title of the patent was Preparation of pyridine derivatives as modulators of metabotropic glutamate receptors. And the patent contained the following:

Title compounds represented by the formula I [wherein R1 – (un)substituted alkyl or benzyl; R2 = H, alkyl or (un)substituted benzyl; or R1R2N = (un)substituted heterocyclyl; R3 = halo, alkoxy, alkyl(amino) or dialkylamino; R4 = OH, halogen, alkyl or alkoxy; Q = CH, CR4 or N; V = CH, CR4 or N; W = CH, CR4 or N; X = CH or N; Y = CH, CR3 or N; Z = CH2, NH or O; provided that Q, V and W are not N at the same time; and in free base or acid addition salt form] were prepared as metabotropic glutamate receptors (mGluR) antagonist, especially mGluR5 antagonist,. For example, reaction of 6-chloro-N,N-diethylnicotinamide with 4-chloroaniline gave II in 56% yield. I were tested for inhibition of the glutamate induced elevation of intracellular Ca2+-concentration at a concentration of 10 μM, and I were also in clin. testing. Thus, I and their pharmaceutical compositions are useful as mGluR modulator for the treatment, prevention or delay of progression of cognitive dysfunction. The experimental process involved the reaction of Ethyl 5-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate(cas: 85614-89-7).Application of 85614-89-7

The Article related to pyridine derivative preparation metabotropic glutamate receptor modulator, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Application of 85614-89-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On June 28, 2007, Glatthar, Ralf; Orain, David; Spanka, Carsten published a patent.SDS of cas: 85614-89-7 The title of the patent was Preparation of nicotinic acid derivatives as modulators of mGluR5 metabotropic glutamate receptors. And the patent contained the following:

Title compounds [I; R1 = (substituted) alkyl, PhCH2; R2 = H, (substituted) alkyl, PhCH2; R1R2N = (substituted) heterocyclyl; R3, R4 = halo, OH, alkyl, alkoxy, amino, alkylamino, dialkylamino; Q, V, W = CH, CR4, N; X = CH, N; Y = CH, CR3, N; Z = CR6aR6b, NR5, O; R5 = H, OH; R6a, R6b = H, halo, OH, amino, alkyl, alkoxy, haloalkyl; provided that Q, V, W are not all N], were prepared Thus, 6-chloro-N,N-diethylnicotinamide (preparation given) and 4-chloroaniline were heated in aqueous HOAc in a sealed vial at 100° overnight to give after chromatog. 6-(4-chlorophenylamino)-N,N-diethylnicotinamide hydrochloride. The latter at 10 μM gave 95% inhibition of mGluR5 activity. The experimental process involved the reaction of Ethyl 5-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate(cas: 85614-89-7).SDS of cas: 85614-89-7

The Article related to nicotinic acid derivative preparation mglur5 metabotropic glutamate receptor modulator, gastrointestinal nervous system urinary tract disorder treatment, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.SDS of cas: 85614-89-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem