In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 85686-48-2, name is 6-(2,4-Dichlorophenoxy)pyridin-3-amine, the common compound, a new synthetic route is introduced below. category: pyridine-derivatives
EXAMPLE 15 N-[6-(2,4-Dichlorophenoxy)pyridin-3-yl]-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxamide Following the procedure of Example 1, using 2,3,4,5-tetrahydro-1H-benzazepine and 6-(2,4-dichlorophenoxy)pyridin-3-amine as the starting materials, the title compound was prepared as a colorless solid (88%): mp 154-155 C.; IR (KBr) 3377, 3070, 3024, 3000, 2943, 2928, 2899, 1642, 1604, 1593, 1530, 1485, 1467, 1276, 1263, 1232, 1215, 863, 844, 819, 750, 734 cm-1; 1H NMR (400 MHz, CDCl3) delta7.98 (dd, J=8.8, 2.7 Hz, 1H), 7.93 (d, J=2.7 Hz, 1H), 7.45 (d, J=2.4 Hz, 1H), 7.26-7.23 (m, 1H), 7.18-7.12 (m, 4H), 7.10 (d, J=8.6 Hz, 1H), 6.95 (d, J=8.8 Hz, 1H), 6.50 (s, 1H), 3.68-3.66 (m, 4H), 3.02-3.00 (m, 4H); 13C NMR (100 MHz, CDCl3) delta158.8, 154.9, 149.0, 140.1, 139.0, 133.7, 131.9, 130.5, 130.3, 130.0, 128.0, 126.8, 124.3, 111.1, 47.1, 37.5; MS (EI) m/z 428 (M+-H), 426 (M+-H); HRMS (FAB) calcd. for C22H19Cl2N3O2+H: 428.0932, found: 428.0916; Anal. Calcd. for C22H19Cl2N3O2: C, 61.69; H, 4.47; N, 9.81. Found: C, 61.73; H, 4.54; N, 9.75.
The synthetic route of 85686-48-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Fu, Jian-Min; US2003/149024; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem