Synthetic Route of 856965-66-7, Adding some certain compound to certain chemical reactions, such as: 856965-66-7, name is 4,5-Dichloropyridin-2(1H)-one,molecular formula is C5H3Cl2NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 856965-66-7.
To a suspension of 4,5-dichloropyridin-2-ol (300mg, 1.83 mmol), and silver carbonate (504 mg, 1.83 mmol) in CHC13 (4 mL) was addediodomethane (0.229 mL, 3.66 mmol). The reaction was stirred for 16 h at 55 C under N2atmosphere. Then the reaction mixture was filtered and the filtrate was concentrated in vacuo to give a residue, which was purified by prep-TLC (Si02, PE: EtOAc = 1: 1, v/v) toafford the title compound. ?H NMR (400MHz, CD3OD) oe = 8.21 (s, 1H), 7.00 (s, 1H), 3.90(s, 3H)
According to the analysis of related databases, 856965-66-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MERCK SHARP & DOHME CORP.; MILLER, Michael; CHOBANIAN, Harry, R.; HE, Shuwen; HAO, Jinsong; PIO, Barbara; GUO, Yan; XIAO, Dong; (213 pag.)WO2018/118670; (2018); A1;,
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