Category: 85838-94-4

Elaboration of a proprietary thymidylate kinase inhibitor motif towards anti-tuberculosis agents was written by Song, Lijun;Risseeuw, Martijn D. P.;Froeyen, Matheus;Karalic, Izet;Goeman, Jan;Cappoen, Davie;Van der Eycken, Johan;Cos, Paul;Munier-Lehmann, Helene;Van Calenbergh, Serge. And the article was included in Bioorganic & Medicinal Chemistry in 2016.Reference of 85838-94-4 This article mentions the following:

We report the design and synthesis of a series of non-nucleoside MtbTMPK inhibitors (1-14) based on the gram-pos. bacterial TMPK inhibitor hit compound 1. A practical synthesis was developed to access these analogs. Several compounds show promising MtbTMPK inhibitory potency and allow the establishment of a structure-activity relationship, which is helpful for further optimization. In the experiment, the researchers used many compounds, for example, tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4Reference of 85838-94-4).

tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ璺痬ol閳? in pyridine vs. 150 kJ璺痬ol閳? in benzene). Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Reference of 85838-94-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Iron-Catalyzed Tunable and Site-Selective Olefin Transposition was written by Yu, Xiaolong;Zhao, Haonan;Li, Ping;Koh, Ming Joo. And the article was included in Journal of the American Chemical Society in 2020.Related Products of 85838-94-4 This article mentions the following:

The catalytic isomerization of C-C double bonds is an indispensable chem. transformation used to deliver higher-value analogs and has important utility in the chem. industry. Notwithstanding the advances reported in this field, there is compelling demand for a general catalytic solution that enables precise control of the C=C bond migration position, in both cyclic and acyclic systems, to furnish disubstituted and trisubstituted alkenes. Here, we show that catalytic amounts of an appropriate earth-abundant iron-based complex, a base and a boryl compound, promote efficient and controllable alkene transposition. Mechanistic investigations reveal that these processes likely involve in situ formation of an iron-hydride species which promotes olefin isomerization through sequential olefin insertion/灏?hydride elimination. Through this strategy, regiodivergent access to different products from one substrate can be facilitated, isomeric olefin mixtures commonly found in petroleum-derived feedstock can be transformed to a single alkene product, and unsaturated moieties embedded within linear and heterocyclic biol. active entities can be obtained. In the experiment, the researchers used many compounds, for example, tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4Related Products of 85838-94-4).

tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ璺痬ol閳? in pyridine vs. 150 kJ璺痬ol閳? in benzene). Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Related Products of 85838-94-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

2-Aryl-4,5,6,7-tetrahydro-1,3-benzothiazol-7-ols as a class of antitumor agents selectively active in securin^-/- cells was written by Zhang, Nan;Ayral-Kaloustian, Semiramis;Niu, Chuansheng;Nguyen, Thai;Upeslacis, Erik;Mansour, Tarek S.;Ragunathan, Shoba;Rosfjord, Edward. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.HPLC of Formula: 85838-94-4 This article mentions the following:

A series of 2-(4-aminophenyl)-4,5,6,7-tetrahydro-1,3-benzothiazol-7-ols have been developed as antitumor agents that showed high selectivity against aneuploid cell lines (vs diploid cell lines). Structure-activity relationship studies showed that a hydroxymethyl group at the 2-position of the Ph ring increased potency and selectivity. A pyrrolidinyl group at the 4-position of the Ph ring was comparable to a dimethylamino group. The corresponding 5-aza analogs, 2-(4-aminophenyl)-4,5,6,7-tetrahydro[1,3]thiazolo[4,5-c]pyridin-7-ols, retained potency and high level of selectivity against aneuploid cell growth (vs diploid cells). These 5-aza compounds exhibited higher water solubility and higher metabolic stability than the corresponding carba analogs. Compound 19 (I) showed the highest potency against MCF-7 and MDA-MB-361 lines and was selected for further evaluation. In the experiment, the researchers used many compounds, for example, tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4HPLC of Formula: 85838-94-4).

tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. HPLC of Formula: 85838-94-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Copper-Catalyzed Cross-Coupling between Alkyl (Pseudo)halides and Bicyclopentyl Grignard Reagents was written by Andersen, Claire;Ferey, Vincent;Daumas, Marc;Bernardelli, Patrick;Guerinot, Amandine;Cossy, Janine. And the article was included in Organic Letters in 2020.Computed Properties of C10H17NO2 This article mentions the following:

The development of a copper-catalyzed cross-coupling between primary and secondary (pseudo)halides and bicyclopentyl Grignard reagents is reported. Highly strained bicyclopentanes can be cross-coupled with a large panel of primary alkyl mesylates and secondary alkyliodides. The catalytic system is simple and cheap, and the reaction is general and chemoselective. In the experiment, the researchers used many compounds, for example, tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4Computed Properties of C10H17NO2).

tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Computed Properties of C10H17NO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Design, synthesis, and biological activity of piperidinediamine derivatives as factor Xa inhibitor was written by Mochizuki, Akiyoshi;Nakamoto, Yumi;Naito, Hiroyuki;Uoto, Kouichi;Ohta, Toshiharu. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2008.Recommanded Product: 85838-94-4 This article mentions the following:

Cyclohexanediamine I [X = X¹ = CH₂] was identified as an orally bioavailable factor Xa inhibitor. Two racemic cis-piperidinediamine analogs I [X = NR, X¹ = CH₂; X = CH₂, X¹ = NR] were investigated. I [X = NR, X¹ = CH₂, R = CO₂CMe₃, H, Ac, SO₂Me, CO₂Et] showed higher fXa inhibitory activity, anticoagulant activity, and aqueous solubility than I [X = CH₂, X¹ = NR] having same substituent. I [X = NR, X¹ = CH₂] having sp2 nitrogen, especially amide and urea derivatives, showed potent anticoagulant activity. I [X = NR, X¹ = CH₂, R = OCH₂OMe, NMe₂] showed high oral activities in rats. In the experiment, the researchers used many compounds, for example, tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4Recommanded Product: 85838-94-4).

tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Recommanded Product: 85838-94-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pd-catalyzed cross-coupling reactions with carbonyls: application in a very efficient synthesis of 4-aryltetrahydropyridines was written by Barluenga, Jose;Tomas-Gamasa, Maria;Moriel, Patricia;Aznar, Fernando;Valdes, Carlos. And the article was included in Chemistry – A European Journal in 2008.Computed Properties of C10H17NO2 This article mentions the following:

Readily available 4-piperidones are directly employed in a very efficient Pd-catalyzed synthesis of 4-aryltetrahydropyridines, which are important scaffolds in medicinal chem. The actual coupling partner, a tosylhydrazone, is generated in situ from the piperidone and tosylhydrazine. The reaction can be applied to other ketones and aldehydes, providing polysubstituted olefins directly from carbonyls by a very simple and efficient procedure. In the experiment, the researchers used many compounds, for example, tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4Computed Properties of C10H17NO2).

tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Computed Properties of C10H17NO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A three-step synthesis of 4-(4-iodo-1H-pyrazol-1-yl)piperidine, a key intermediate in the synthesis of Crizotinib was written by Fussell, Steven J.;Luan, Amy;Peach, Philip;Scotney, Gemma. And the article was included in Tetrahedron Letters in 2012.Safety of tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate This article mentions the following:

4-(4-Iodo-1H-pyrazol-1-yl)piperidine is a key intermediate in the synthesis of Crizotinib. We report a robust three-step synthesis that has successfully delivered multi-kilogram quantities of the key intermediate. The process includes nucleophilic aromatic substitution of 4-chloropyridine with pyrazole, followed by hydrogenation of the pyridine moiety and subsequent iodination of the pyrazole which all required optimization to ensure successful scale-up. In the experiment, the researchers used many compounds, for example, tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4Safety of tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate).

tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Safety of tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Multimetallic Ni- and Pd-Catalyzed Cross-Electrophile Coupling To Form Highly Substituted 1,3-Dienes was written by Olivares, Astrid M.;Weix, Daniel J.. And the article was included in Journal of the American Chemical Society in 2018.Computed Properties of C10H17NO2 This article mentions the following:

The synthesis of highly substituted 1,3-dienes from the coupling of vinyl bromides with vinyl triflates is reported for the first time. The coupling is catalyzed by a combination of (5,5′-bis(trifluoromethyl)-2,2′-bipyridine)NiBr₂ and (1,3-bis(diphenylphosphino)propane)PdCl₂ in the presence of a zinc reductant. This method affords tetra- and penta-substituted 1,3-dienes that would otherwise be difficult to access and tolerates electron-rich and -poor substituents, heterocycles, an aryl bromide, and a pinacol boronate ester. Mechanistically, the reaction appears to proceed by an unusual zinc-mediated transfer of a vinyl group between the nickel and palladium centers. In the experiment, the researchers used many compounds, for example, tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4Computed Properties of C10H17NO2).

tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Computed Properties of C10H17NO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pd₂dba₃/P(t-Bu)₃H.BF₄/Cy₂NMe Catalyzed Heck Coupling in Synthesis of 3-Alkenyl-1H-Isochromen-1-Ones was written by Dasaradhan, Changalaraya;Nawaz Khan, Fazlur-Rahman. And the article was included in Polycyclic Aromatic Compounds in 2022.Application of 85838-94-4 This article mentions the following:

An efficient catalytic system comprising Pd₂dba₃/P(t-Bu)₃H.BF₄/Cy₂NMe -for the Heck coupling in the synthesis of 3-alkenyl isochromen-1-ones, I (R = H, 6,7-(OMe)₂; R¹ = Ph, benzyl, pyridin-2-yl), II (R² = OH, OMe, NH₂, butoxy) and III (R³ = 3,6-dihydro-2H-pyran-4-yl, 1-[(tert-butoxy)(oxo)methane]-1,2,5,6-tetrahydropyridin-3-yl) has been developed. Air stable alkyl phosphonium salt, [(t-Bu)₃Ph]BF₄ was found to be vital for the activation of 3- chloroisochromen-1-one and 3-chloro-6,7-dimethoxy-1H-isochromen-1-one, in regio-selective Heck coupling reactions. The technique has addnl. been reached out to typharin I, penicilisorin II and artemidin analogs III. In the experiment, the researchers used many compounds, for example, tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4Application of 85838-94-4).

tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Application of 85838-94-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pd₂dba₃/P(t-Bu)₃H.BF₄/Cy₂NMe Catalyzed Heck Coupling in Synthesis of 3-Alkenyl-1H-Isochromen-1-Ones was written by Dasaradhan, Changalaraya;Nawaz Khan, Fazlur-Rahman. And the article was included in Polycyclic Aromatic Compounds in 2022.Application of 85838-94-4 This article mentions the following:

An efficient catalytic system comprising Pd₂dba₃/P(t-Bu)₃H.BF₄/Cy₂NMe -for the Heck coupling in the synthesis of 3-alkenyl isochromen-1-ones, I (R = H, 6,7-(OMe)₂; R¹ = Ph, benzyl, pyridin-2-yl), II (R² = OH, OMe, NH₂, butoxy) and III (R³ = 3,6-dihydro-2H-pyran-4-yl, 1-[(tert-butoxy)(oxo)methane]-1,2,5,6-tetrahydropyridin-3-yl) has been developed. Air stable alkyl phosphonium salt, [(t-Bu)₃Ph]BF₄ was found to be vital for the activation of 3- chloroisochromen-1-one and 3-chloro-6,7-dimethoxy-1H-isochromen-1-one, in regio-selective Heck coupling reactions. The technique has addnl. been reached out to typharin I, penicilisorin II and artemidin analogs III. In the experiment, the researchers used many compounds, for example, tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4Application of 85838-94-4).

tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Application of 85838-94-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem