Category: 85838-94-4

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 85838-94-4, name is tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate, molecular formula is C10H17NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. HPLC of Formula: C10H17NO2

To a solution of tert-butyl5,6-dihydropyridine-1(2H)-carboxylate (0.3627 g, 1.979 mmol) in CH2Ch (5 ml) at ooc was5 added a solution of mCPBA (0.53 g, 3.07 mmol) in CH2Cb (5 ml). The resulting reactionmixture was allowed to warm to rt and stirred over the weekend. The reaction was partitionedbetween EtOAc and 5% Na2S20 3. After separation of layers, the organic layer was washed withsat. NaHC03. brine, dried over anhydrous MgS0 4, filtered and concentrated to give the titlecompound as colorless oil.

With the rapid development of chemical substances, we look forward to future research findings about 85838-94-4.

Reference:
Patent; MERCK SHARP & DOHME CORP.; CHOBANIAN, Harry; PIO, Barbara; GUO, Yan; DING, Fa-Xiang; DONG, Shuzhi; WALSH, Shawn, P.; JIANG, Jinlong; KIM, Dooseop; WO2015/95097; (2015); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 85838-94-4, name is tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate, the common compound, a new synthetic route is introduced below. Recommanded Product: 85838-94-4

To a solution of 0.50 g (2.73 mmol) of tert-butyl 3,6-dihydro-2H-pyridine-i-carboxylate in 30 mL of DCM was added 0.92 g (4.09 mmol) of mCPBA. The resultant solution was stirred at 20C for 18 h. TLCindicated that the reaction was complete. The reaction was diluted with DCM, washed with aq. NaHCO3, aq. Na2S2O3 and brine, dried over Na2SO4, filtered and concentrated. The residue was purified by column chromatography (PE/EA, 5/i, R1= 0.2) to give 0.43 g of tert-butyl 7-oxa-4-azabicyclo[4.i.0]heptane-4- carboxylate as a colorless oil.MS (+ESI): 144.1 [M+H].?H NMR (400 MHz, CDC13) ppm: 4.09-3.58 (m, 2H), 3.57-3.02 (m, 4H), 2.18-1.84 (m, 2H), 1.47 (s,9H).

The synthetic route of 85838-94-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BASILEA PHARMACEUTICA AG; POHLMANN, Jens; STIEGER, Martin; REINELT, Stefan; LANE, Heidi; (286 pag.)WO2016/128465; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 85838-94-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 85838-94-4, name is tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a 1 L flask, with a large stir bar, is added tert-butyl 5,6-dihydropyridine-1(2H)-carboxylate (24.15 g, 132 mmol) and DCM (440 mL). The vessel is cooled in an ice/water bath and 3-chloroperoxybenzoic acid (45.5 g, 264 mmol) is added in one portion. After stirring for 30 min at 0 C., the cooling bath was removed and the mixture was allowed to stir for 24 h. To the suspension was added aqueous sodium metabisulfite (10%, 200 mL), water (100 mL) and DCM (200 mL) and was then stirred vigorously for 10 min. The organic layer is separated, washed with aqueous 1 N NaOH (3×200 mL), brine (200 mL), dried over anhydrous Na2SO4, filtered and concentrated in vacuo to yield the title compound.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 85838-94-4, tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate.

Reference:
Patent; BAO, JIANMING; GAO, XIAOLEI; KNOWLES, SANDRA L.; LI, I, CHUNSING; LO, MICHAEL MAN-CHU; MAZZOLA, Jr., ROBERT D.; ONDEYKA, DEBRA L.; STAMFORD, ANDREW W.; ZHANG, FENGQI; (214 pag.)US2017/183342; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 85838-94-4, name is tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate, molecular formula is C10H17NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. SDS of cas: 85838-94-4

To a solution of N-Boc-1,2,3,6-tetrahydropyridine (3.63 g, 21.0 mmol) in 40 niL of dichloromethane was added 3-chloroperoxybenzoic acid (2.75 g, 15.0 mmol). The reaction was stirred at room temperature for 4 h, then washed 3x with saturated aqueous potassium carbonate and once with brine. The solution was dried over sodium sulfate, filtered, and concentrated in vacuo to provide crude fert-butyl 7-oxa-3-azabicyclo[4,1.0]heptane-3-carboxylate that gave a proton NMR spectra consistent with theory.

With the rapid development of chemical substances, we look forward to future research findings about 85838-94-4.

Reference:
Patent; MERCK SHARP & DOHME CORP.; KUDUK, Scott, D.; CHANG, Ronald, K.; GRESHOCK, Thomas, J.; WO2011/25851; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.85838-94-4, name is tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate, molecular formula is C10H17NO2, molecular weight is 183.25, as common compound, the synthetic route is as follows.Formula: C10H17NO2

1′-(1-t-butoxycarbonyl-3-hydroxypiperidin-4-yl)-3,4-dihydro-spiro[naphthalene1(2H),4′-piperidine] (19c) and 1′-(1-t-butoxycarbonyl-4-hydroxypiperidin-3-yl)-3,4-dihydro-spiro[naphthalene-1(2H),4′-piperidine] (20c) A mixture of the hydrochloride of 10 (4.9 g, 20.6 mmol) and 5.8 g (21 mmol) of the isomeric bromohydrins derived from 1-t-butoxycarbonyl-l,2,3,6-tetrahydropyridine (see Procedure above) in absolute ethanol (25 mL) and triethylamine (15 mL) was refluxed for 24 h. Since TLC (silica gel, Hexanes/Ethyl acetate: 50/50) failed to show any progress in the reaction, solid potassium carbonate (7.26 g, 52.5 mmol) was added and the mixture was refluxed for four more days. After cooling, the salts were filtered off and the volatiles were removed under reduced pressure. The remaining brown oil was dissolved in ethyl acetate (30 mL) and the organic layer was successively washed with water (2*20 mL) and brine (20 mL), dried (Na2 SO4) and concentrated. The mixture of 19c and 20c was obtained as an orange oil (6.7 g, 84%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,85838-94-4, tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate, and friends who are interested can also refer to it.

Reference:
Patent; Regents of the University of Minnesota; US5457207; (1995); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 85838-94-4 ,Some common heterocyclic compound, 85838-94-4, molecular formula is C10H17NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

tert-butyl 5,6-dihydropyridine-1(2H)-carboxylate (2) (1 mol)was added to a solution of potassium osmate (0.1 mol) and NMO(2 mol) in THF and H2O (4:1; 10 v). The reaction mixturewas stirredat RT for 16 h and a solution of saturated sodium metabisulfite (10v) was added to quench the excess oxidant. The reaction mixturewas diluted with water (40 v) and extracted with EtOAc (2 x 20 v).The combined organic layers were washed with saturated brinesolution, dried over Na2SO4 and evaporated under vacuo. Purificationwas done by flash column chromatography using EtOAc inhexane, afforded the desired product as a clear liquid in 88% yield.1H NMR (400 MHz, CDCl3): d 3.84 (br s, 1H), 3.75 (br s, 1H),3.56e3.50 (m, 2H), 3.41 (dd, J 13.2, 3.6 Hz, 1H), 3.28e3.22 (m, 1H),1.84e1.76 (m, 1H), 1.70e1.63 (m, 1H), 1.44 (s, 9H); 13C NMR(100 MHz, CDCl3): d 155.35, 79.96, 68.43, 67.91, 45.66, 40.17, 29.51,28.32; LC-MS (ESI) m/z Calcd. for C10H19NO4: 217.13, Found: 216.06[M H]-

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,85838-94-4, its application will become more common.

Reference:
Article; Kasturi, Siva Prasad; Surarapu, Sujatha; Uppalanchi, Srinivas; Dwivedi, Shubham; Yogeeswari, Perumal; Sigalapalli, Dilep Kumar; Bathini, Nagendra Babu; Ethiraj, Krishna S.; Anireddy, Jaya Shree; European Journal of Medicinal Chemistry; vol. 150; (2018); p. 39 – 52;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem