Category: 86129-63-7

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 86129-63-7, name is Ethyl 2,4-dichloro-6-methyl-3-pyridinecarboxylate, the common compound, a new synthetic route is introduced below. Formula: C9H9Cl2NO2

General procedure: To a solution of 2,4-dichloro-6-methylnicotinic acid ethyl ester (2.49 mmol) in 6 mL EtOH was added NaOEt (2.61 mmol). The reaction mixture was heated to 60C overnight in a closed vessel. At RT, the mixture was diluted with EtOAc and washed with aq. NH4CI solution. The organic layer was dried over MgS04 and concentrated in vacuo. Purification by (KP-SIL from Biotage) using Hept/EtOAc (1/1 ) gives the desired product as beige solid; LC-MS (C): tR = 0.83 min; [M+H]+: 244.13.

The synthetic route of 86129-63-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; HILPERT, Kurt; HUBLER, Francis; KIMMERLIN, Thierry; MURPHY, Mark; RENNEBERG, Dorte; STAMM, Simon; WO2013/14587; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 86129-63-7, Adding some certain compound to certain chemical reactions, such as: 86129-63-7, name is Ethyl 2,4-dichloro-6-methyl-3-pyridinecarboxylate,molecular formula is C9H9Cl2NO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 86129-63-7.

To a solution of 2- (IH-PYRAZOL-3-YL)-1, 3-THIAZOLE (7.71 g, 1.05 eq) in anh. DMF (61 mL), at 0C, under N2, was added NaH 60% in mineral oil (2.03 g, 1. 05 eq) and the reaction mixture was stirred for 10 min. at 0C and then for 1 hr at room temperature. Intermediate 1 (11.34 g, 48.0 MMOL) was then added as a solution in anh. DMF (35 mL) at 0C and the resulting solution was heated at 110C for 3 hr. The reaction was then quenched with water, extracted with EtOAc, washed with brine, dried over anh. NA2SO4, filtered and concentrated in vacuo. The crude product was purified by flash chromatography (silica gel, cHex/EtOAc 7: 3) to give 7.02 g of the title compound as a white solid. NMR (‘H, CDCl3) : 8 7.91 (d, 1H), 7.91 (d, 1H), 7.41 (d, 1H), 7.31 (s, 1H), 7.18 (d, 1H), 4.50 (q, 2H), 2.78 (s, 3H), 1.25 (t, 3H). MS (M/Z) : 349 [MH] +.

According to the analysis of related databases, 86129-63-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SB PHARMCO PUERTO RICO INC; NEUROCRINE BIOSCIENCES INC; GLAXO GROUP LIMITED; WO2004/62665; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 86129-63-7 ,Some common heterocyclic compound, 86129-63-7, molecular formula is C9H9Cl2NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Step 3. Preparation of 2-chloro-4-methoxy-6-methyl-nicotinic acid ethyl ester (B17-3): A solution of B17-2 (30 g, 128.2 mmol) in methanol (102 mL) was cooled to 0 C. and treated portion-wise over 30 minutes with NaOMe (8.5 g, 157.4 mmol). The reaction mixture was then heated at 60 C. for 5 hours. The reaction mixture was cooled to 25 C., filtered, and concentrated. The resultant residue was diluted with DCM (350 mL), filtered through a Celite bed, and washed with DCM. The combined filtrates were concentrated, and the resultant residue was purified by chromatography (silica gel; 6% EtOAc in petroleum ether as eluting solvent) to provide B17-3 as a pale yellow solid. Yield: 20.62 g, 70%. 1H NMR (CDCl3): delta 6.66 (s, 1H), 4.4 (q, 2H), 3.95 (s, 1H), 3.92 (s, 3H), 2.52 (s, 3H) and 1.38 (t, 3H). Mass: (M+1) 230 calculated C10H12ClNO3.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 86129-63-7, Ethyl 2,4-dichloro-6-methyl-3-pyridinecarboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Pfizer Inc.; US2009/54395; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem