Category: 861673-68-9

Related Products of 861673-68-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 861673-68-9, name is 2-(2-(tert-Butyl)phenoxy)pyridin-3-amine, molecular formula is C15H18N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A mixture of 2-(2-tert-Butylphenoxy)-3-aminopyridine (Intermediate 1) (50 mg, 0.20 mmol) and 2-methylbenzoyl isothiocyanate (36 muL, 0.24 mmol, 1.2 eq) in DCM (10 mL) was heated at reflux for 1 h. The mixture was cooled to rt and evaporated to give the crude product. Purification by flash chromatography (silica, 0-20% EtOAc/hexane gradient) provided Example 423a (91 mg) as white crystals. (M+H)+=420.25.

According to the analysis of related databases, 861673-68-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Sutton, James C.; Pi, Zulan; Ruel, Rejean; L’Heureux, Alexandre; Thibeault, Carl; Lam, Patrick Y. S.; US2006/173002; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 861673-68-9, name is 2-(2-(tert-Butyl)phenoxy)pyridin-3-amine. A new synthetic method of this compound is introduced below., name: 2-(2-(tert-Butyl)phenoxy)pyridin-3-amine

A solution of 2-(2-tert-butylphenoxy)pyridin-3-amine (342 mg, 1.41 mmol) in dry THF (5 mL) was cooled at 0 C. and treated successively with n-BuLi (1.6M, 0.89 mL, 1.42 mmol) and chloropyrazine (90 mg, 0.79 mmol). After stirring at 23 C. for 24 h, the reaction was diluted with AcOEt. The organic solution was washed with H2O, dried (MgSO4) and concentrated to give crude material. Purification by flash chromatography (silica, CH2Cl2) provided Example 216 (40 mg, 16%) as a yellow foam. (M+H)+=320; 1H NMR (400 MHz, CDCl3) delta ppm 1.43 (s, 9 H), 7.00 (dd, J=7.8, 1.3 Hz, 1 H), 7.04 (dd, J=8.1, 5.0 Hz, 1 H), 7.37 (dt, J=7.3, 1.3 Hz, 1 H), 7.25 (dd, J=7.9, 1.8 Hz, 1 H), 7.29 (bs, 1 H), 7.50 (dd, J=8.1, 1.8 Hz, 1H), 7.82 (dd, J=5.1, 1.8 Hz, 1 H), 8.11 (bs, 1 H), 8.24 (bs, 1 H), 8.84 (dd, J=8.1, 1.8 Hz, 1 H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 861673-68-9, 2-(2-(tert-Butyl)phenoxy)pyridin-3-amine.

Reference:
Patent; Sutton, James C.; Pi, Zulan; Ruel, Rejean; L’Heureux, Alexandre; Thibeault, Carl; Lam, Patrick Y. S.; US2006/173002; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 861673-68-9, 2-(2-(tert-Butyl)phenoxy)pyridin-3-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 2-(2-(tert-Butyl)phenoxy)pyridin-3-amine, blongs to pyridine-derivatives compound. Recommanded Product: 2-(2-(tert-Butyl)phenoxy)pyridin-3-amine

104a 1-(2-(2-tert-butylphenoxy)pyridin-3-yl)-3-(2, 4-dichlorophenyl) thiourea [00324] A solution of lb (40 mg, 0.17 mmol) and 2,5- dichlorophenylisothiocyanate (37 mg, 0.18 mmol) in dioxane (2 mL) was heated at 60C for 6 h. More 2,5-dichlorophenylisothiocyanate (37 mg, 0.18 mmol) was added and the mixture was heated at 60C for 8 days. The mixture was concentrated and the residue was purified by column chromatography on silica gel using a continuous gradient from 0% to 40% ethyl acetate in hexanes as eluant. Half of the material was carried to the next step without further purification, the other half was purified by preparative HPLC (continuous gradient from 40% B to 100%, B; A = 90: 10: 0.1 H20 : MeOH: TFA; B = 90 : 10: 0.1 MeOH: H2O : TFA) to afford 104a (8 mg, 43%). 1H NMR (400 MHz, CD30D) 8 ppm 1. 38 (m, 9 H), 6.93 (dd, J=7. 83,1. 52 Hz, 1 H), 7.15 (m, 3 H), 7. 31 (dd, J=8. 59, 2.27 Hz, 1 H), 7.44 (dd, J=7. 83,1. 77 Hz, 1 H), 7.52 (d, J=2. 53 Hz, 1 H), 7.68 (d, J=8. 59 Hz, 1 H), 7.90 (dd, J=5. 05,1. 77 Hz, 1 H), 8.35 (dd, J=7. 71,1. 89 Hz, 1 H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,861673-68-9, 2-(2-(tert-Butyl)phenoxy)pyridin-3-amine, and friends who are interested can also refer to it.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2005/70920; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem