Adding a certain compound to certain chemical reactions, such as: 864830-16-0, 5-Bromo-2-fluoro-4-methylpyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 864830-16-0, blongs to pyridine-derivatives compound. HPLC of Formula: C6H5BrFN
5-Bromo-2-methoxy-4-methylpyridine (B3.1) (0356) Sodium (4.8 g, 0.2 mol) was added to a stirred solution of 80 mL CH3OH portion by portion. After addition, 5-bromo-2-fluoro-4-methylpyridine (7.6 g, 40 mmol) was added subsequently by neat. Then the clear solution was stirred at rt overnight. The reaction was quenched by water (400 mL), extracted with dichloromethane (300 mL×3). The combined organic phase was washed with brine, dried over sodium sulphate, filtered and concentrated to give the title compound (6.95 g, 86%) as a pale yellow solid. 1H NMR (500 MHz, CDCl3) delta 2.31 (s, 3H), 3.87 (s, 3H), 6.61 (s, 1H), 8.15 (s, 1H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,864830-16-0, its application will become more common.
Reference:
Patent; Novartis AG; CHAN, Ho Man; GU, Xiang-Ju Justin; HUANG, Ying; LI, Ling; MI, Yuan; QI, Wei; SENDZIK, Martin; SUN, Yongfeng; WANG, Long; YU, Zhengtian; ZHANG, Hailong; ZHANG, Ji Yue (Jeff); ZHANG, Man; ZHANG, Qiong; ZHAO, Kehao; (134 pag.)US2016/176882; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem