Category: 865156-50-9

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 865156-50-9, name is (4-Bromopyridin-2-yl)methanamine. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 865156-50-9

Compound 39.2. N-((4-Bromopyridin-2-yl)methyl)formamide. To a 500-mL round-bottom flask, was placed (4-bromopyridin-2-yl)methanamine (compound 39.1, 8.0 g, crude) and formic acid (200 mL). The solution was stirred for 2 h at 100 C, then cooled and the pH was adjusted to 7 by careful and slow addition of aqueous sodium carbonate (sat.). The aqueous phase was extracted with ethyl acetate (3 x 200 mL) and the combined organic layers were washed with brine (3 x 30 mL), dried (Na2S04), filtered, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography with ethyl acetate as the eluent to yield the title compound as a yellow oil (8.0 g, 90% pure, 65% yield over 2 steps).

With the rapid development of chemical substances, we look forward to future research findings about 865156-50-9.

Reference:
Patent; 3-V BIOSCIENCES, INC.; OSLOB, Johan D.; MCDOWELL, Robert S.; JOHNSON, Russell; YANG, Hanbiao; EVANCHIK, Marc; ZAHARIA, Cristiana A.; CAI, Haiying; HU, Lily W.; WO2014/8197; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.865156-50-9, name is (4-Bromopyridin-2-yl)methanamine, molecular formula is C6H7BrN2, molecular weight is 187.04, as common compound, the synthetic route is as follows.Application In Synthesis of (4-Bromopyridin-2-yl)methanamine

Preparation 72 tert-butyl [(4-bromopyridin-2-yl)methyl]carbamate Di-tert-butyl dicarbonate (4 g, 18.28 mmol), triethylamine (3 mL, 21.93 mmol) and 4- dimethylaminopyridine (40 mg, 0.36 mmol) were added to a solution of 1-(4- bromopyridin-2-yl)methanamine (Preparation 73, 1.9 g, 10.1 mmol) in dichloromethane (40 mL) and the reaction mixture was stirred for 18 hours. The mixture was quenched with water (50 mL), extracted with dichloromethane (100 mL) and the organic layer was dried over magnesium sulfate and solvent was evaporated in vacuo. The residue was purified by silica gel column chromatography eluting with 1 : 1 ethyl acetate:heptane to give the title compound as a colourless oil (1.99 g, 95%). (0982) 1 H NMR (400MHz, CDCI3): delta ppm 1.46 (s, 9H), 4.42 (d, 2H), 5.45 (br s, 1 H), 7.34-7.36 (m, 1 H), 7.45 (s, 1 H), 8.34 (d, 1 H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,865156-50-9, (4-Bromopyridin-2-yl)methanamine, and friends who are interested can also refer to it.

Reference:
Patent; PFIZER INC.; SWAIN, Nigel Alan; BROWN, Alan Daniel; JONES, Lyn Howard; MARRON, Brian Edward; RAWSON, David James; RYCKMANS, Thomas; STORER, Robert Ian; WEST, Christopher William; WO2015/181797; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 865156-50-9, Adding some certain compound to certain chemical reactions, such as: 865156-50-9, name is (4-Bromopyridin-2-yl)methanamine,molecular formula is C6H7BrN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 865156-50-9.

d) N-(4-Bromopyridin-2-ylmethyl) formamide; 20. 00 g of C-(4-bromopyridin-2-yl)methylamine are taken up in 60 ml of formic acid and the solution is heated to reflux over 3 hours. The reaction solution is cooled to room temperature and concentrated by evaporation, and the residue is taken up in saturated aqueous sodium hydrogencarbonate solution {300 mu) and the aqueous solution is extracted with dichloromethane (3×300 mi). The combined organic phases are washed with water (300 mi), dried over sodium sulphate and concentrated by evaporation. The title compound is identified on the basis of the Rf value from the residue by means of flash chromatography (SiO2 60F)

According to the analysis of related databases, 865156-50-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SPEEDEL EXPERIMENTA AG; WO2005/90304; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem