Related Products of 865664-04-6, Adding some certain compound to certain chemical reactions, such as: 865664-04-6, name is 2-Chloro-3-cyclopropylpyridine,molecular formula is C8H8ClN, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 865664-04-6.
Palladium(ll) acetate (61 mg, 0.27 mmol) and di-fert-butyl[3,4,5,6-tetramethyl-2′,4′,6′-tri(propan-2-yl)biphenyl-2-yl]phosphane (130 mg, 0.27 mmol) were added to a mixture of C6 (615 mg, 4.00 mmol), C5 (1 .0 g, 2.6 mmol) and cesium carbonate (2.6 g, 8.0 mmol) in 1,4-dioxane (25 mL). The reaction mixture was stirred at 120 C under microwave irradiation for 5 hours, then diluted with ethyl acetate (50 mL) and filtered. After removal of solvents in vacuo, the residue was purified via silica gel chromatography (Gradient: 0% to 25% ethyl acetate in petroleum ether) to provide the product as a yellow gum. Yield: 900 mg, 1 .8 mmol, 69%. LCMS m/z 494.1 [M+H]+. 1 H NMR (400 MHz, CDCl3) delta 8.02 (dd, J=4.8, 1.8 Hz, 1 H), 7.30 (dd, J=7.4, 1.8 Hz, 1 H), 7.11 -7.14 (m, 1 H), 7.08-7.10 (m, 2H), 7.01 (dd, J=7.5, 4.8 Hz, 1 H), 5.51 (AB quartet, JAB=9.3 Hz, DeltanuAlphaBeta=3.8 Hz, 2H), 3.74-3.80 (m, 2H), 3.08 (s, 3H), 2.18 (s, 3H), 2.16-2.24 (m, 1 H), 1.70 (s, 3H), 1.00-1.06 (m, 4H), 0.74-0.79 (m, 2H), 0.03 (s, 9H).
According to the analysis of related databases, 865664-04-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; PFIZER INC.; BRODNEY, Michael Aaron; DAVOREN, Jennifer Elizabeth; DOUNAY, Amy Beth; EFREMOV, Ivan Viktorovich; GRAY, David Lawrence Firman; GREEN, Michael Eric; HENDERSON, Jaclyn Louise; LEE, Chewah; MENTE, Scot Richard; O’NEIL, Steven Victor; ROGERS, Bruce Nelsen; ZHANG, Lei; WO2014/207601; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem