Category: 86649-57-2

Reference of 86649-57-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 86649-57-2, name is 3-Pyridyloxyacetic acid, molecular formula is C7H7NO3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Add O-(7-azabenzotriazol- 1 -yl)-N,N,N?,N?-tetramethyluroniumhexafluorophosphate (584.56 mg, 1.81 mmol) and triethylamine (306.11 mg, 421.63 tL, 3.02 mmol) to a solution of 1-cyclopropyl-N-(1,2,3,4-tetrahydroisoquinolin-6-10 yl)methanesulfonamide (322.30 mg, 1.21 mmol) and 2-(3-pyridyloxy)acetic acid (185.30 mg, 1.21 mmol) in dimethylfomamide (6 mL). Stir the mixture at room temperature for 18 hours. Concentrate under reduced pressure. Pre-purify by an ion exchangechromatography, eluting with 10% methanol/dichloromethane followed by 2 N NH3 inmethanol. Concentrate the latter basic fraction and further purify the crude material by HPLC (XTeffa MS C18 21×100 m) eluting with a mobile phase of 20 mM ammonium carbonate at pH 9 in water/ACN (20% to 40% ACN over 8 minutes at 25 mL/minute) to afford the title compound (203 mg, 0.51 mmol). MS (m/z): 402 (M+1).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 86649-57-2, 3-Pyridyloxyacetic acid.

Reference:
Patent; ELI LILLY AND COMPANY; BURKHOLDER, Timothy Paul; DEL PRADO, Miriam Filadelfa; FERNANDEZ, Maria Carmen; HEINZ II, Lawrence Joseph; PRIETO, Lourdes; ZHAO, Genshi; WO2015/54060; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 86649-57-2, Adding some certain compound to certain chemical reactions, such as: 86649-57-2, name is 3-Pyridyloxyacetic acid,molecular formula is C7H7NO3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 86649-57-2.

Add slowly 1-propanephosphonic acid cyclic anhydride (122.30 g, 100.00 mL,192.18 mmol) to a solution of 2-hydroxy-2-methyl-N-( 1,2,3 ,4-tetrahydroisoquinolin-6-yl)propane-1-sulfonamide hydrochloride (46.90 g, 146.18 mmol), 2-(3-pyridyloxy)acetic acid (27.00 g, 176.31 mmol), dimethylformamide (708.98 g, 750.00 mL, 9.70 mol), triethylamine (59.53 g, 82.00 mL, 588.31 mmol) at 0 C. Allow the reaction to warm slowly to room temperature and stir overnight. Add saturated aqueous sodium sulfate solution (500 mL) and water (500 mL). Extract with dichloromethane (3 xl L), combine the organic layers, dry over anhydrous sodium sulfate, filter and concentrate underreduced pressure. Purify by silica gel chromatography eluting with a mobile phase of dichloromethane/methanol (0% to 10% methanol over 90 minutes). Combine fractions containing a mixture of peaks from previous purification and purify by silica gel chromatography eluting with a mobile phase of dichloromethane/methanol (0% to 10% methanol over 45 minutes) to afford the title compound (8.00 g, 19.05 mmol).Combine the two fractions to afford the title compound (38.00 g, 90.58 mmol). MS (m/z): 420 (M+1).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 86649-57-2, 3-Pyridyloxyacetic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ELI LILLY AND COMPANY; BURKHOLDER, Timothy Paul; DEL PRADO, Miriam Filadelfa; FERNANDEZ, Maria Carmen; HEINZ II, Lawrence Joseph; PRIETO, Lourdes; ZHAO, Genshi; WO2015/54060; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem