Related Products of 867012-70-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.867012-70-2, name is 6-Methoxy-5-methylpyridin-3-amine, molecular formula is C7H10N2O, molecular weight is 138.17, as common compound, the synthetic route is as follows.
6′-Methoxy-5′-methyl-2,3,5,6-tetrahydro-[1,3′]bipyridinyl-4-one A slurry of iodide salt 1-benzyl-1-methyl-4-oxo-piperidinium (Ref: Tortolani, R.; Org. Lett., Vol. 1, No 8, 1999) (3.61 g, 10.86 mmol) in water (10 mL) was added slowly to a refluxing solution of 2-methoxy-5-amino-3-picolin (1 g, 7.24 mmol) and potassium carbonate (0.140 g, 1.013 mmol) in ethanol (20 mL). The reaction mixture was heated to reflux for an additional 3 h. The reaction mixture was cooled to rt and partitioned between CH2Cl2 and water. The organic layer was separated and washed with an addition portion of CH2Cl2. The combined organic layers were washed with brine, dried over sodium sulfate, filtered and concentrated to give the crude product which was purified by flash-chromatography on silica gel (heptane/ethylacetate 1/1) to afford 6′-methoxy-5′-methyl-2,3,5,6-tetrahydro-[1,3′]bipyridinyl-4-one (1.15 g, yield 72%) as a light yellow gum. 1H-NMR (400 MHz, DMSO, 298K) delta ppm 2.12 (s, 3H) 2.42 (t, 4H) 3.46 (t, 4H) 3.80 (s, 3H) 7.40 (d, 1H) 7.71 (d, 1H). LCMS: [M+H]+=221.1, Rt(3)=1.41 min.
The chemical industry reduces the impact on the environment during synthesis 867012-70-2, I believe this compound will play a more active role in future production and life.
Reference:
Patent; NOVARTIS AG; COOKE, Nigel Graham; FERNANDES GOMES DOS SANTOS, Paulo Antonio; FURET, Pascal; HEBACH, Christina; HOGENAUER, Klemens; HOLLINGWORTH, Gregory; KALIS, Christoph; LEWIS, Ian; SMITH, Alexander Baxter; SOLDERMANN, Nicolas; STAUFFER, Frederic; STRANG, Ross; STOWASSER, Frank; TUFFILLI, Nicola; VON MATT, Anette; WOLF, Romain; ZECRI, Frederic; US2015/342951; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem