Category: 86718-01-6

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 86718-01-6, name is Methyl imidazo[1,2-a]pyridine-7-carboxylate. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of Methyl imidazo[1,2-a]pyridine-7-carboxylate

Hydrazine monohydrate (10 ml, 636 mmol) was added to methyl imidazo[1,2-a]pyridine-7-carboxylate (CAS: 86718-01-6) (11.2 g, 63.57 mmol) in solution in MeOH (300 ml). The reaction mixture was refluxed for 3 hours, then additional hydrazine monohydrate (10 ml, 636 mmol) was added and the mixture was refluxed overnight. After cooling to room temperature, the precipitate was filtered, washed with EtOH and dried yielding 13 g (quantitative) of intermediate shown.

With the rapid development of chemical substances, we look forward to future research findings about 86718-01-6.

Reference:
Patent; ASTEX THERAPEUTICS LIMITED; US2012/41000; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 86718-01-6, name is Methyl imidazo[1,2-a]pyridine-7-carboxylate. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 86718-01-6

Hydrazine monohydrate (10 ml, 636 mmol) was added to methyl imidazo[1,2-a]pyridine-7-carboxylate (CAS: 86718-01-6) (11.2 g, 63.57 mmol) in solution in MeOH (300 ml). The reaction mixture was refluxed for 3 hours, then additional hydrazine monohydrate (10 ml, 636 mmol) was added and the mixture was refluxed overnight. After cooling to room temperature, the precipitate was filtered, washed with EtOH and dried yielding 13 g (quantitative) of intermediate shown.

With the rapid development of chemical substances, we look forward to future research findings about 86718-01-6.

Reference:
Patent; ASTEX THERAPEUTICS LIMITED; US2012/41000; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 86718-01-6 ,Some common heterocyclic compound, 86718-01-6, molecular formula is C9H8N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Procedure A2 – Ester HydrolysisTo a solution of methyl imidazo[1 ,2-a]pyridine-7-carboxylate (3.Og, 17.04 mmol, 1.0 equiv) in EtOH (150 ml) was added 2M aqueous KOH (85 ml, 170 mmol, 10 equiv). The solution was heated for 30 min at 600C. After cooling to room temperature, the reaction was neutralized (HCI) and solvents were removed under reduced pressure. The residue was stirred in EtOH (2 x 100 ml) and filtered. The solvent was removed under reduced pressure and the resulting product was used in the next step without further purification. MS: [M+H]+ 163.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 86718-01-6, Methyl imidazo[1,2-a]pyridine-7-carboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ASTEX THERAPEUTICS LIMITED; WO2009/47522; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem