Reference of 870065-73-9, Adding some certain compound to certain chemical reactions, such as: 870065-73-9, name is 2,5,6-Trifluoronicotinonitrile,molecular formula is C6HF3N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 870065-73-9.
A solution of 1.04 M KOtBu in t-BuOH (110 mL, 114 mmol) pre-mixed with THF (20 mL) was added dropwise over 15 min to a stirred 0 C. solution of 2,5,6-trifluoro-nicotinonitrile (16.0 g, 101 mmol) contaminated with an additional 4.6 g DMSO, as prepared in the preceding step, in t-BuOH (80 mL) and THF (15 mL; to prevent freezing). The resulting homogeneous reddish-amber solution was stirred for an additional 5 min at 0 C., the ice bath was then removed, and the solution stirred for an addititional 20 min at rt. The reaction was then quenched with 5 M NH4Cl (100 mL) and extracted with ether (2×100 mL). The combined organic layers were washed with water (1×100 mL), 1 M NaCl (1×150 mL), and 4 M NaCl (1×100 mL), and the clear purple organic layer was dried (Na2SO4), concentrated under reduced pressure, taken up in ether (50 mL), and filtered through a pad of diatomaceous earth. The filter cake was washed with ether (3×50 mL), and the combined filtrates were concentrated under reduced pressure at 50-60 C. to afford 20.89 g of a clear purple oil. NMR indicated an 89:11 mol ratio of the title compound and 2,6-di-tert-butoxy-5-fluoro-nicotinonitrile (18.22 g title compound; 85%). 1H-NMR (300 MHz, CDCl3) delta 7.60 (dd, 1H), 1.67 (s, 9H)
According to the analysis of related databases, 870065-73-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Kreutter, Kevin; Lu, Tianbao; Lee, Yu Kai; Teleha, Christopher; Player, Mark; Zhu, Xizhen; US2006/241148; (2006); A1;,
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