Category: 87109-10-2

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 87109-10-2, name is 3-Phenylpyridin-2-amine, the common compound, a new synthetic route is introduced below. Formula: C11H10N2

General procedure: To a solution of a2-aminopyridine derivative 2 or 4 (0.9 mmol) in absolute EtOH(5 mL) was added dropwise ethyl 4,4,4-trifluorobutynoate 1 (230 mg, 1.4 mmol). The mixturewas stirred at room temperature for 30 minutes before an additional portion of 1 (150 mg, 0.9 mmol) was added. The reaction mixture was stirred at room temperature untilcompletion of the reaction. The solvent was then evaporated under reducedpressure and the residue was triturated with Et2O (20 mL) andfiltered off to afford the expected pyrido[1,2-a]pyrimidin-2-ones 3.

The synthetic route of 87109-10-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Silpa, Laurence; Niepceron, Alisson; Laurent, Fabrice; Brossier, Fabien; Penichon, Melanie; Enguehard-Gueiffier, Cecile; Abarbri, Mohamed; Silvestre, Anne; Petrignet, Julien; Bioorganic and Medicinal Chemistry Letters; vol. 26; 1; (2016); p. 114 – 120;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 87109-10-2, name is 3-Phenylpyridin-2-amine. A new synthetic method of this compound is introduced below., name: 3-Phenylpyridin-2-amine

To a solution of 3-phenylpyridin-2-amine (10.0 g, 55.8 mmol) and di-tert-butyl dicarbonate (48.7 g, 223 mmol) in DCM (200 mL) was added DMAP (13.6 g, 112 mmol) in batches. The resulting mixture was stined at 26 C for 16 h, then washed with brine (100 mL x 3), dried over Na2SO4and concentrated. The residue was purified by flash silica gel chromatography (ISCO; 120 g SepaFlash Silica Flash Column, EtOAc in petroleum ether: 0- 40%, 50 mL/min, dry loaded) to give the title compound.?H NMR (400 MHz, CDC13) oe 8.52 (d, J = 3.1 Hz, 1H), 7.75 (dd, J = 1.6, 7.4 Hz, 1H), 7.34-7.45 (m, 6H), 1.30 (s, 18H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 87109-10-2, 3-Phenylpyridin-2-amine.

Reference:
Patent; MERCK SHARP & DOHME CORP.; STUMP, Craig A.; CHEN, Yi Heng; LIU, Ping; MENG, Dongfang; WU, Jane; LI, Chun Sing; QI, Zhiqi; (163 pag.)WO2016/161572; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 87109-10-2, name is 3-Phenylpyridin-2-amine. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 3-Phenylpyridin-2-amine

To a solution of 3-phenylpyridin-2-amine (1.00 g, 5.88 mmol) in dichloromethane (30 mL) at 0 C was added a solution of o-mesitylsulfonyl hydroxylamine (2.81 g, 11.8 mmol) in dichloromethane (20 mL) dropwise. The resulting mixture was warmed to 20 C and stined for 2 h. The mixture was concentrated, and the residue was diluted with isopropyl ether (40 mL) and stined for 15 mm. The precipitate was filtered, washed with isopropyl ether (20 mL x 3), and dried to give the title compound. MS: m/z = 186.0 (M+ 1).

With the rapid development of chemical substances, we look forward to future research findings about 87109-10-2.

Reference:
Patent; MERCK SHARP & DOHME CORP.; STUMP, Craig A.; CHEN, Yi Heng; LIU, Ping; MENG, Dongfang; WU, Jane; LI, Chun Sing; QI, Zhiqi; (163 pag.)WO2016/161572; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem