Adding a certain compound to certain chemical reactions, such as: 871826-12-9, (5-(Trifluoromethyl)pyridin-2-yl)methanamine hydrochloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 871826-12-9, blongs to pyridine-derivatives compound. name: (5-(Trifluoromethyl)pyridin-2-yl)methanamine hydrochloride
General procedure: The carboxylic acid 8 is dissolved in DMF and 2 eq. of the corresponding amine component, 1.5 eq. of HATU and 3 eq. of triethylamine are added. The reaction mixture is stirred at rt until TLC and/or LCMS indicate complete consumption of the starting material (2 h), then water is added. The formed precipitate is filtered off, washed with water and dried in a vacuum drying cabinet at 40C. If appropriate, the product is purified by preparative HPLC.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,871826-12-9, its application will become more common.
Reference:
Patent; BAYER INTELLECTUAL PROPERTY GMBH; PANKNIN, Olaf; BAeURLE, Stefan; RING, Sven; SCHWEDE, Wolfgang; BONE, Wilhelm; NOWAK-REPPEL, Katrin; BENDER, Eckhard; NUBBEMEYER, Reinhard; GNOTH, Mark, Jean; WO2013/107743; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem