Category: 871836-51-0

Electric Literature of 871836-51-0 , The common heterocyclic compound, 871836-51-0, name is 4-Chloro-1H-pyrazolo[4,3-c]pyridine, molecular formula is C6H4ClN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

10152] A mixture of tert-butyl 4-chloro-1H-pyrazolo[4,3- c]pyridine (30.6 mg, 0.2 mmol) and E-001 (68 mg, 0.2 mmol) was heated at 1000 C. overnight. MeOH (2 mE) was added and the resultant was purified by Prep-TEC (ethyl acetate petroleum ether=11) to give D-01-02 (50 mg, 54.5percent) as a yellow oil.

The synthetic route of 871836-51-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; F. Hoffmann-La Roche AG; Savira pharmaceuticals GmbH; European Molecular Biology Laboratory; Schulz-Gasch, Tanja; Weikert, Robert; Neidhart, Werner; Buschmann, Helmut; Szolar, Oliver; Wolkerstorfer, Andrea; Handler, Norbert; Roch, Franz-Ferdinand; Cusack, Stephen; (69 pag.)US2016/2227; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 871836-51-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.871836-51-0, name is 4-Chloro-1H-pyrazolo[4,3-c]pyridine, molecular formula is C6H4ClN3, molecular weight is 153.5691, as common compound, the synthetic route is as follows.

To a solution of 4-chloro-IH-pyrazolo[4,3-clpyridine (100 mg, 0.6Smmoi) (3 mL) was added NaI-l (78 mg, 1.95 mmol, 60 wt% in oil) at 0C under N2. The mixture was stirred at 0C for 40 minutes. Mel (277 mg, 1,95 mmol) was added at 25C. The mixture wasstirred for another 2 hours. The mixture was quenched with saturated Ni-14C1 aqueous solution and extracted with ELOAc (20 mL x 3). The combined organic layer was dried over magnesium sulfate, filtered and concentrated in vacuo. The residue was purified by Prep-HPLC to give the title compound 56 (50.2 mg) as yellow oil, 57 (30 mg) as yellow oil. LRMS miz (M+H) 168.1, 170.1 found, 168.0, 170.1 required.

The chemical industry reduces the impact on the environment during synthesis 871836-51-0, I believe this compound will play a more active role in future production and life.

Reference:
Patent; MERCK SHARP & DOHME CORP.; LIVERTON, Nigel; KUDUK, Scott D.; BESHORE, Doug C.; MENG, Na; LUO, Yunfu; (127 pag.)WO2016/101119; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 871836-51-0, 4-Chloro-1H-pyrazolo[4,3-c]pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyridine-derivatives, blongs to pyridine-derivatives compound. category: pyridine-derivatives

Preparation P3 4-Chloro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[4,3-c]pyridine (P3) p-Toluenesulfonic acid monohydrate (2.4 g, 13 mmol) and 3,4-dihydro-2H-pyran (99percent, 45 mL, 520 mmol) were sequentially added to a suspension of 4-chloro-1H-pyrazolo[4,3-c]pyridine (20.0 g, 130 mmol) in dichloromethane (400 mL). The reaction mixture was allowed to stir at room temperature for 24 hours, at which time it was washed with saturated aqueous sodium bicarbonate solution. The organic layer was dried over sodium sulfate, filtered, and concentrated in vacuo. Purification via silica gel chromatography (Eluents: 10percent, then 30percent, then 50percent ethyl acetate in heptane) afforded the product as a white solid. Yield: 27.51 g, 115.7 mmol, 89percent. LCMS m/z 238.1 [M+H+]. 1H NMR (400 MHz, CDCl3) delta 8.19 (d, J=6.0 Hz, 1H), 8.16 (d, J=0.9 Hz, 1H), 7.47 (dd, J=6.0, 0.9 Hz, 1H), 5.73 (br dd, J=9.0, 2.7 Hz, 1H), 3.97-4.04 (m, 1H), 3.72-3.80 (m, 1H), 2.43-2.53 (m, 1H), 2.07-2.20 (m, 2H), 1.65-1.85 (m, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,871836-51-0, 4-Chloro-1H-pyrazolo[4,3-c]pyridine, and friends who are interested can also refer to it.

Reference:
Patent; PFIZER INC; DAVOREN, JENNIFER ELIZABETH; DOUNAY, AMY BETH; EFREMOV, IVAN VIKTOROVICH; GRAY, DAVID LAWRENCE FIRMAN; MENTE, SCOT RICHARD; O’NEIL, STEVEN VICTOR; ROGERS, BRUCE NELSEN; SUBRAMANYAM, CHAKRAPANI; ZHANG, LEI; US2014/128374; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 871836-51-0, name is 4-Chloro-1H-pyrazolo[4,3-c]pyridine. A new synthetic method of this compound is introduced below., category: pyridine-derivatives

Intermediate 153-Bromo-4-chloro-1H-pyrazolo[4,3-c]pyridineN-bromosuccinimide (1.87 g, 10.5 mmol) was added to a solution of Intermediate 11 (1.61 g, 10.5 mmol) in acetonitrile (50 ml), and the mixture was heated to reflux for 3 h. The solvents were evaporated and DCM (60 ml) was added to the crude solid and the mixture stirred at r.t. for 30 min. The beige solid was filtered off, washed with DCM, then dried under vacuum (1.98 g, 81percent). 1H NMR (400 MHz, DMSO-c/6) delta ppm 7.69 (d, J=6.0 Hz, 1 H), 8.22 (d, J=6.0 Hz, 1 H); m/z (ES+APCI)+: 232 / 234 / 236 [M + H]+.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 871836-51-0, 4-Chloro-1H-pyrazolo[4,3-c]pyridine.

Reference:
Patent; MEDICAL RESEARCH COUNCIL TECHNOLOGY; MCIVER, Edward, Giles; SMILJANIC, Ela; HARDING, Denise, Jamilla; HOUGH, Joanne; WO2010/106333; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 871836-51-0 ,Some common heterocyclic compound, 871836-51-0, molecular formula is C6H4ClN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Compound 1 (1.00 g, 6.5 mmol) was suspended in acetonitrile (100 ml), and sodium nitrite (339 mg, 8.5 mmol) was added thereto and reacted in an oil bath at 50 ° C. After 1 hour, the reaction mixture was cooled to room temperature, 2-deoxy-3,5-di-O- (p-toluyl) -alpha-D-ribofuranosyl chloride (2.66 g, 6.8 mmol) And the mixture was reacted at room temperature for 30 minutes. After filtration, the filtrate was concentrated under reduced pressure, the solvent was distilled off, the residue was adsorbed on a silica gel column, washed with a mixed solution of ethyl acetate and chloroform Eluting to give compound 2 (1.77 g, 54percent).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,871836-51-0, its application will become more common.

Reference:
Patent; NIHON UNIVERSITY; SAITOU, YOSHIO; SUZUKI, AZUSA; SAITOU, MIO; (41 pag.)JP2016/138078; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.871836-51-0, name is 4-Chloro-1H-pyrazolo[4,3-c]pyridine, molecular formula is C6H4ClN3, molecular weight is 153.5691, as common compound, the synthetic route is as follows.Formula: C6H4ClN3

To a solution of 4-chloro-1H-pyrazolo[4,3-c]pyridine (3.7 g) in THF (40 mL) was added NaH (1.93 g, 60% purity) at 0C. After stirring for 1 hour, benzyl bromide (3.15 mL) was added, and the mixture was stirred at 15C for 15 hours. The reaction mixture was quenched with water and extracted ethyl acetate. The organic layers were washed with brine, dried over Na2SO4, concentrated, and purified by silica gel chromatography (petroleum ether : ethyl acetate = 50 : 1 to 20 : 1) to give the target compound (3.1 g) as a solid. (2045) [00999] MS: (M+H+): 244.0

At the same time, in my other blogs, there are other synthetic methods of this type of compound,871836-51-0, 4-Chloro-1H-pyrazolo[4,3-c]pyridine, and friends who are interested can also refer to it.

Reference:
Patent; HLA, Timothy; JILISHITZ, Irina; MEINKE, Peter; STAMFORD, Andrew; FOLEY, Michael; SATO, Ayumu; WADA, Yasufimi; FUKASE, Yoshiyuki; KINA, Asato; TAKAHAGI, Hiroki; IGAWA, Hideyuki; POLVINO, William J.; (0 pag.)WO2019/173790; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem