Category: 872355-63-0

Electric Literature of 872355-63-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.872355-63-0, name is Methyl 1H-pyrrolo[3,2-b]pyridine-5-carboxylate, molecular formula is C9H8N2O2, molecular weight is 176.172, as common compound, the synthetic route is as follows.

Preparation of 2-methyl-2-(5-{[3-(5-{[(oxan-4-yl)amino]methyl}-1-(2,2,2-trifluoroethyl)-1H-pyrrolo[3,2-b]pyridin-2-yl)prop-2-yn-1-yl]amino}pyridin-2-yl)propanenitrile To a solution of methyl 1H-pyrrolo[3,2-b]pyridine-5-carboxylate (3.01 g, 17.05 mmol) in dimethylformamide (30 mL) at 0 C. was added sodium hydride (890 mg, 22.17 mmol, 60% in mineral oil). The mixture was stirred at 0 C. for 30 min, and PhSO2Cl (2.2 mL, 17.05 mmol) was added. The ice bath was then removed, and the mixture was allowed to warm up to room temperature and was stirred overnight at room temperature. The reaction mixture was poured into ice/water (300 mL) and stirred for 1 h. The solids were filtered, washed with water (100 mL) and hexane (50 mL), and the resulting solution was dried overnight to give methyl 1-(benzenesulfonyl)-1H-pyrrolo[3,2-b]pyridine-5-carboxylate as an off-white solid (3.50 g, 66% yield).

Statistics shows that 872355-63-0 is playing an increasingly important role. we look forward to future research findings about Methyl 1H-pyrrolo[3,2-b]pyridine-5-carboxylate.

Reference:
Patent; PMV Pharmaceuticals, Inc.; Vu, Binh; Dominique, Romyr; Li, Hongju; (222 pag.)US2017/240525; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 872355-63-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.872355-63-0, name is Methyl 1H-pyrrolo[3,2-b]pyridine-5-carboxylate, molecular formula is C9H8N2O2, molecular weight is 176.172, as common compound, the synthetic route is as follows.

A solution of methyl 1 H-pyrrolo[3,2-b]pyridine-5-carboxylate (Adesis Inc., New Castle, Delaware) (1.0 g, 5.68 mmol) and di-te/t-butyl dicarbonate (1.75 g, 7.95 mmol) in methanol (30 ml.) was passed through an H-cube hydrogenation apparatus equipped with a 10%Pd/C cartrige at 80 degrees Celsius and 80 bar 1.0 mL/minute. The effluent was then passed through the H-cube apparatus three additional times. The crude material was concentrated and the residue was purified by silica gel chromatography, eluting with a gradient mixture of 50% to 90% ethyl acetate to heptane to give 230 mg of methyl 2,3-dihydro-1 H-pyrrolo[3,2-b]pyridine-5-carboxylate and 300 mg of 1-te/t-butyl 5- methyl 2,3-dihydro-1 H-pyrrolo[3,2-b]pyridine-1 ,5-dicarboxylate.Methyl 2,3-dihydro-1 H-pyrrolo[3,2-b]pyridine-5-carboxylate:_1H NMR(deuterochloroform) delta 7.77 (d, J = 8.2 Hz, 1 H), 6.67 (d, J = 8.2 Hz, 1 H), 4.42 (br. s., 1 H), 3.88 (s, 3H), 3.69 (td, J = 8.6, 1.5 Hz, 2H), 3.17 (t, J = 8.7 Hz, 2H).1-te/t-Butyl 5-methyl 2,3-dihydro-1 H-pyrrolo[3,2-b]pyridine-1 ,5-dicarboxylate: 1H NMR (deuteurochloroform) delta 7.92 (d, J = 8.2 Hz, 2H), 4.00 (t, J = 8.9 Hz, 2H), 3.91 (s, 3H), 3.25 (t, J = 1.0 Hz, 2H), 1.52 (br. s., 9H).

The chemical industry reduces the impact on the environment during synthesis 872355-63-0, I believe this compound will play a more active role in future production and life.

Reference:
Patent; PFIZER INC.; DAROUT, Etzer; DENINNO, Michael, Paul; FUTATSUGI, Kentaro; GUIMARAES, Cristiano, Ruch, Werneck; LEFKER, Bruce, Allen; MASCITTI, Vincent; MCCLURE, Kim, Francis; MUNCHHOF, Michael, John; ROBINSON, Ralph, Pelton, Jr.; WO2010/128414; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 872355-63-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 872355-63-0, name is Methyl 1H-pyrrolo[3,2-b]pyridine-5-carboxylate. A new synthetic method of this compound is introduced below.

To the methanol (1OmL) and water (10 mL) suspension of lH-pyrrolo[3,2-b]pyridine- 5-carboxylic acid methyl ester (0.54 g) was added sodium hydroxide (0.37 g) . The reaction was heated at 70 0C for 2 h. The reaction mixture was concentrated and the residue obtained was redissolved in water. The aqueous solution was acidified with cone, hydrochloric acid to pH 2. The solid thus separated was filtered, washed with water and dried under high vacuum. It was used as such for the next step without any purification (Yield: 0.49 g, Rf: 0.213 min, Condition B, M+H+: 163). EPO

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,872355-63-0, its application will become more common.

Reference:
Patent; SCIOS, INC.; WO2006/112828; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem