Category: 87407-12-3

Application of 87407-12-3 , The common heterocyclic compound, 87407-12-3, name is 3-(Trifluoromethyl)picolinic acid, molecular formula is C7H4F3NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A mixture of 3-trifluoromethyl-2-pyridine carboxylic acid (0.33 g, 1.6 mmol), (dimethylamino)-N,N-dimethyl(3H-[l,2,3]triazolo[4,5-]pyridin-3-yloxy)methaniminium hexafluorophosphate (i.e. HATU, 0.059 g, 1.6 mmol), and N,N-diisopropylethylamine (0.33 g, 2.6 mmol) were stirred in 10 mL dichloromethane. After 15 min, 2-[5-[3- (trifluoromethyl)-lH-pyrazol-l-yl]-2-pyrazinyl]benzenamine (i.e. the compound obtained in Example 3, Step C above) (0.4 g, 1.3 mmol) was added and the reaction was stirred at ambient temperature for approximately 16 h. The reaction mixture was then diluted with water and extracted with ethyl acetate. The combined organic extracts were washed with water, dried over Na2S04, evaporated under reduced pressure and then purified using silica gel column chromatography (20% ethyl acetate in petroleum ether as eluent) to yield 0.36 g of the title compound, a compound of the present invention. in NMR (400 MHz, dmso-d6) delta 12.20 (s, 1H), 9.31 (s, 1H), 9.05 (m, 2H), 8.91 (bs, 1H), 8.36 (m, 2H), 7.97 (d, 1H), 7.85 (m, 1H), 7.61 (t, 1H), 7.41 (t, 1H), 7.18 (d, 1H).

The synthetic route of 87407-12-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; E. I. DU PONT DE NEMOURS AND COMPANY; BEREZNAK, James, Francis; TAGGI, Andrew, Edmund; KAR, Moumita; REDDY, Ravisekhara, P.; CAMPBELL, Mathew, James; WO2014/172190; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 87407-12-3, name is 3-(Trifluoromethyl)picolinic acid. This compound has unique chemical properties. The synthetic route is as follows. Safety of 3-(Trifluoromethyl)picolinic acid

Example 122; N- [3- ({2-[ (cyclopropylcarbonyl) amino] imidazo [1, 2-a] pyridin-6- yl}oxy) phenyl] -3- (trifluoromethyl) pyridine-2-carboxamide; To a solution of 3- (trifluoromethyl)pyridine-2-carboxylic acid (47.5 mg, 0.249 mmol) in tetrahydrofuran (5 mL) were addedN,N-dimethylformamide (2 drops) and oxalyl chloride (43.2 muL, 0.498 mmol), and the mixture was stirred at room temperature for 3 hr. The reaction mixture was concentrated under reduced pressure, the residue was dissolved in N,N-dimethylacetamide (6 mL) , and the solution was stirred at room temperature. N- [6- (3- Aminophenoxy) imidazo [1, 2-a]pyridin-2-yl] cyclopropanecarboxamide (66 mg, 0.214 mmol) was added thereto, and the mixture was stirred at room temperature for 3 days. The reaction mixture was diluted with aqueous sodium hydrogen carbonate solution and extracted with ethyl acetate. The organic layer was washed with aqueous sodium hydrogen carbonate solution and saturated brine, dried over anhydrous magnesium sulfate and filtrated. The filtrate was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (0%-?-100% ethyl acetate-hexane) to give the title compound (72.5 mg, 70%) as a white solid. 1H-NMR (DMSO-d6,400 MHz) delta 0.74 – 0.85 (4H, m) , 1.87 – 1.98 (IH, m) , 6.81 (IH, dd, J = 8.3, 2.4 Hz), 7.12 (IH, dd, J = 9.7, 2.3 Hz), 7.32 – 7.40 (2H, m) , 7.48 (IH, d, J = 9.5 Hz), 7.54 (IH, d, J = 8.1 Hz), 7.80 (IH, dd, J = 8.3, 4.9 Hz), 8.07 (IH, s) , 8.38 (IH, d, J = 7.8 Hz), 8.61 (IH, d, J = 2.2 Hz), 8.91 (IH, d, J = 4.4 Hz), 10.78 (IH, s) , 10.99 (IH, s) .

With the rapid development of chemical substances, we look forward to future research findings about 87407-12-3.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2008/150015; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem