Category: 874959-68-9

Application of 874959-68-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.874959-68-9, name is 5-Bromopyridine-2-sulfonyl chloride, molecular formula is C5H3BrClNO2S, molecular weight is 256.51, as common compound, the synthetic route is as follows.

Into a Vial was added the 5-Bromo-pyridine-2-sulfonic acid thiazol-2-ylamide (150 mg, 0.00047 mol), 9,9-DIMETHYL-4,5-BIS(DIPHENYLPHOSPHINO)XANTHENE (32 mg, 0.000056 mol), Tris(dibenzylideneacetone)dipalladium(0) (17 mg, 0.000019 mol), ART-CHEM-BB B001304 (120 mg, 0.00056 mol) and N,N-Dimethylacetamide (6.0 mL, 0.064 mol). The mixture was sparged with argon for 5 min. Sodium tert-butoxide (140 mg, 0.0014 mol) was added and the reaction mixture was heated at 120 C. for 30 min in microwave. The reaction mixture was filtered through celite. The filtrate was diluted with Ethyl acetate and washed with 0.1 N HCl solution, water (3×) and brine, dried over sodium sulfate, filtered and was concentrated to give the crude product that was purified on ISCO (0% to 100% Ethyl acetate in CHCl3). 125 mg of the product was obtained as a light tan solid.

The chemical industry reduces the impact on the environment during synthesis 874959-68-9, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Icagen; US2009/23740; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 874959-68-9, 5-Bromopyridine-2-sulfonyl chloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 874959-68-9, blongs to pyridine-derivatives compound. SDS of cas: 874959-68-9

5-Bromo-N-(4-methoxy-6-methyl-pyrimidin-2-yl)pyridine-2-sulfonamide (Intermediate Z) (0442) [00301] To a solution of 5-bromopyridine-2-sulfonyl chloride (1.00 g, 3.90 mmol, Intermediate W) in pyridine (10 mL) was added 4-methoxy-6-methyl-pyrimidin-2-amine (542 mg, 3.90 mmol). The reaction mixture was stirred at 15 C for 16 hrs. On completion, the reaction mixture was concentrated in vacuo and the residue was triturated with dichloromethane:methanol = 5:1 to give the title compound which was used directly without further purification. LCMS: (ES+) m/z (M+H)+ = 360.8, tR= 0.965.1H NMR (400MHz, DMSO- d6) delta = 12.96 (br. s., 1H), 8.75 (d, J = 1.6 Hz, 1H), 8.26 (dd, J = 1.8, 8.3 Hz, 1H), 7.99 (d, J = 8.3 Hz, 1H), 6.15 (s, 1H), 3.43 (s, 3H), 2.23 (s, 3H).

The synthetic route of 874959-68-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; RAZE THERAPEUTICS, INC.; MAINOLFI, Nello; MOYER, Mikel P.; SAIAH, Eddine; (264 pag.)WO2017/156181; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 874959-68-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 874959-68-9, name is 5-Bromopyridine-2-sulfonyl chloride. A new synthetic method of this compound is introduced below.

Ethyl 5-amino-3-methylbenzofuran-2-carboxylate (0.23 g, 1.05 mmol), 5-bromopyridine-2-sulfonyl chloride (0.54 g, 2.10 mmol), potassium carbonate(0.29 g, 2.10 mmol) was added successively to 30 mL of dichloromethane, and the mixture was stirred overnight at room temperature, and potassium carbonate was filtered off, and the residue was purified by column chromatography to yield 0.43 g (yield: 93.3%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,874959-68-9, 5-Bromopyridine-2-sulfonyl chloride, and friends who are interested can also refer to it.

Reference:
Patent; Jiangsu Hengrui Pharmaceutical Co., Ltd.; You Qidong; Wei Jinlian; Jiang Zhengyu; Guo Xiaoke; Xu Xiaoli; Zhang Xiaojin; (44 pag.)CN107619384; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 874959-68-9 , The common heterocyclic compound, 874959-68-9, name is 5-Bromopyridine-2-sulfonyl chloride, molecular formula is C5H3BrClNO2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 58(a) l-(5-Bromo-pyridine-2-sulfonyl)-4-methyl-piperazine; 5-Bromopyridine-2-sulfonyl chloride (as described in Example 52(b) (55.0 mg, 0.214 mmol) was dissolved in CH2Cl2 (1 mL) and 1-methyl-piperazine (26 muL, 0.236 mmol) was added. Stirring was continued at room temperature for 3 hours and saturated aqueous NaHCO3 (1 mL) was added. The mixture was diluted with CH2Cl2 (5 mL) and the aqueous phase was extracted with CH2Cl2 (3 x 5 mL). The combined organic phases were dried (Na2SO4) and concentrated to afford the title compound (61 mg, 89%). 1H NMR (400 MHz, CDCl3) delta ppm 2.29 (s, 3 H) 2.33 – 2.38 (m, 2 H) 2.45 – 2.50 (m, 2 H) 3.10 – 3.18 (m, 2 H) 3.30 – 3.37 (m, 2 H) 7.31 (d, J=4.29 Hz, 1 H) 7.81 (d, J=7.58 Hz, 1 H) 8.04 (dd, J=8.34, 2.27 Hz, 1 H); MS (ESI) m/z 321 (M + 1).

The synthetic route of 874959-68-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; WO2008/2244; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 874959-68-9, Adding some certain compound to certain chemical reactions, such as: 874959-68-9, name is 5-Bromopyridine-2-sulfonyl chloride,molecular formula is C5H3BrClNO2S, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 874959-68-9.

General procedure: To a pyridine (1.5 mL) solution of 5-((1S,2R)-1-amino-2-(6-fluoro-2,3-dimethylphenyl)propyl)-1,3,4-oxadiazol-2(3H)-one monohydrochloride (45 mg) obtained from Reference Example F1, 5-chloro-8-(chlorosulfonyl)-4-methyl-d3-chroman-4-ylacetate (80 mg) obtained in Reference Example E1 was added, and the reaction solution was stirred atroom temperature for 12 hours. The reaction solution was concentrated under reduced pressure, and the obtainedresidue was purified by silica gel column chromatography (eluent: hexane / ethyl acetate) to obtain the title compound(59 mg) as a 1: 1 diastereomer mixture.

According to the analysis of related databases, 874959-68-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Taiho Pharmaceutical Co., Ltd.; MIYAHARA, Seiji; UENO, Hiroyuki; HARA, Shoki; OGINO, Yoshio; (203 pag.)EP3466934; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 874959-68-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 874959-68-9, name is 5-Bromopyridine-2-sulfonyl chloride. This compound has unique chemical properties. The synthetic route is as follows.

A mA mixture of 5-bromo-2-pyridinesulfonyl chloride (0.30Og, 1.17mmol), pyrrolidine (0.0976ml, 1.17mmol) and TEA (0.326ml, 2.34mmol) in anhydrous DCM (6ml) was stirred at room temperature under nitrogen overnight. The reaction mixture was partitioned between DCM (20ml) and water (20ml), the layers separated and the DCM extract evaporated in vacuo to give the title compound as a pale brown solid (0.367g).MH+ = 293, rt = 2.74 min

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 874959-68-9, 5-Bromopyridine-2-sulfonyl chloride.

Reference:
Patent; GLAXO GROUP LIMITED; WO2008/145688; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 874959-68-9, Adding some certain compound to certain chemical reactions, such as: 874959-68-9, name is 5-Bromopyridine-2-sulfonyl chloride,molecular formula is C5H3BrClNO2S, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 874959-68-9.

[(2,2-Dimethyl-1 ,3-dioxolan-4-yl)methyl]amine (0.76ml, 5.85mmol), 5-bromo-2- pyridinesulfonyl chloride (1g, 3.9mmol), DIPEA (1.3ml, 7.8mmol), were stirred together in DCM (20ml) at room temperature under N2 for 1 h. The reaction mixture was extracted with sodium bicarbonate (20ml) dried on a phase separator and reduced under vacuum to give the title compound as a yellow solid ( 0.629g) MH+ 351/353, rt = 2.58 min

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 874959-68-9, 5-Bromopyridine-2-sulfonyl chloride, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GLAXO GROUP LIMITED; WO2008/145688; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem